World's Best Scientists 2026 revealed!
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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
87
Citations
25924
World Ranking
2847
National Ranking
72

Huib Ovaa publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Huib Ovaa sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 329 publications — 83rd percentile

83% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Huib Ovaa D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Huib Ovaa sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 87 D-Index — 86th percentile

86% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

Huib Ovaa was affiliated with Leiden University Medical Center in the Netherlands. Their research spanned several fields focused on molecular processes related to immune responses, infectious diseases, and protein regulation.

The scientist contributed extensively to the study of SARS-CoV-2 and COVID-19, with research addressing viral mechanisms and immune activation. Notable publications include:

  • Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity, 2020, Nature
  • Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2, 2020, The EMBO Journal
  • Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features, 2021, Nature Communications

Ovaa's work also investigated protein degradation pathways and immune regulation, as illustrated by papers such as:

  • Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly, 2021, Nature
  • Opportunities for Small Molecules in Cancer Immunotherapy, 2020, Trends in Immunology

Their research focused on several main topics including:

  • Ubiquitin and proteasome pathways
  • Interferon and immune responses
  • SARS-CoV-2 and COVID-19 research
  • Immunotherapy and immune responses
  • Peptidase inhibition and analysis
  • Autophagy in disease and therapy
  • Protein degradation and inhibitors

Huib Ovaa's primary fields of study included Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Subfields represented in their work were Molecular Biology, Immunology, Oncology, Infectious Diseases, and Cell Biology.

The scientist published in venues such as bioRxiv, ChemBioChem, Frontiers in Chemistry, The EMBO Journal, and Nature Communications. They collaborated frequently with several researchers, including Paul P. Geurink, Gerbrand J. van der Heden van Noort, Cami Talavera Ormeño, Ayşegül Sapmaz, and Monique P. C. Mulder.

Best Publications

  • Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.

    Donghyuk Shin;Donghyuk Shin;Rukmini Mukherjee;Diana Grewe;Denisa Bojkova

  • A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

    Dharminder Chauhan;Laurence Catley;Guilan Li;Klaus Podar

  • Generation of peptide-MHC class I complexes through UV-mediated ligand exchange.

    Boris Rodenko;Mireille Toebes;Sine Reker Hadrup;Wim J E van Esch

  • Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family

    Anna Borodovsky;Huib Ovaa;Nagamalleswari Kolli;Tudeviin Gan-Erdene

  • Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome

    Michael Groll;Celia R. Berkers;Hidde L. Ploegh;Huib Ovaa

  • OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

    Tycho E.T. Mevissen;Manuela K. Hospenthal;Paul P. Geurink;Paul R. Elliott

  • Proteome-wide identification of ubiquitin interactions using UbIA-MS

    Xiaofei Zhang;Xiaofei Zhang;Arne H Smits;Gabrielle Ba van Tilburg;Huib Ovaa

  • Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

    Baoxu Pang;Xiaohang Qiao;Lennert Janssen;Arno Velds

  • Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.

    Theresa Klemm;Gregor Ebert;Dale J Calleja;Cody C Allison

  • Design and use of conditional MHC class I ligands

    Mireille Toebes;Miriam Coccoris;Adriaan Bins;Boris Rodenko

  • On Terminal Alkynes that Can React with Active-Site Cysteine Nucleophiles in Proteases.

    Reggy Ekkebus;Sander I. van Kasteren;Yogesh Kulathu;Arjen Scholten

  • Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

    Jorg van Loosdregt;Veerle Fleskens;Juan Fu;Arjan B. Brenkman

  • Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

    Erik Meulmeester;Madelon M. Maurice;Chris Boutell;Amina F.A.S. Teunisse

  • Structural basis of substrate discrimination and integrin binding by autotaxin

    Jens Hausmann;Satwik Kamtekar;Evangelos Christodoulou;Jacqueline E Day

  • Disease-Associated Prion Protein Oligomers Inhibit the 26S Proteasome

    Mark Kristiansen;Pelagia Deriziotis;Derek E. Dimcheff;Graham S. Jackson

  • Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin

    Farid El Oualid;Remco Merkx;Reggy Ekkebus;Dharjath S. Hameed

  • Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

    Celia R Berkers;Martijn Verdoes;Martijn Verdoes;Eben Lichtman;Edda Fiebiger

  • CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib.

    Roberto Piva;Roberto Piva;Bruce Ruggeri;Michael Williams;Giulia Costa

  • Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation

    Marc Schmidt-Supprian;Jane Tian;Ethan P. Grant;Manolis Pasparakis

  • Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity.

    Paul C. Evans;Huib Ovaa;Maureen Hamon;Peter J. Kilshaw

Frequent Co-Authors

Jacques Neefjes
Jacques Neefjes Leiden University Medical Center
David Komander
David Komander Walter and Eliza Hall Institute of Medical Research
Hidde L. Ploegh
Hidde L. Ploegh Boston Children's Hospital
Herman S. Overkleeft
Herman S. Overkleeft Leiden University
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
Titia K. Sixma
Titia K. Sixma Antoni van Leeuwenhoek Hospital
Ton N. M. Schumacher
Ton N. M. Schumacher Antoni van Leeuwenhoek Hospital
Stefan M.V. Freund
Stefan M.V. Freund MRC Laboratory of Molecular Biology
Gideon J. Davies
Gideon J. Davies University of York
Johannes M. F. G. Aerts
Johannes M. F. G. Aerts Leiden University

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