World's Best Scientists 2026 revealed!
Raul Mostoslavsky

Raul Mostoslavsky

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
35589
World Ranking
7217
National Ranking
3309

Overview

Raul Mostoslavsky is affiliated with Harvard University in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans multiple subfields, including molecular biology, cancer research, geriatrics and gerontology, oncology, and infectious diseases.

The scientist's work touches on several prominent topics, such as:

  • Epigenetics and DNA Methylation
  • Sirtuins and Resveratrol in Medicine
  • RNA modifications and cancer
  • Cancer, Hypoxia, and Metabolism
  • Mitochondrial Function and Pathology
  • CRISPR and Genetic Engineering
  • PARP inhibition in cancer therapy

Raul Mostoslavsky has published in a variety of scientific venues, with a notably frequent presence in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Metabolism
  • Cell Metabolism
  • Cell
  • Molecular Cell

The scientist's recent papers include:

  • "Loss of epigenetic information as a cause of mammalian aging," 2023, Cell
  • "Nuclear metabolism and the regulation of the epigenome," 2020, Nature Metabolism
  • "NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer," 2023, Cell Metabolism
  • "SIRT6 is a key regulator of mitochondrial function in the brain," 2023, Cell Death and Disease
  • "NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer," 2021, Molecular Cell

Frequent collaborators include Ruben Boon, Ruslan I. Sadreyev, Tiziano Bernasocchi, Zhixun Dou, and Giórgia Gobbi da Silveira. These coauthors have worked with Mostoslavsky multiple times across various projects.

Best Publications

  • Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

    Anne Brunet;Lora B. Sweeney;J. Fitzhugh Sturgill;Katrin F. Chua

  • Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

    Raul Mostoslavsky;Katrin F. Chua;Katrin F. Chua;David B. Lombard;Wendy W. Pang

  • Recent progress in the biology and physiology of sirtuins

    Toren Finkel;Chu Xia Deng;Raul Mostoslavsky

  • A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

    In Hye Lee;Liu Cao;Raul Mostoslavsky;David B. Lombard

  • Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

    Zachary Gerhart-Hines;Zachary Gerhart-Hines;Joseph T. Rodgers;Joseph T. Rodgers;Olivia Bare;Carles Lerin;Carles Lerin

  • SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

    Gad Asher;David Gatfield;Markus Stratmann;Hans Reinke

  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

    David B. Lombard;Frederick W. Alt;Hwei Ling Cheng;Jakob Bunkenborg

  • SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

    Marcia C. Haigis;Raul Mostoslavsky;Kevin M. Haigis;Kamau Fahie

  • Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

    Hwei-Ling Cheng;Raul Mostoslavsky;Shin'ichi Saito;John P. Manis

  • DNA Repair, Genome Stability, and Aging

    David B. Lombard;Katrin F. Chua;Raul Mostoslavsky;Sonia Franco

  • The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

    Lei Zhong;Agustina D'Urso;Debra Toiber;Carlos Sebastian

  • SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

    Philipp Oberdoerffer;Shaday Michan;Michael McVay;Raul Mostoslavsky

  • SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

    Hong Jiang;Saba Khan;Yi Wang;Guillaume Charron

  • MECHANISM AND CONTROL OF V(D)J RECOMBINATION AT THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS

    David Jung;Cosmas Giallourakis;Raul Mostoslavsky;Frederick W. Alt

  • SIRT1 controls endothelial angiogenic functions during vascular growth

    Michael Potente;Laleh Ghaeni;Danila Baldessari;Raul Mostoslavsky

  • The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

    Carlos Sebastián;Bernardette M. M. Zwaans;Dafne Magali Silberman;Dafne Magali Silberman;Melissa Gymrek

  • The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

    Nagalingam R. Sundaresan;Prabhakaran Vasudevan;Lei Zhong;Gene Kim

  • Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes

    Jean Pierre Etchegaray;Raul Mostoslavsky;Raul Mostoslavsky

  • Chromatin and beyond: the multitasking roles for SIRT6.

    Sita Kugel;Raul Mostoslavsky

  • Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

    Virginia Guarani;Gianluca Deflorian;Claudio A Franco;Marcus Kruger

Frequent Co-Authors

Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
David B. Lombard
David B. Lombard University of Michigan–Ann Arbor
Ruslan I. Sadreyev
Ruslan I. Sadreyev Harvard University
Katrin F. Chua
Katrin F. Chua Stanford University
Nabeel Bardeesy
Nabeel Bardeesy Harvard University
Sridhar Ramaswamy
Sridhar Ramaswamy Harvard University
Graham Dellaire
Graham Dellaire Dalhousie University
Yehudit Bergman
Yehudit Bergman Hebrew University of Jerusalem
Howard Cedar
Howard Cedar Hebrew University of Jerusalem
Stefanie Dimmeler
Stefanie Dimmeler Goethe University Frankfurt

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