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Ozlem Keskin

Ozlem Keskin

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Biology and Biochemistry
Turkey
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
14540
World Ranking
13650
National Ranking
10

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Turkey Leader Award
  • 2022 - Research.com Biology and Biochemistry in Turkey Leader Award
  • The Science Academy Society of Turkey - Bilim Akademisi Computational Biology
  • The Science Academy Society of Turkey - Bilim Akademisi Computational Biology
  • The Science Academy Society of Turkey - Bilim Akademisi Computational Biology

Overview

Ozlem Keskin is affiliated with Koç University in Turkey and has a research focus that spans several interconnected fields within biochemistry, genetics, molecular biology, and medicine. Their work contributes to understanding structural and computational aspects of biological systems, especially related to protein dynamics and interactions.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these, they have concentrated on subfields such as:

  • Molecular Biology
  • Computational Theory and Mathematics
  • Materials Chemistry
  • Neurology
  • Cell Biology

The primary topics addressed in Keskin's research encompass:

  • Protein Structure and Dynamics
  • Bioinformatics and Genomic Networks
  • Computational Drug Discovery Methods
  • Machine Learning in Bioinformatics
  • Protein Kinase Regulation and GTPase Signaling
  • Reproductive tract infections research
  • Endoplasmic Reticulum Stress and Disease

They have contributed extensively to scientific literature with notable recent papers including:

  • Androgen receptor-binding sites are highly mutated in prostate cancer, 2020, published in Nature Communications
  • Neuropsychiatric Symptoms of COVID-19 Explained by SARS-CoV-2 Proteins' Mimicry of Human Protein Interactions, 2021, Frontiers in Human Neuroscience
  • Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA, 2020, PLoS ONE
  • HMI-PRED: A Web Server for Structural Prediction of Host-Microbe Interactions Based on Interface Mimicry, 2020, Journal of Molecular Biology
  • Artificial intelligence based methods for hot spot prediction, 2021, Current Opinion in Structural Biology

The frequent coauthors working with Keskin include:

  • Attila Gürsoy
  • Simge Senyuz
  • Ruth Nussinov
  • Hyunbum Jang
  • Melisa Ece Zeylan

Keskin's work has appeared often in respected research venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Molecular Biology
  • Current Opinion in Structural Biology
  • The Journal of Physical Chemistry B
  • Biophysical Journal

Recognition for their contributions includes receiving an award from The Science Academy Society of Turkey - Bilim Akademisi for Computational Biology.

Best Publications

  • Anisotropy of Fluctuation Dynamics of Proteins with an Elastic Network Model

    A.R. Atilgan;S.R. Durell;R.L. Jernigan;M.C. Demirel

  • Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?

    Ozlem Keskin;Attila Gursoy;Buyong Ma;Ruth Nussinov

  • Hot Regions in Protein-Protein Interactions: The Organization and Contribution of Structurally Conserved Hot Spot Residues

    Ozlem Keskin;Buyong Ma;Ruth Nussinov;Ruth Nussinov

  • Predicting Protein-Protein Interactions from the Molecular to the Proteome Level

    Ozlem Keskin;Nurcan Tuncbag;Attila Gursoy

  • Identification of computational hot spots in protein interfaces

    Nurcan Tuncbag;Attila Gursoy;Ozlem Keskin

  • Transient protein-protein interactions

    Saliha Ece Acuner Ozbabacan;Hatice Billur Engin;Attila Gursoy;Ozlem Keskin

  • Ras Conformational Ensembles, Allostery, and Signaling.

    Shaoyong Lu;Shaoyong Lu;Hyunbum Jang;Serena Muratcioglu;Attila Gursoy

  • Predicting protein-protein interactions on a proteome scale by matching evolutionary and structural similarities at interfaces using PRISM

    Nurcan Tuncbag;Attila Gursoy;Ruth Nussinov;Ruth Nussinov;Ozlem Keskin

  • Human Cancer Protein-Protein Interaction Network: A Structural Perspective

    Gozde Kar;Attila Gursoy;Ozlem Keskin

  • A new, structurally nonredundant, diverse data set of protein–protein interfaces and its implications

    Ozlem Keskin;Ozlem Keskin;Chung-Jung Tsai;Haim Wolfson;Ruth Nussinov;Ruth Nussinov

  • PRISM: protein interactions by structural matching.

    Utkan Ogmen;Ozlem Keskin;A. Selim Aytuna;Ruth Nussinov

  • Protein-protein interactions: hot spots and structurally conserved residues often locate in complemented pockets that pre-organized in the unbound states: implications for docking.

    Xiang Li;Ozlem Keskin;Ozlem Keskin;Buyong Ma;Ruth Nussinov;Ruth Nussinov

  • Prediction of protein–protein interactions by combining structure and sequence conservation in protein interfaces

    A. Selim Aytuna;Attila Gursoy;Ozlem Keskin

  • HotPoint: hot spot prediction server for protein interfaces

    Nurcan Tuncbag;Ozlem Keskin;Attila Gursoy

  • GTP-Dependent K-Ras Dimerization

    Serena Muratcioglu;Tanmay S. Chavan;Benjamin C. Freed;Hyunbum Jang

  • Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma

    Hulya Ercan;Esra Birben;Evrim A. Dizdar;Ozlem Keskin

  • PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes

    Alper Baspinar;Engin Cukuroglu;Ruth Nussinov;Ozlem Keskin

  • Allostery and population shift in drug discovery

    Gozde Kar;Ozlem Keskin;Attila Gursoy;Ruth Nussinov;Ruth Nussinov

  • A survey of available tools and web servers for analysis of protein–protein interactions and interfaces

    Nurcan Tuncbag;Gozde Kar;Ozlem Keskin;Attila Gursoy

  • Proteins with Similar Architecture Exhibit Similar Large-Scale Dynamic Behavior

    O. Keskin;R.L. Jernigan;I. Bahar;I. Bahar

Frequent Co-Authors

Attila Gursoy
Attila Gursoy Koç University
Ruth Nussinov
Ruth Nussinov National Institutes of Health
Hyunbum Jang
Hyunbum Jang Leidos (United States)
Ivet Bahar
Ivet Bahar University of Pittsburgh
Buyong Ma
Buyong Ma Shanghai Jiao Tong University
Chung-Jung Tsai
Chung-Jung Tsai Leidos (United States)
Burak Erman
Burak Erman Koç University
Robert L. Jernigan
Robert L. Jernigan Iowa State University
Omer Kalayci
Omer Kalayci Hacettepe University
Akinori Sarai
Akinori Sarai Kyushu Institute of Technology

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