2023 - Research.com Biology and Biochemistry in Netherlands Leader Award
His main research concerns Ubiquitin, Biochemistry, Proteasome, Cell biology and Proteasome inhibitor. His studies deal with areas such as Proteases and Cancer research as well as Ubiquitin. Many of his studies on Biochemistry apply to Stereochemistry as well.
His Proteasome study combines topics in areas such as Cell, Cell culture, NFKB1, Proteomics and Chemical ligation. Huib Ovaa combines subjects such as Cytotoxic T cell, IL-2 receptor, Antigen-presenting cell, Protease and Immune system with his study of Cell biology. His study looks at the relationship between Proteasome inhibitor and fields such as Bortezomib, as well as how they intersect with chemical problems.
Huib Ovaa mostly deals with Ubiquitin, Biochemistry, Cell biology, Proteasome and Deubiquitinating enzyme. His biological study spans a wide range of topics, including Proteases, Enzyme, Computational biology and Stereochemistry. His Autotaxin, Active site, Small molecule and Ubiquitin-conjugating enzyme study in the realm of Biochemistry connects with subjects such as Activity-based proteomics.
His Cell biology study combines topics from a wide range of disciplines, such as Protease and Immune system. His Proteasome study focuses on Proteasome inhibitor in particular. He studied Proteasome inhibitor and Bortezomib that intersect with Pharmacology.
Huib Ovaa mainly focuses on Ubiquitin, Cell biology, Stereochemistry, Enzyme and Deubiquitinating enzyme. His research integrates issues of DNA damage, Legionella, Lysine, Computational biology and Effector in his study of Ubiquitin. His studies in Cell biology integrate themes in fields like Proteases and SUMO protein.
His study looks at the relationship between Stereochemistry and topics such as Covalent bond, which overlap with Cysteine and Electrophile. His study on Enzyme is covered under Biochemistry. The various areas that Huib Ovaa examines in his Deubiquitinating enzyme study include Combinatorial chemistry, Selectivity, Biophysics and Protein structure.
Huib Ovaa focuses on Ubiquitin, Deubiquitinating enzyme, Protease, Cell biology and Small molecule. Huib Ovaa has included themes like Protein structure, Biophysics, Computational biology and Proteasome in his Ubiquitin study. The Proteasome study combines topics in areas such as Cellular pathways, NEDD8 and ENCODE.
Huib Ovaa works mostly in the field of Deubiquitinating enzyme, limiting it down to topics relating to Combinatorial chemistry and, in certain cases, Reagent, Enzyme, HEK 293 cells and Pyrophosphatase. His work on Endocytosis expands to the thematically related Cell biology. Papain is a subfield of Biochemistry that Huib Ovaa tackles.
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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
Dharminder Chauhan;Laurence Catley;Guilan Li;Klaus Podar.
Cancer Cell (2005)
Generation of peptide-MHC class I complexes through UV-mediated ligand exchange.
Boris Rodenko;Mireille Toebes;Sine Reker Hadrup;Wim J E van Esch.
Nature Protocols (2006)
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Donghyuk Shin;Donghyuk Shin;Rukmini Mukherjee;Diana Grewe;Denisa Bojkova.
Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family
Anna Borodovsky;Huib Ovaa;Nagamalleswari Kolli;Tudeviin Gan-Erdene.
Chemistry & Biology (2002)
Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome
Michael Groll;Celia R. Berkers;Hidde L. Ploegh;Huib Ovaa.
OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis
Tycho E.T. Mevissen;Manuela K. Hospenthal;Paul P. Geurink;Paul R. Elliott.
Design and use of conditional MHC class I ligands
Mireille Toebes;Miriam Coccoris;Adriaan Bins;Boris Rodenko.
Nature Medicine (2006)
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
Erik Meulmeester;Madelon M. Maurice;Chris Boutell;Amina F.A.S. Teunisse.
Molecular Cell (2005)
Disease-Associated Prion Protein Oligomers Inhibit the 26S Proteasome
Mark Kristiansen;Pelagia Deriziotis;Derek E. Dimcheff;Graham S. Jackson.
Molecular Cell (2007)
CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib.
Roberto Piva;Roberto Piva;Bruce Ruggeri;Michael Williams;Giulia Costa.
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