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Chemistry

D-Index
55
Citations
11648
World Ranking
12058
National Ranking
3234

Overview

David Fushman is affiliated with the University of Maryland, College Park in the United States. Their research primarily falls within the broad field of Biochemistry, Genetics, and Molecular Biology, with a significant focus on several subfields such as Molecular Biology, Cell Biology, Immunology, Oncology, and Materials Chemistry.

Their scholarly output covers a range of topics including:

  • Ubiquitin and proteasome pathways
  • RNA and protein synthesis mechanisms
  • Protein Structure and Dynamics
  • Cancer-related Molecular Pathways
  • Enzyme Structure and Function
  • Autophagy in Disease and Therapy
  • Genomics and Chromatin Dynamics

David Fushman has contributed to several journals and venues with repeated publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Biochemistry
  • RSC Chemical Biology
  • Current Opinion in Structural Biology

Some of the most recent papers authored or co-authored by David Fushman include:

  • "Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin," 2023, Nature Communications
  • "Mechanism of Catalysis by l-Asparaginase," 2020, Biochemistry
  • "Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain," 2020, Nature Communications
  • "High-Affinity Interactions of the nSH3/cSH3 Domains of Grb2 with the C-Terminal Proline-Rich Domain of SOS1," 2020, Journal of the American Chemical Society
  • "In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides," 2020, RSC Chemical Biology

Frequent collaborators working with David Fushman include:

  • Christina M. Camara
  • Dulith Abeykoon
  • Betsegaw E. Lemma
  • Westley Pawloski
  • Haiqing Zhao

Best Publications

  • Polyubiquitin chains: polymeric protein signals

    Cecile M Pickart;David Fushman

  • Solution Conformation of Lys63-linked Di-ubiquitin Chain Provides Clues to Functional Diversity of Polyubiquitin Signaling

    Ranjani Varadan;Michael Assfalg;Aydin Haririnia;Shahri Raasi

  • Diverse polyubiquitin interaction properties of ubiquitin-associated domains.

    Shahri Raasi;Ranjani Varadan;David Fushman;Cecile M Pickart

  • Structural properties of polyubiquitin chains in solution.

    Ranjani Varadan;Olivier Walker;Cecile Pickart;David Fushman

  • Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

    Jie Zheng;Sean M. Cahill;Mark A. Lemmon;David Fushman

  • Structural Determinants for Selective Recognition of a Lys48-Linked Polyubiquitin Chain by a UBA Domain

    Ranjani Varadan;Michael Assfalg;Shahri Raasi;Cecile Pickart

  • Analyses of the Effects of All Ubiquitin Point Mutants on Yeast Growth Rate

    Benjamin P. Roscoe;Kelly M. Thayer;Konstantin B. Zeldovich;David Fushman

  • The main-chain dynamics of the dynamin pleckstrin homology (PH) domain in solution: analysis of 15N relaxation with monomer/dimer equilibration

    David Fushman;Sean Cahill;David Cowburn

  • Atom-by-atom analysis of global downhill protein folding.

    Mourad Sadqi;David Fushman;Victor Muñoz

  • Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain

    Rati Verma;Noel R. Peters;Mariapina D'Onofrio;Gregory P. Tochtrop

  • Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH.

    Michael J. Eddins;Ranjani Varadan;David Fushman;Cecile M. Pickart

  • Direct Measurement of 15N Chemical Shift Anisotropy in Solution

    David Fushman;Nico Tjandra;David Cowburn

  • Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains.

    Daoning Zhang;Shahri Raasi;David Fushman

  • Characterization of the overall and local dynamics of a protein with intermediate rotational anisotropy: Differentiating between conformational exchange and anisotropic diffusion in the B3 domain of protein G.

    Jennifer B. Hall;David Fushman

  • Evidence for Bidentate Substrate Binding as the Basis for the K48 Linkage Specificity of Otubain 1

    Tao Wang;Luming Yin;Eric M. Cooper;Ming Yih Lai

  • Structure of the S5a:K48-linked diubiquitin complex and its interactions with Rpn13

    Naixia Zhang;Qinghua Wang;Aaron Ehlinger;Leah Randles

  • Backbone dynamics of ribonuclease T1 and its complex with 2'GMP studied by two-dimensional heteronuclear NMR spectroscopy.

    David Fushman;Rüdiger Weisemann;Harald Thüring;Heinz Rüterjans

  • DIRECT DETERMINATION OF CHANGES OF INTERDOMAIN ORIENTATION ON LIGATION : USE OF THE ORIENTATIONAL DEPENDENCE OF 15N NMR RELAXATION IN ABL SH(32)

    David Fushman;Rong Xu;David Cowburn

  • Together, Rpn10 and Dsk2 Can Serve as a Polyubiquitin Chain-Length Sensor

    Daoning Zhang;Tony Chen;Inbal Ziv;Rina Rosenzweig

  • Rescuing a destabilized protein fold through backbone cyclization.

    Julio A Camarero;David Fushman;Satoshi Sato;Izabela Giriat

  • Determining domain orientation in macromolecules by using spin-relaxation and residual dipolar coupling measurements

    David Fushman;Ranjani Varadan;Michael Assfalg;Olivier Walker

Frequent Co-Authors

David Cowburn
David Cowburn Albert Einstein College of Medicine
Ruth Nussinov
Ruth Nussinov National Institutes of Health
Hyunbum Jang
Hyunbum Jang Leidos (United States)
Michael H. Glickman
Michael H. Glickman Technion – Israel Institute of Technology
Ashraf Brik
Ashraf Brik Technion – Israel Institute of Technology
Cecile M. Pickart
Cecile M. Pickart Johns Hopkins University
Aaron Ciechanover
Aaron Ciechanover Technion – Israel Institute of Technology
Chung-Jung Tsai
Chung-Jung Tsai Leidos (United States)
Raymond J. Deshaies
Raymond J. Deshaies California Institute of Technology
Julio A. Camarero
Julio A. Camarero University of Southern California

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