World's Best Scientists 2026 revealed!
Leonard Guarente

Leonard Guarente

Award Badge
Genetics
USA
2026

D-Index & Metrics

Genetics

D-Index
158
Citations
113048
World Ranking
105
National Ranking
53

Leonard Guarente publication distribution in Genetics in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Genetics in 2026. The highlighted bar marks where Leonard Guarente sits on this spectrum.

45–54 publications: 6 scientists 55–64 publications: 10 scientists 65–74 publications: 35 scientists 75–84 publications: 84 scientists 85–94 publications: 102 scientists 95–104 publications: 151 scientists 105–114 publications: 175 scientists 115–124 publications: 203 scientists 125–134 publications: 217 scientists 135–144 publications: 205 scientists 145–154 publications: 193 scientists 155–164 publications: 188 scientists 165–174 publications: 170 scientists 175–184 publications: 178 scientists 185–194 publications: 164 scientists 195–204 publications: 173 scientists 205–214 publications: 159 scientists 215–224 publications: 134 scientists 225–234 publications: 143 scientists 235–244 publications: 105 scientists 245–254 publications: 114 scientists 255–264 publications: 92 scientists 265–274 publications: 88 scientists 275–284 publications: 87 scientists 285–294 publications: 80 scientists 295–304 publications: 62 scientists 305–314 publications: 75 scientists 315–324 publications: 67 scientists 325–334 publications: 60 scientists 335–344 publications: 52 scientists 345–354 publications: 40 scientists 355–364 publications: 48 scientists 365–374 publications: 47 scientists 375–384 publications: 46 scientists 385–394 publications: 31 scientists 395–404 publications: 27 scientists 405–414 publications: 40 scientists 415–424 publications: 30 scientists 425–434 publications: 43 scientists 435–444 publications: 29 scientists 445–454 publications: 14 scientists 455–464 publications: 28 scientists 465–474 publications: 21 scientists 475–484 publications: 21 scientists 485–494 publications: 22 scientists 495–504 publications: 17 scientists 505–514 publications: 12 scientists 515–524 publications: 11 scientists 525–534 publications: 8 scientists 535–544 publications: 8 scientists 545–554 publications: 14 scientists 555–564 publications: 4 scientists 565–574 publications: 11 scientists 575–584 publications: 5 scientists 585–594 publications: 11 scientists 595–604 publications: 12 scientists 605–614 publications: 7 scientists 615–624 publications: 6 scientists 625–634 publications: 10 scientists 635–644 publications: 9 scientists 645–654 publications: 10 scientists 655–664 publications: 6 scientists 665–674 publications: 6 scientists 675–684 publications: 6 scientists 685–694 publications: 4 scientists 695–702 publications: 6 scientists 703+ publications: 100 scientists
45 publications 703+

This scientist: 328 publications — 80th percentile

80% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 703 publications or more.

Leonard Guarente D-index placement in Genetics in 2026

The chart shows the D-index (discipline H-index) distribution of Genetics scientists ranked by Research.com in 2026. The highlighted bar marks where Leonard Guarente sits on this spectrum.

40–41 D-Index: 24 scientists 42–43 D-Index: 52 scientists 44–45 D-Index: 84 scientists 46–47 D-Index: 112 scientists 48–49 D-Index: 118 scientists 50–51 D-Index: 141 scientists 52–53 D-Index: 143 scientists 54–55 D-Index: 145 scientists 56–57 D-Index: 179 scientists 58–59 D-Index: 162 scientists 60–61 D-Index: 175 scientists 62–63 D-Index: 191 scientists 64–65 D-Index: 172 scientists 66–67 D-Index: 184 scientists 68–69 D-Index: 164 scientists 70–71 D-Index: 158 scientists 72–73 D-Index: 150 scientists 74–75 D-Index: 136 scientists 76–77 D-Index: 127 scientists 78–79 D-Index: 127 scientists 80–81 D-Index: 111 scientists 82–83 D-Index: 110 scientists 84–85 D-Index: 110 scientists 86–87 D-Index: 84 scientists 88–89 D-Index: 102 scientists 90–91 D-Index: 66 scientists 92–93 D-Index: 72 scientists 94–95 D-Index: 70 scientists 96–97 D-Index: 54 scientists 98–99 D-Index: 60 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 55 scientists 104–105 D-Index: 45 scientists 106–107 D-Index: 42 scientists 108–109 D-Index: 28 scientists 110–111 D-Index: 39 scientists 112–113 D-Index: 25 scientists 114–115 D-Index: 31 scientists 116–117 D-Index: 29 scientists 118–119 D-Index: 34 scientists 120–121 D-Index: 29 scientists 122–123 D-Index: 29 scientists 124–125 D-Index: 18 scientists 126–127 D-Index: 27 scientists 128–129 D-Index: 22 scientists 130–131 D-Index: 16 scientists 132–133 D-Index: 11 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 12 scientists 138–139 D-Index: 21 scientists 140–141 D-Index: 4 scientists 142–143 D-Index: 9 scientists 144–145 D-Index: 14 scientists 146–147 D-Index: 6 scientists 148–149 D-Index: 10 scientists 150–151 D-Index: 7 scientists 152–153 D-Index: 9 scientists 154–155 D-Index: 8 scientists 156–157 D-Index: 8 scientists 158–159 D-Index: 9 scientists 160+ D-Index: 96 scientists
40 D-Index 160+

This scientist: 158 D-Index — 98th percentile

98% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 160 D-Index or more.

