Chung-Jung Tsai spends much of his time researching Protein structure, Crystallography, Protein folding, Allosteric regulation and Folding. His work in the fields of Conformational ensembles overlaps with other areas such as Surface protein. His research in Crystallography focuses on subjects like Plasma protein binding, which are connected to Binding site.
His work deals with themes such as Polypeptide chain, Protein protein and Biological system, which intersect with Protein folding. His Allosteric regulation research includes themes of Protein function, Conformational change, Computational biology and Bioinformatics. His biological study spans a wide range of topics, including Evolutionary biology, Conformational isomerism, Mutation and Genetics.
Chung-Jung Tsai mostly deals with Protein folding, Crystallography, Protein structure, Allosteric regulation and Computational biology. His work is dedicated to discovering how Protein folding, Folding are connected with Conformational ensembles and other disciplines. His study on Crystallography also encompasses disciplines like
He combines subjects such as Chemical physics, Protein function and Peptide sequence with his study of Protein structure. His research integrates issues of Stereochemistry, Neuroscience, Drug discovery and Cell biology in his study of Allosteric regulation. His Computational biology research is multidisciplinary, relying on both Genetics, Protein–protein interaction, Plasma protein binding, Bioinformatics and Structural similarity.
His primary scientific interests are in Computational biology, Allosteric regulation, Cell biology, Signal transduction and Drug discovery. His work carried out in the field of Computational biology brings together such families of science as Host protein, Precision medicine, Cancer, Protein–protein interaction and Gene isoform. His Host protein study incorporates themes from Plasma protein binding and Molecular mimicry.
Chung-Jung Tsai has researched Allosteric regulation in several fields, including Protein kinase B, Phosphorylation, MAPK/ERK pathway, Function and PI3K/AKT/mTOR pathway. In his study, which falls under the umbrella issue of Cell biology, Cytoplasm and KRAS is strongly linked to Membrane. In his work, Small GTPase, Protein structure and Genotype is strongly intertwined with Phenotype, which is a subfield of Drug discovery.
His scientific interests lie mostly in Cell biology, Phenotype, Computational biology, Precision medicine and Allosteric regulation. His work on Intracellular, Kinase and CDC42 as part of general Cell biology study is frequently connected to Functional role, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. His research in Phenotype intersects with topics in Conformational ensembles, Proteomics, Classical pharmacology, Drug discovery and Personalized medicine.
His Computational biology research is multidisciplinary, incorporating perspectives in Cancer treatment, Cancer, Exome sequencing and Data sequences. His multidisciplinary approach integrates Precision medicine and Statistical analysis in his work. His Allosteric regulation research incorporates elements of Extracellular, Signal transduction, Protein kinase domain and Epidermal growth factor receptor.
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Factors enhancing protein thermostability
Sandeep Kumar;Chung-Jung Tsai;Ruth Nussinov.
Protein Engineering (2000)
FOLDING FUNNELS, BINDING FUNNELS, AND PROTEIN FUNCTION
Chung-Jung Tsai;Sandeep Kumar;Buyong Ma;Ruth Nussinov;Ruth Nussinov.
Protein Science (1999)
Folding and binding cascades: dynamic landscapes and population shifts.
Sandeep Kumar;Buyong Ma;Chung-Jung Tsai;Neeti Sinha.
Protein Science (2008)
Folding funnels and binding mechanisms.
Buyong Ma;Sandeep Kumar;Chung-Jung Tsai;Ruth Nussinov.
Protein Engineering (1999)
Allostery in Disease and in Drug Discovery
Ruth Nussinov;Ruth Nussinov;Chung-Jung Tsai.
Hydrogen bonds and salt bridges across protein-protein interfaces.
Dong Xu;Chung-Jung Tsai;Ruth Nussinov.
Protein Engineering (1997)
Studies of protein‐protein interfaces: A statistical analysis of the hydrophobic effect
Chung-Jung Tsai;Shuo Liang Lin;Haim J. Wolfson;Ruth Nussinov;Ruth Nussinov.
Protein Science (1997)
Allostery: absence of a change in shape does not imply that allostery is not at play.
Chung-Jung Tsai;Antonio del Sol;Ruth Nussinov;Ruth Nussinov.
Journal of Molecular Biology (2008)
The origin of allosteric functional modulation: multiple pre-existing pathways.
Antonio del Sol;Chung-Jung Tsai;Buyong Ma;Ruth Nussinov;Ruth Nussinov.
Extended disordered proteins: targeting function with less scaffold
Kannan Gunasekaran;Chung-Jung Tsai;Sandeep Kumar;David Zanuy.
Trends in Biochemical Sciences (2003)
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