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D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
20603
World Ranking
6236
National Ranking
2933

Overview

Chung-Jung Tsai is affiliated with Leidos in the United States and has contributed extensively to the field of biochemistry, genetics, and molecular biology, with a focus on molecular biology, cancer research, and genetics. Their research spans several subfields including cell biology and pulmonary and respiratory medicine.

The main areas of study in Tsai's work cover a broad spectrum of modern biological research topics. These include bioinformatics and genomic networks, cancer genomics and diagnostics, protein degradation and inhibitors, protein kinase regulation and GTPase signaling, genetics and neurodevelopmental disorders, genomics and chromatin dynamics, and the application of machine learning in bioinformatics.

Tsai has published research in a variety of scientific venues, frequently appearing in the Journal of Molecular Biology, Current Opinion in Structural Biology, Cancer Research, Bioinformatics, and bioRxiv hosted by Cold Spring Harbor Laboratory.

  • Journal of Molecular Biology
  • Current Opinion in Structural Biology
  • Cancer Research
  • Bioinformatics
  • bioRxiv (Cold Spring Harbor Laboratory)

Among the recent notable publications by Tsai are:

  • Anticancer drug resistance: An update and perspective (2021, Drug Resistance Updates)
  • Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs (2022, Journal of Molecular Biology)
  • How can same-gene mutations promote both cancer and developmental disorders? (2022, Science Advances)
  • Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK (2023, Biophysical Reviews)
  • Ras assemblies and signaling at the membrane (2020, Current Opinion in Structural Biology)

Tsai has collaborated frequently with several co-authors, including Ruth Nussinov, Hyunbum Jang, Mingzhen Zhang, Bengi Ruken Yavuz, and Nurcan Tunçbağ. These collaborations have produced multiple publications, indicating active partnerships in molecular biology and cancer-related research.

  • Ruth Nussinov
  • Hyunbum Jang
  • Mingzhen Zhang
  • Bengi Ruken Yavuz
  • Nurcan Tunçbağ

Best Publications

  • Factors enhancing protein thermostability

    Sandeep Kumar;Chung-Jung Tsai;Ruth Nussinov

  • FOLDING FUNNELS, BINDING FUNNELS, AND PROTEIN FUNCTION

    Chung-Jung Tsai;Sandeep Kumar;Buyong Ma;Ruth Nussinov;Ruth Nussinov

  • Folding funnels and binding mechanisms.

    Buyong Ma;Sandeep Kumar;Chung-Jung Tsai;Ruth Nussinov

  • Folding and binding cascades: dynamic landscapes and population shifts.

    Sandeep Kumar;Buyong Ma;Chung-Jung Tsai;Neeti Sinha

  • Allostery in Disease and in Drug Discovery

    Ruth Nussinov;Ruth Nussinov;Chung-Jung Tsai

  • Studies of protein‐protein interfaces: A statistical analysis of the hydrophobic effect

    Chung-Jung Tsai;Shuo Liang Lin;Haim J. Wolfson;Ruth Nussinov;Ruth Nussinov

  • Hydrogen bonds and salt bridges across protein-protein interfaces.

    Dong Xu;Chung Jung Tsai;Ruth Nussinov

  • Allostery: absence of a change in shape does not imply that allostery is not at play.

    Chung-Jung Tsai;Antonio del Sol;Ruth Nussinov;Ruth Nussinov

  • The origin of allosteric functional modulation: multiple pre-existing pathways.

    Antonio del Sol;Chung-Jung Tsai;Buyong Ma;Ruth Nussinov;Ruth Nussinov

  • FOLDING AND BINDING CASCADES : SHIFTS IN ENERGY LANDSCAPES

    Chung-Jung Tsai;Buyong Ma;Ruth Nussinov

  • A unified view of "how allostery works".

    Chung-Jung Tsai;Ruth Nussinov

  • Extended disordered proteins: targeting function with less scaffold

    Kannan Gunasekaran;Chung-Jung Tsai;Sandeep Kumar;David Zanuy

  • Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

    Chung-Jung Tsai;Antonio del Sol;Ruth Nussinov;Ruth Nussinov

  • Allostery in Its Many Disguises: From Theory to Applications

    Shoshana J. Wodak;Emanuele Paci;Nikolay V. Dokholyan;Nikolay V. Dokholyan;Igor N. Berezovsky

  • Theoretical study of the (H2O)6 cluster

    C.J. Tsai;K.D. Jordan

  • Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima.

    Chung-Jung Tsai;Zuben E. Sauna;Chava Kimchi-Sarfaty;Suresh V. Ambudkar

  • Use of an eigenmode method to locate the stationary points on the potential energy surfaces of selected argon and water clusters

    C. J. Tsai;K. D. Jordan

  • Theoretical study of small water clusters : low-energy fused cubic structures for (H2O)n, n = 8, 12, 16, and 20

    C. J. Tsai;K. D. Jordan

  • A new, structurally nonredundant, diverse data set of protein–protein interfaces and its implications

    Ozlem Keskin;Ozlem Keskin;Chung-Jung Tsai;Haim Wolfson;Ruth Nussinov;Ruth Nussinov

  • Allostery without a conformational change? Revisiting the paradigm.

    Ruth Nussinov;Ruth Nussinov;Chung-Jung Tsai

Frequent Co-Authors

Ruth Nussinov
Ruth Nussinov National Institutes of Health
Buyong Ma
Buyong Ma Shanghai Jiao Tong University
Hyunbum Jang
Hyunbum Jang Leidos (United States)
Haim J. Wolfson
Haim J. Wolfson Tel Aviv University
Ozlem Keskin
Ozlem Keskin Koç University
Attila Gursoy
Attila Gursoy Koç University
Jie Zheng
Jie Zheng University of Akron
David Fushman
David Fushman University of Maryland, College Park
Feixiong Cheng
Feixiong Cheng Case Western Reserve University
Jacob V. Maizel
Jacob V. Maizel National Institutes of Health

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