Research.com Recognitions

  • 2026 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Genetics in United States Leader Award
  • 2024 - Research.com Genetics in United States Leader Award
  • 2023 - Research.com Genetics in United States Leader Award
  • 2004 - Fellow of the American Academy of Arts and Sciences

Overview

Leonard Guarente is affiliated with MIT in the United States and has a research focus primarily within the fields of Medicine and Health Professions. Their work spans several subfields including General Health Professions, Infectious Diseases, Applied Microbiology and Biotechnology, Critical Care and Intensive Care Medicine, and Economics and Econometrics.

Their research addresses multiple topics, notably Antibiotic Use and Resistance, Healthcare cost, quality, practices, Nosocomial Infections in ICU, Healthcare Education and Workforce Issues, Infection Control in Healthcare, Clostridium difficile and Clostridium perfringens research, and Healthcare Policy and Management.

Leonard Guarente has coauthored multiple publications alongside several frequent collaborators including Mariachiara Carestia, Fausto Ciccacci, Stefano Orlando, Leonardo Palombi, and Leonardo Emberti Gialloreti.

Recent papers authored with colleagues cover various aspects of healthcare-associated infections and healthcare environments:

  • A novel, integrated approach for understanding and investigating Healthcare Associated Infections: A risk factors constellation analysis, 2023, PLoS ONE
  • Not only COVID-19: a systematic review of anti-COVID-19 measures and their effect on healthcare-associated infections, 2024, Journal of Hospital Infection
  • The financial burden of healthcare-associated infections: a propensity score analysis in an Italian healthcare setting, 2024, Infection Prevention in Practice
  • Appraisal and Evaluation of the Learning Environment Instruments of the Student Nurse: A Systematic Review Using COSMIN Methodology, 2023, Healthcare
  • Evaluation of Standard Precautions Compliance Instruments: A Systematic Review Using COSMIN Methodology, 2023, Healthcare

The frequent venues for their work include Infection Prevention in Practice, Healthcare, Journal of Hospital Infection, PLoS ONE, and JMIR Research Protocols.

Leonard Guarente was recognized as a Fellow of the American Academy of Arts and Sciences in 2004.

Best Publications

  • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

    Shin-ichiro Imai;Christopher M. Armstrong;Matt Kaeberlein;Leonard Guarente

  • hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

    Homayoun Vaziri;Scott K. Dessain;Scott K. Dessain;Elinor Ng Eaton;Shin Ichiro Imai

  • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

    Heidi A. Tissenbaum;Leonard Guarente

  • Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

    Jianyuan Luo;Anatoly Y. Nikolaev;Shin ichiro Imai;Delin Chen

  • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

    Matt Kaeberlein;Mitch McVey;Leonard Guarente

  • Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.

    Frédéric Picard;Martin Kurtev;Namjin Chung;Acharawan Topark-Ngarm

  • The Sir2 Family of Protein Deacetylases

    Gil Blander;Leonard Guarente

  • Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

    Su Ju Lin;Pierre Antoine Defossez;Leonard Guarente

  • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

    Christian M. Metallo;Paulo A. Gameiro;Eric L. Bell;Katherine R. Mattaini

  • Genetic pathways that regulate ageing in model organisms

    Leonard Guarente;Cynthia Kenyon

  • Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

    Raul Mostoslavsky;Katrin F. Chua;Katrin F. Chua;David B. Lombard;Wendy W. Pang

  • Extrachromosomal rDNA circles--a cause of aging in yeast.

    David A Sinclair;Leonard Guarente

  • Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction

    Marcia C. Haigis;Leonard P. Guarente

  • Mammalian SIRT1 Represses Forkhead Transcription Factors

    Maria Carla Motta;Nullin Divecha;Madeleine Lemieux;Christopher Kamel

  • The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

    Yasukazu Nakahata;Milota Kaluzova;Benedetto Grimaldi;Saurabh Sahar

  • Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast.

    Leonard Guarente

  • Five intermediate complexes in transcription initiation by RNA polymerase II

    Stephen Buratowski;Steven Hahn;Leonard Guarente;Phillip A. Sharp

  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

    David B. Lombard;Frederick W. Alt;Hwei Ling Cheng;Jakob Bunkenborg

  • SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

    Marcia C. Haigis;Raul Mostoslavsky;Kevin M. Haigis;Kamau Fahie

  • Calorie restriction, SIRT1 and metabolism: understanding longevity

    Laura Bordone;Leonard Guarente

Frequent Co-Authors

David A. Sinclair
David A. Sinclair Harvard University
Shin-ichiro Imai
Shin-ichiro Imai Washington University in St. Louis
Michael W. McBurney
Michael W. McBurney University of Ottawa
Mark Ptashne
Mark Ptashne Memorial Sloan Kettering Cancer Center
F. Brad Johnson
F. Brad Johnson University of Pennsylvania
Matt Kaeberlein
Matt Kaeberlein University of Washington
David B. Lombard
David B. Lombard University of Michigan–Ann Arbor
Steven Hahn
Steven Hahn Fred Hutchinson Cancer Research Center
Thomas M. Roberts
Thomas M. Roberts Harvard University

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