What is he best known for?
The fields of study he is best known for:
His main research concerns Ubiquitin, Biochemistry, Proteasome, Cell biology and Proteasome inhibitor.
His studies deal with areas such as Proteases and Cancer research as well as Ubiquitin.
Many of his studies on Biochemistry apply to Stereochemistry as well.
His Proteasome study combines topics in areas such as Cell, Cell culture, NFKB1, Proteomics and Chemical ligation.
Huib Ovaa combines subjects such as Cytotoxic T cell, IL-2 receptor, Antigen-presenting cell, Protease and Immune system with his study of Cell biology.
His study looks at the relationship between Proteasome inhibitor and fields such as Bortezomib, as well as how they intersect with chemical problems.
His most cited work include:
- A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib (590 citations)
- Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family (435 citations)
- Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome (354 citations)
What are the main themes of his work throughout his whole career to date?
Huib Ovaa mostly deals with Ubiquitin, Biochemistry, Cell biology, Proteasome and Deubiquitinating enzyme.
His biological study spans a wide range of topics, including Proteases, Enzyme, Computational biology and Stereochemistry.
His Autotaxin, Active site, Small molecule and Ubiquitin-conjugating enzyme study in the realm of Biochemistry connects with subjects such as Activity-based proteomics.
His Cell biology study combines topics from a wide range of disciplines, such as Protease and Immune system.
His Proteasome study focuses on Proteasome inhibitor in particular.
He studied Proteasome inhibitor and Bortezomib that intersect with Pharmacology.
He most often published in these fields:
- Ubiquitin (48.09%)
- Biochemistry (33.44%)
- Cell biology (29.62%)
What were the highlights of his more recent work (between 2018-2021)?
- Ubiquitin (48.09%)
- Cell biology (29.62%)
- Stereochemistry (15.29%)
In recent papers he was focusing on the following fields of study:
Huib Ovaa mainly focuses on Ubiquitin, Cell biology, Stereochemistry, Enzyme and Deubiquitinating enzyme.
His research integrates issues of DNA damage, Legionella, Lysine, Computational biology and Effector in his study of Ubiquitin.
His studies in Cell biology integrate themes in fields like Proteases and SUMO protein.
His study looks at the relationship between Stereochemistry and topics such as Covalent bond, which overlap with Cysteine and Electrophile.
His study on Enzyme is covered under Biochemistry.
The various areas that Huib Ovaa examines in his Deubiquitinating enzyme study include Combinatorial chemistry, Selectivity, Biophysics and Protein structure.
Between 2018 and 2021, his most popular works were:
- Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. (157 citations)
- Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons. (82 citations)
- Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. (67 citations)
In his most recent research, the most cited papers focused on:
Huib Ovaa focuses on Ubiquitin, Deubiquitinating enzyme, Protease, Cell biology and Small molecule.
Huib Ovaa has included themes like Protein structure, Biophysics, Computational biology and Proteasome in his Ubiquitin study.
The Proteasome study combines topics in areas such as Cellular pathways, NEDD8 and ENCODE.
Huib Ovaa works mostly in the field of Deubiquitinating enzyme, limiting it down to topics relating to Combinatorial chemistry and, in certain cases, Reagent, Enzyme, HEK 293 cells and Pyrophosphatase.
His work on Endocytosis expands to the thematically related Cell biology.
Papain is a subfield of Biochemistry that Huib Ovaa tackles.
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