World's Best Scientists 2026 revealed!
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Best Female Scientists
2025
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Biology and Biochemistry
USA
2023

D-Index & Metrics

Best Female Scientists

D-Index
144
Citations
79791
World Ranking
192
National Ranking
120

Biology and Biochemistry

D-Index
147
Citations
84738
World Ranking
203
National Ranking
139

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2020 - Fellow of American Physical Society (APS) Citation For extraordinary advancements in the understanding of the structure and function of biomacromolecules, an algorithm for predicting RNA secondary structure, and the Conformational Selection and Population Shift concept as an alternative to the InducedFit model in molecular recognition
  • 2013 - Fellow of the International Society for Computational Biology

Overview

Ruth Nussinov is affiliated with the National Institutes of Health in the United States. Their research spans the field of biochemistry, genetics, and molecular biology, with a primary focus on molecular biology. Additional subfields of study include computational theory and mathematics, cell biology, oncology, and cancer research.

The scientist's work covers key topics such as protein kinase regulation and GTPase signaling, computational drug discovery methods, bioinformatics and genomic networks, protein structure and dynamics, melanoma and MAPK pathways, PI3K/AKT/mTOR signaling in cancer, and cancer genomics and diagnostics.

Frequent co-authors that have collaborated with Ruth Nussinov include Hyunbum Jang, Mingzhen Zhang, Yonglan Liu, Feixiong Cheng, and Chung-Jung Tsai.

Major publication venues for Ruth Nussinov's research include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Molecular Biology
  • Cancer Research
  • Current Opinion in Structural Biology
  • The Journal of Physical Chemistry B

Recent papers authored or co-authored by Ruth Nussinov are:

  • Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis (2021, Chemical Reviews)
  • Artificial intelligence in COVID-19 drug repurposing (2020, The Lancet Digital Health)
  • Target identification among known drugs by deep learning from heterogeneous networks (2020, Chemical Science)
  • Anticancer drug resistance: An update and perspective (2021, Drug Resistance Updates)
  • Deep generative molecular design reshapes drug discovery (2022, Cell Reports Medicine)

Ruth Nussinov has been recognized with awards such as the Fellow of the American Physical Society (APS) in 2020, for contributions including the understanding of biomacromolecule structure and function, RNA secondary structure prediction algorithms, and molecular recognition models. In 2013, the scientist was named Fellow of the International Society for Computational Biology.

Best Publications

  • PatchDock and SymmDock: servers for rigid and symmetric docking

    Dina Schneidman-Duhovny;Yuval Inbar;Ruth Nussinov;Haim J. Wolfson

  • The role of dynamic conformational ensembles in biomolecular recognition

    David D Boehr;Ruth Nussinov;Ruth Nussinov;Peter E Wright

  • Principles of docking: An overview of search algorithms and a guide to scoring functions

    Inbal Halperin;Buyong Ma;Haim Wolfson;Ruth Nussinov;Ruth Nussinov

  • Is allostery an intrinsic property of all dynamic proteins

    K. Gunasekaran;Buyong Ma;Ruth Nussinov;Ruth Nussinov

  • Factors enhancing protein thermostability

    Sandeep Kumar;Chung-Jung Tsai;Ruth Nussinov

  • Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review

    Peter Csermely;Tamás Korcsmáros;Tamás Korcsmáros;Huba J.M. Kiss;Gábor London

  • Induced fit, conformational selection and independent dynamic segments: an extended view of binding events

    Peter Csermely;Robin Palotai;Ruth Nussinov;Ruth Nussinov

  • Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

    Yiling Xiao;Buyong Ma;Dan McElheny;Sudhakar Parthasarathy

  • Efficient Unbound Docking of Rigid Molecules

    Dina Duhovny;Ruth Nussinov;Haim J. Wolfson

  • Algorithms for Loop Matchings

    Ruth Nussinov;George Pieczenik;Jerrold R. Griggs;Daniel J. Kleitman

  • Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?

    Ozlem Keskin;Attila Gursoy;Buyong Ma;Ruth Nussinov

  • Fast algorithm for predicting the secondary structure of single-stranded RNA

    Ruth Nussinov;Ann B. Jacobson

  • FOLDING FUNNELS, BINDING FUNNELS, AND PROTEIN FUNCTION

    Chung-Jung Tsai;Sandeep Kumar;Buyong Ma;Ruth Nussinov;Ruth Nussinov

  • FireDock: a web server for fast interaction refinement in molecular docking

    Efrat Mashiach;Dina Schneidman-Duhovny;Nelly Andrusier;Ruth Nussinov

  • FireDock: fast interaction refinement in molecular docking.

    Nelly Andrusier;Ruth Nussinov;Ruth Nussinov;Haim J. Wolfson

  • Protein–protein interactions: Structurally conserved residues distinguish between binding sites and exposed protein surfaces

    Buyong Ma;Tal Elkayam;Haim Wolfson;Ruth Nussinov

  • Folding funnels and binding mechanisms.

    Buyong Ma;Sandeep Kumar;Chung-Jung Tsai;Ruth Nussinov

  • Folding and binding cascades: dynamic landscapes and population shifts.

    Sandeep Kumar;Buyong Ma;Chung-Jung Tsai;Neeti Sinha

  • Allostery in Disease and in Drug Discovery

    Ruth Nussinov;Ruth Nussinov;Chung-Jung Tsai

  • Shape complementarity at protein–protein interfaces

    Raquel Norel;Shuo L. Lin;Haim J. Wolfson;Ruth Nussinov

Frequent Co-Authors

Buyong Ma
Buyong Ma Shanghai Jiao Tong University
Haim J. Wolfson
Haim J. Wolfson Tel Aviv University
Chung-Jung Tsai
Chung-Jung Tsai Leidos (United States)
Hyunbum Jang
Hyunbum Jang Leidos (United States)
Ozlem Keskin
Ozlem Keskin Koç University
Attila Gursoy
Attila Gursoy Koç University
Carlos Alemán
Carlos Alemán Universitat Politècnica de Catalunya
Feixiong Cheng
Feixiong Cheng Case Western Reserve University
Jie Zheng
Jie Zheng University of Akron
Guanghong Wei
Guanghong Wei Fudan University

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