World's Best Scientists 2026 revealed!
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Molecular Biology
USA
2026

D-Index & Metrics

Molecular Biology

D-Index
147
Citations
100973
World Ranking
90
National Ranking
58

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Channing J. Der is a researcher affiliated with the University of North Carolina at Chapel Hill in the United States. Their work primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a strong emphasis on Molecular Biology, Oncology, and Cell Biology. The scientist's research explores several key topics including Protein Kinase Regulation and GTPase Signaling, Melanoma and MAPK Pathways, Pancreatic and Hepatic Oncology Research, as well as signaling pathways such as PI3K/AKT/mTOR in cancer.

The publication record of this researcher includes contributions to significant venues such as UNC Libraries, Cancer Research, and several specialized journals including bioRxiv (Cold Spring Harbor Laboratory), Molecular Cancer Research, and Science Signaling. The array of journals reflects a consistent focus on cancer biology and molecular signaling mechanisms.

Frequent co-authors collaborating with Channing J. Der include Adrienne D. Cox, Clint A. Stalnecker, Kirsten L. Bryant, Andrew M. Waters, and Kristina Drizyte-Miller, indicating a collaborative network within the cancer research community and related molecular biology fields.

Recent notable publications highlight ongoing research in cancer biology, with selected papers such as:

  • Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy, 2024, Nature
  • Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer, 2024, Nature
  • Combination Therapies with CDK4/6 Inhibitors to Treat KRAS- Mutant Pancreatic Cancer, 2022, Cancer Research
  • Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer, 2020, Cancer Cell
  • Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers, 2020, Cell Reports

Their research portfolio notably intersects the study of oncogenic signaling pathways and targeted cancer therapies. The scientist's work includes exploration of mechanisms regulating RAS proteins, which are pivotal in many forms of cancer. This focus is reflected in the recurring themes of RAS inhibition, signaling cascades, and combination treatment strategies targeting molecular pathways in cancer cells.

Award recognition includes being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2019, underscoring acknowledgment from the wider scientific community.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.

    P J Roberts;C J Der

  • Drugging the undruggable Ras: mission possible?

    Adrienne D. Cox;Stephen W. Fesik;Alec C. Kimmelman;Ji Luo

  • GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

    Kent L. Rossman;Channing J. Der;John Sondek

  • Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

    Kaikobad Irani;Yong Xia;Jay L. Zweier;Steven J. Sollott

  • The Ras superfamily at a glance.

    Krister Wennerberg;Kent Louis Rossman;Channing J Der

  • Increasing complexity of Ras signaling

    Sharon L Campbell;Sharon L Campbell;Roya Khosravi-Far;Kent L Rossman;Geoffrey J Clark

  • p21ras is modified by a farnesyl isoprenoid.

    Patrick J. Casey;Patricia A. Solski;Channing J. der;Janice E. Buss

  • Understanding Ras: ‘it ain’t over ’til it’s over’

    Janiel M. Shields;Kevin Pruitt;Aidan McFall;Amy Shaub

  • Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

    Patricia J. Keely;John K. Westwick;Ian P. Whitehead;Channing J. Der

  • Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses

    Channing J. der;Theodore G. Krontiris;Geoffrey M. Cooper

  • BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

    Ann Marie Pendergast;Lawrence A. Quilliam;Larry D. Cripe;Craig H. Bassing

  • Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

    Dominico Vigil;Jacqueline Cherfils;Kent L. Rossman;Channing J. Der

  • Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation.

    Roya Khosravi-Far;Patricia A. Solski;Geoffrey J. Clark;Michael S. Kinch

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • RAS isoforms and mutations in cancer at a glance

    G. Aaron Hobbs;Channing J. Der;Kent L. Rossman

  • Ras history: The saga continues.

    Adrienne D. Cox;Channing J. Der

  • Rho-family GTPases: it's not only Rac and Rho (and I like it).

    Krister Wennerberg;Channing J. Der

  • INCREASING COMPLEXITY OF THE RAS SIGNALING PATHWAY

    Anne B. Vojtek;Channing J. Der

Frequent Co-Authors

Adrienne D. Cox
Adrienne D. Cox University of North Carolina at Chapel Hill
Sharon L. Campbell
Sharon L. Campbell University of North Carolina at Chapel Hill
Roya Khosravi-Far
Roya Khosravi-Far Beth Israel Deaconess Medical Center
John Westwick
John Westwick Novartis (Switzerland)
John Sondek
John Sondek University of North Carolina at Chapel Hill
Lee M. Graves
Lee M. Graves University of North Carolina at Chapel Hill
Alec C. Kimmelman
Alec C. Kimmelman New York University
William E. Balch
William E. Balch Scripps Health
Brian K. Kay
Brian K. Kay University of Illinois at Chicago
Keith Burridge
Keith Burridge University of North Carolina at Chapel Hill

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