World's Best Scientists 2026 revealed!
Xosé R. Bustelo

Xosé R. Bustelo

D-Index & Metrics

Molecular Biology

D-Index
68
Citations
16469
World Ranking
1515
National Ranking
18

Overview

Xosé R. Bustelo is affiliated with the University of Salamanca in Spain and has a research portfolio spanning over a hundred publications. Their work mainly intersects the fields of biochemistry, genetics, molecular biology, and medicine, with significant contributions to subfields such as molecular biology, oncology, cell biology, genetics, and immunology.

The scientist's research covers multiple topics including cancer-related molecular pathways, protein kinase regulation and GTPase signaling, chronic lymphocytic leukemia research, ubiquitin and proteasome pathways, RNA research and splicing, Hippo pathway signaling and YAP/TAZ, and RNA modifications in cancer.

Frequent publication venues for Bustelo include:

  • Cancers
  • Cells
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Oncogene

Among recent papers are the following notable publications:

  • "Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia" (2022, Molecular Cancer)
  • "Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis" (2021, The EMBO Journal)
  • "HERC Ubiquitin Ligases in Cancer" (2020, Cancers)
  • "VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma" (2020, Nature Communications)
  • "A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors" (2022, Cell Reports)

The scientist has collaborated frequently with other researchers, including:

  • L. Francisco Lorenzo-Martín
  • Balbino Alarcón
  • Isabel Fernández-Pisonero
  • Mercedes Dosil
  • Myriam Cuadrado

Xosé R. Bustelo's research contributions include extensive exploration of molecular signaling mechanisms and pathways critical to cancer biology and cellular proliferation. Their work on GTPase signaling and ubiquitin ligases contributes to understanding cellular regulation and oncogenic processes.

Best Publications

  • Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

    Z Songyang;S E Shoelson;J McGlade;P Olivier

  • S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells

    Wolf Dietrich Hardt;Li Mei Chen;Kornel E. Schuebel;Xosé R. Bustelo

  • Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

    Piero Crespo;Piero Crespo;Kornel E. Schuebel;Amy A. Ostrom;J. Silvio Gutkind

  • GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

    Xosé R. Bustelo;Vincent Sauzeau;Inmaculada M. Berenjeno

  • Regulatory and Signaling Properties of the Vav Family

    Xosé R. Bustelo

  • Analysis of receptor signaling pathways by mass spectrometry: Identification of Vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors

    Akhilesh Pandey;Alexandre V. Podtelejnikov;Blagoy Blagoev;Xosé R. Bustelo

  • Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

    Xosé R. Bustelo;Jeffrey A. Ledbetter;Mariano Barbacid

  • Phosphorylation‐dependent and constitutive activation of Rho proteins by wild‐type and oncogenic Vav‐2

    Kornel E. Schuebel;Nieves Movilla;José Luis Rosa;Xosé R. Bustelo

  • Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins

    Nieves Movilla;Xosé R. Bustelo

  • Vav proteins, adaptors and cell signaling.

    Xosé R Bustelo

  • Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins

    Daniela Poppe;Imke Tiede;Gerhard Fritz;Christoph Becker

  • Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

    Crespo P;Bustelo Xr;Aaronson Ds;Coso Oa

  • Tyrosine Phosphorylation Mediates Both Activation and Downmodulation of the Biological Activity of Vav

    Miguel López-Lago;Hyunmi Lee;Cristina Cruz;Nieves Movilla

  • The 90S Preribosome Is a Multimodular Structure That Is Assembled through a Hierarchical Mechanism

    Jorge Pérez-Fernández;Ángel C. Román;Javier De Las Rivas;Xosé R. Bustelo

  • The Vav–Rac1 Pathway in Cytotoxic Lymphocytes Regulates the Generation of Cell-mediated Killing

    Daniel D. Billadeau;Kathryn M. Brumbaugh;Christopher J. Dick;Renee A. Schoon

  • Rac1 function is required for Src-induced transformation: Evidence of a role for Tiam1 and Vav2 in Rac activation by Src

    Joan Marc Servitja;Maria Julia Marinissen;Akrit Sodhi;Xosé R. Bustelo

  • T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.

    Nuria Martínez-Martín;Elena Fernández-Arenas;Saso Cemerski;Pilar Delgado

  • Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.

    Kornel E. Schuebel;Xose R. Bustelo;Xose R. Bustelo;David A. Nielsen;Byoung Joon Song

  • Rac1 mediates STAT3 activation by autocrine IL-6

    Tatjana R. Faruqi;Dolores Gomez;Xosé R. Bustelo;Dafna Bar-Sagi

  • Human Proteinpedia enables sharing of human protein data.

    Suresh Mathivanan;Suresh Mathivanan;Mukhtar Ahmed;Natalie G Ahn;Hainard Alexandre

Frequent Co-Authors

Mariano Barbacid
Mariano Barbacid Spanish National Cancer Research Centre
Piero Crespo
Piero Crespo Spanish National Research Council
Balbino Alarcón
Balbino Alarcón Spanish National Research Council
Eugenio Santos
Eugenio Santos University of Salamanca
Pedro M. Fernandez-Salguero
Pedro M. Fernandez-Salguero University of Extremadura
J. Silvio Gutkind
J. Silvio Gutkind University of California, San Diego
Miguel Vicente-Manzanares
Miguel Vicente-Manzanares University of Salamanca
Oscar Llorca
Oscar Llorca Spanish National Research Council
Francisco Sánchez-Madrid
Francisco Sánchez-Madrid Autonomous University of Madrid
Jose A. Cancelas
Jose A. Cancelas Cincinnati Children's Hospital Medical Center

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Molecular Biology opens doors to a range of interdisciplinary and innovative career options. As online learning becomes more popular, students are exploring fields that complement biology, such as graphic design for science communication or library science for managing scientific archives. For those interested in blending creativity with technical expertise, explore the best online graphic design degree programs to help present scientific data visually.

Budget-conscious learners can look into cheap online interdisciplinary studies degree options, which allow for a custom mix of biology, communication, and technology courses. History enthusiasts may find the online history master's degree programs valuable, especially for those aiming to contextualize molecular discoveries in historical perspectives.

If organizing and sharing scientific knowledge appeals to you, it’s worth checking out what schools offer library science degrees — a growing field for graduates skilled in research and information management. Exploring these online degrees can expand your career pathways beyond traditional lab roles, opening opportunities in education, communication, museums, and beyond.

Best Scientists Citing Xosé R. Bustelo

Trending Scientists

Recently Published Articles