Benedikt M. Kessler

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
• 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

Best Publications

• Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.

  Haim Y. Cohen;Christine Miller;Kevin J. Bitterman;Nathan R. Wall

  2369
  Citations

• Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

  Evanna L Mills;Dylan G Ryan;Hiran A Prag;Dina Dikovskaya

  1783
  Citations

• Broad and strong memory CD4 + and CD8 + T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.

  Y Peng;A J Mentzer;G Liu;G Liu;X Yao

  1277
  Citations

• Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

  Neil P. Blackledge;Anca M. Farcas;Takashi Kondo;Hamish W. King

  768
  Citations

• Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.

  Haim Y Cohen;Siva Lavu;Kevin J Bitterman;Brian Hekking

  760
  Citations

• Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family

  Anna Borodovsky;Huib Ovaa;Nagamalleswari Kolli;Tudeviin Gan-Erdene

  664
  Citations

• Colonic epithelial cell diversity in health and inflammatory bowel disease

  Kaushal Parikh;Kaushal Parikh;Agne Antanaviciute;Agne Antanaviciute;David Fawkner-Corbett;David Fawkner-Corbett;David Fawkner-Corbett;Marta Jagielowicz;Marta Jagielowicz

  634
  Citations

• Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

  Julie Adam;Emine Hatipoglu;Linda O'Flaherty;Nicola Ternette

  621
  Citations

• A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.

  Anna Borodovsky;Benedikt M. Kessler;Rocco Casagrande;Herman S. Overkleeft

  583
  Citations

• A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

  Dharminder Chauhan;Ze Tian;Benjamin Nicholson;K.G. Suresh Kumar

  560
  Citations

• Arginine methylation regulates the p53 response

  Martin Jansson;Stephen T. Durant;Er Chieh Cho;Sharon Sheahan

  549
  Citations

• KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

  Anca M Farcas;Neil P Blackledge;Ian Sudbery;Hannah K Long;Hannah K Long

  477
  Citations

• Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

  Celia J. Webby;Alexander Wolf;Natalia Gromak;Mathias Dreger

  469
  Citations

• Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo.

  M. Mortensen;D.J.P. Ferguson;M. Edelmann;B. Kessler

  455
  Citations

• New mechanism for notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

  Helen Sheldon;Emily Heikamp;Helen Turley;Rebecca Dragovic

  448
  Citations

• Neuronal loss and brain atrophy in mice lacking cathepsins B and L.

  Ute Felbor;Benedikt Kessler;Walther Mothes;Hans H. Goebel

  406
  Citations

• Molecular basis of USP7 inhibition by selective small-molecule inhibitors

  Andrew P. Turnbull;Stephanos Ioannidis;Wojciech W. Krajewski;Adan Pinto-Fernandez

  405
  Citations

• Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

  Mikael Altun;Holger B. Kramer;Lianne I. Willems;Jeffrey L. McDermott

  387
  Citations

• Ancient proteins resolve the evolutionary history of Darwin’s South American ungulates

  Frido Welker;Matthew J. Collins;Jessica A. Thomas;Marc Wadsley

  377
  Citations

• Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

  Celia R Berkers;Martijn Verdoes;Martijn Verdoes;Eben Lichtman;Edda Fiebiger

  314
  Citations