World's Best Scientists 2026 revealed!
Leonard Guarente

Leonard Guarente

Award Badge
Genetics
USA
2026

D-Index & Metrics

Genetics

D-Index
158
Citations
113048
World Ranking
105
National Ranking
53

Research.com Recognitions

  • 2026 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Genetics in United States Leader Award
  • 2024 - Research.com Genetics in United States Leader Award
  • 2023 - Research.com Genetics in United States Leader Award
  • 2004 - Fellow of the American Academy of Arts and Sciences

Overview

Leonard Guarente is affiliated with MIT in the United States and has a research focus primarily within the fields of Medicine and Health Professions. Their work spans several subfields including General Health Professions, Infectious Diseases, Applied Microbiology and Biotechnology, Critical Care and Intensive Care Medicine, and Economics and Econometrics.

Their research addresses multiple topics, notably Antibiotic Use and Resistance, Healthcare cost, quality, practices, Nosocomial Infections in ICU, Healthcare Education and Workforce Issues, Infection Control in Healthcare, Clostridium difficile and Clostridium perfringens research, and Healthcare Policy and Management.

Leonard Guarente has coauthored multiple publications alongside several frequent collaborators including Mariachiara Carestia, Fausto Ciccacci, Stefano Orlando, Leonardo Palombi, and Leonardo Emberti Gialloreti.

Recent papers authored with colleagues cover various aspects of healthcare-associated infections and healthcare environments:

  • A novel, integrated approach for understanding and investigating Healthcare Associated Infections: A risk factors constellation analysis, 2023, PLoS ONE
  • Not only COVID-19: a systematic review of anti-COVID-19 measures and their effect on healthcare-associated infections, 2024, Journal of Hospital Infection
  • The financial burden of healthcare-associated infections: a propensity score analysis in an Italian healthcare setting, 2024, Infection Prevention in Practice
  • Appraisal and Evaluation of the Learning Environment Instruments of the Student Nurse: A Systematic Review Using COSMIN Methodology, 2023, Healthcare
  • Evaluation of Standard Precautions Compliance Instruments: A Systematic Review Using COSMIN Methodology, 2023, Healthcare

The frequent venues for their work include Infection Prevention in Practice, Healthcare, Journal of Hospital Infection, PLoS ONE, and JMIR Research Protocols.

Leonard Guarente was recognized as a Fellow of the American Academy of Arts and Sciences in 2004.

Best Publications

  • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

    Shin-ichiro Imai;Christopher M. Armstrong;Matt Kaeberlein;Leonard Guarente

  • hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

    Homayoun Vaziri;Scott K. Dessain;Scott K. Dessain;Elinor Ng Eaton;Shin Ichiro Imai

  • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

    Heidi A. Tissenbaum;Leonard Guarente

  • Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

    Jianyuan Luo;Anatoly Y. Nikolaev;Shin ichiro Imai;Delin Chen

  • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

    Matt Kaeberlein;Mitch McVey;Leonard Guarente

  • Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.

    Frédéric Picard;Martin Kurtev;Namjin Chung;Acharawan Topark-Ngarm

  • The Sir2 Family of Protein Deacetylases

    Gil Blander;Leonard Guarente

  • Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

    Su Ju Lin;Pierre Antoine Defossez;Leonard Guarente

  • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

    Christian M. Metallo;Paulo A. Gameiro;Eric L. Bell;Katherine R. Mattaini

  • Genetic pathways that regulate ageing in model organisms

    Leonard Guarente;Cynthia Kenyon

  • Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

    Raul Mostoslavsky;Katrin F. Chua;Katrin F. Chua;David B. Lombard;Wendy W. Pang

  • Extrachromosomal rDNA circles--a cause of aging in yeast.

    David A Sinclair;Leonard Guarente

  • Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction

    Marcia C. Haigis;Leonard P. Guarente

  • Mammalian SIRT1 Represses Forkhead Transcription Factors

    Maria Carla Motta;Nullin Divecha;Madeleine Lemieux;Christopher Kamel

  • The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

    Yasukazu Nakahata;Milota Kaluzova;Benedetto Grimaldi;Saurabh Sahar

  • Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast.

    Leonard Guarente

  • Five intermediate complexes in transcription initiation by RNA polymerase II

    Stephen Buratowski;Steven Hahn;Leonard Guarente;Phillip A. Sharp

  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

    David B. Lombard;Frederick W. Alt;Hwei Ling Cheng;Jakob Bunkenborg

  • SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

    Marcia C. Haigis;Raul Mostoslavsky;Kevin M. Haigis;Kamau Fahie

  • Calorie restriction, SIRT1 and metabolism: understanding longevity

    Laura Bordone;Leonard Guarente

Frequent Co-Authors

David A. Sinclair
David A. Sinclair Harvard University
Shin-ichiro Imai
Shin-ichiro Imai Washington University in St. Louis
Michael W. McBurney
Michael W. McBurney University of Ottawa
Mark Ptashne
Mark Ptashne Memorial Sloan Kettering Cancer Center
F. Brad Johnson
F. Brad Johnson University of Pennsylvania
Matt Kaeberlein
Matt Kaeberlein University of Washington
David B. Lombard
David B. Lombard University of Michigan–Ann Arbor
Steven Hahn
Steven Hahn Fred Hutchinson Cancer Research Center
Thomas M. Roberts
Thomas M. Roberts Harvard University

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