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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
87
Citations
25924
World Ranking
2847
National Ranking
72

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

Huib Ovaa was affiliated with Leiden University Medical Center in the Netherlands. Their research spanned several fields focused on molecular processes related to immune responses, infectious diseases, and protein regulation.

The scientist contributed extensively to the study of SARS-CoV-2 and COVID-19, with research addressing viral mechanisms and immune activation. Notable publications include:

  • Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity, 2020, Nature
  • Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2, 2020, The EMBO Journal
  • Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features, 2021, Nature Communications

Ovaa's work also investigated protein degradation pathways and immune regulation, as illustrated by papers such as:

  • Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly, 2021, Nature
  • Opportunities for Small Molecules in Cancer Immunotherapy, 2020, Trends in Immunology

Their research focused on several main topics including:

  • Ubiquitin and proteasome pathways
  • Interferon and immune responses
  • SARS-CoV-2 and COVID-19 research
  • Immunotherapy and immune responses
  • Peptidase inhibition and analysis
  • Autophagy in disease and therapy
  • Protein degradation and inhibitors

Huib Ovaa's primary fields of study included Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Subfields represented in their work were Molecular Biology, Immunology, Oncology, Infectious Diseases, and Cell Biology.

The scientist published in venues such as bioRxiv, ChemBioChem, Frontiers in Chemistry, The EMBO Journal, and Nature Communications. They collaborated frequently with several researchers, including Paul P. Geurink, Gerbrand J. van der Heden van Noort, Cami Talavera Ormeño, Ayşegül Sapmaz, and Monique P. C. Mulder.

Best Publications

  • Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.

    Donghyuk Shin;Donghyuk Shin;Rukmini Mukherjee;Diana Grewe;Denisa Bojkova

  • A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

    Dharminder Chauhan;Laurence Catley;Guilan Li;Klaus Podar

  • Generation of peptide-MHC class I complexes through UV-mediated ligand exchange.

    Boris Rodenko;Mireille Toebes;Sine Reker Hadrup;Wim J E van Esch

  • Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family

    Anna Borodovsky;Huib Ovaa;Nagamalleswari Kolli;Tudeviin Gan-Erdene

  • Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome

    Michael Groll;Celia R. Berkers;Hidde L. Ploegh;Huib Ovaa

  • OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

    Tycho E.T. Mevissen;Manuela K. Hospenthal;Paul P. Geurink;Paul R. Elliott

  • Proteome-wide identification of ubiquitin interactions using UbIA-MS

    Xiaofei Zhang;Xiaofei Zhang;Arne H Smits;Gabrielle Ba van Tilburg;Huib Ovaa

  • Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

    Baoxu Pang;Xiaohang Qiao;Lennert Janssen;Arno Velds

  • Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.

    Theresa Klemm;Gregor Ebert;Dale J Calleja;Cody C Allison

  • Design and use of conditional MHC class I ligands

    Mireille Toebes;Miriam Coccoris;Adriaan Bins;Boris Rodenko

  • On Terminal Alkynes that Can React with Active-Site Cysteine Nucleophiles in Proteases.

    Reggy Ekkebus;Sander I. van Kasteren;Yogesh Kulathu;Arjen Scholten

  • Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

    Jorg van Loosdregt;Veerle Fleskens;Juan Fu;Arjan B. Brenkman

  • Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

    Erik Meulmeester;Madelon M. Maurice;Chris Boutell;Amina F.A.S. Teunisse

  • Structural basis of substrate discrimination and integrin binding by autotaxin

    Jens Hausmann;Satwik Kamtekar;Evangelos Christodoulou;Jacqueline E Day

  • Disease-Associated Prion Protein Oligomers Inhibit the 26S Proteasome

    Mark Kristiansen;Pelagia Deriziotis;Derek E. Dimcheff;Graham S. Jackson

  • Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin

    Farid El Oualid;Remco Merkx;Reggy Ekkebus;Dharjath S. Hameed

  • Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

    Celia R Berkers;Martijn Verdoes;Martijn Verdoes;Eben Lichtman;Edda Fiebiger

  • CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib.

    Roberto Piva;Roberto Piva;Bruce Ruggeri;Michael Williams;Giulia Costa

  • Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation

    Marc Schmidt-Supprian;Jane Tian;Ethan P. Grant;Manolis Pasparakis

  • Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity.

    Paul C. Evans;Huib Ovaa;Maureen Hamon;Peter J. Kilshaw

Frequent Co-Authors

Jacques Neefjes
Jacques Neefjes Leiden University Medical Center
David Komander
David Komander Walter and Eliza Hall Institute of Medical Research
Hidde L. Ploegh
Hidde L. Ploegh Boston Children's Hospital
Herman S. Overkleeft
Herman S. Overkleeft Leiden University
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
Titia K. Sixma
Titia K. Sixma Antoni van Leeuwenhoek Hospital
Ton N. M. Schumacher
Ton N. M. Schumacher Antoni van Leeuwenhoek Hospital
Stefan M.V. Freund
Stefan M.V. Freund MRC Laboratory of Molecular Biology
Gideon J. Davies
Gideon J. Davies University of York
Johannes M. F. G. Aerts
Johannes M. F. G. Aerts Leiden University

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