Cell biology, VAV1, GTPase, Tyrosine phosphorylation and Signal transduction are his primary areas of study. His research related to GTP-binding protein regulators and Syk might be considered part of Cell biology. His VAV1 research is multidisciplinary, incorporating elements of Molecular biology, Proto-Oncogene Proteins c-vav, RHOA and Mitogen-activated protein kinase.
His GTPase research is multidisciplinary, incorporating perspectives in RhoG, GTP', Small GTPase and Rac GTP-Binding Proteins. His work carried out in the field of Tyrosine phosphorylation brings together such families of science as Tyrosine kinase and Receptor tyrosine kinase. Xosé R. Bustelo works mostly in the field of Phosphorylation, limiting it down to concerns involving VAV2 and, occasionally, Cell signaling.
Xosé R. Bustelo spends much of his time researching Cell biology, GTPase, Signal transduction, Cancer research and VAV1. His studies in Cell biology integrate themes in fields like Proto-Oncogene Proteins c-vav and Cytoskeleton. His study in GTPase is interdisciplinary in nature, drawing from both Molecular biology, RhoG, GTP', RHOA and Rac GTP-Binding Proteins.
As a member of one scientific family, Xosé R. Bustelo mostly works in the field of Molecular biology, focusing on Gene expression and, on occasion, Complementary DNA. His Signal transduction research includes themes of Autocrine signalling and Effector. His Cancer research study incorporates themes from Carcinogenesis, Gene, Oncogene and Lymphoma.
His primary scientific interests are in Cell biology, Cancer research, Carcinogenesis, MAPK/ERK pathway and GTPase. His Cell biology research includes elements of VAV1, Ribosome biogenesis and Activator. His VAV1 research entails a greater understanding of T cell.
Xosé R. Bustelo combines subjects such as Pathogenesis, VAV2, Metastasis, Regulation of gene expression and PI3K/AKT/mTOR pathway with his study of Cancer research. His MAPK/ERK pathway research incorporates themes from Computational biology and Protein–protein interaction. His GTPase study frequently draws connections to other fields, such as Cancer cell.
His main research concerns Cell biology, MAPK/ERK pathway, Computational biology, Protein–protein interaction and Kinase. The various areas that he examines in his Cell biology study include Antigen, Affinity maturation and CD40. Xosé R. Bustelo conducts interdisciplinary study in the fields of MAPK/ERK pathway and Anti-Tumor Drugs through his works.
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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
Z Songyang;S E Shoelson;J McGlade;P Olivier.
Molecular and Cellular Biology (1994)
S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells
Wolf-Dietrich Hardt;Li-Mei Chen;Kornel E Schuebel;Xosé R Bustelo.
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
Piero Crespo;Piero Crespo;Kornel E. Schuebel;Amy A. Ostrom;J. Silvio Gutkind.
GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
Xosé R. Bustelo;Vincent Sauzeau;Inmaculada M. Berenjeno.
Regulatory and Signaling Properties of the Vav Family
Xosé R. Bustelo.
Molecular and Cellular Biology (2000)
Analysis of receptor signaling pathways by mass spectrometry: Identification of Vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors
Akhilesh Pandey;Alexandre V. Podtelejnikov;Blagoy Blagoev;Xosé R. Bustelo.
Proceedings of the National Academy of Sciences of the United States of America (2000)
Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates
Xosé R. Bustelo;Jeffrey A. Ledbetter;Mariano Barbacid.
Phosphorylation‐dependent and constitutive activation of Rho proteins by wild‐type and oncogenic Vav‐2
Kornel E. Schuebel;Nieves Movilla;José Luis Rosa;Xosé R. Bustelo.
The EMBO Journal (1998)
Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins
Nieves Movilla;Xosé R. Bustelo.
Molecular and Cellular Biology (1999)
Vav proteins, adaptors and cell signaling.
Xosé R Bustelo.
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