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Biology and Biochemistry

D-Index
76
Citations
19526
World Ranking
5077
National Ranking
2431

Overview

David Gius is affiliated with Northwestern University in the United States. Their research spans several areas within the biological and medical sciences, with a primary focus on biochemistry, genetics, and molecular biology, encompassing 29 publications. In addition, their work extends into the field of medicine, with 22 publications.

Their research subfields include molecular biology, physiology, cancer research, endocrinology, diabetes and metabolism, and epidemiology. More specifically, the subfield distribution shows 19 works in molecular biology, 11 in physiology, 6 in cancer research, 2 in endocrinology, diabetes and metabolism, and 2 in epidemiology.

Main research topics covered by David Gius include:

  • Cancer, Hypoxia, and Metabolism
  • Diet and Metabolism Studies
  • Mitochondrial Function and Pathology
  • Adipose Tissue and Metabolism
  • Diet, Metabolism, and Disease
  • Histone Deacetylase Inhibitors Research
  • Metal-Catalyzed Oxygenation Mechanisms

David Gius has contributed to a number of scientific papers published in various journals. Selected recent publications include:

  • "Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy," 2021, JNCI Journal of the National Cancer Institute
  • "Ketogenic diet induces p53-dependent cellular senescence in multiple organs," 2024, Science Advances
  • "SIRT3 Overexpression Ameliorates Asbestos-Induced Pulmonary Fibrosis, mt-DNA Damage, and Lung Fibrogenic Monocyte Recruitment," 2021, International Journal of Molecular Sciences
  • "An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth," 2020, Proceedings of the National Academy of Sciences
  • "Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease," 2024, Science Advances

The most frequent venues for their publications include:

  • Physiology (3 publications)
  • Hypertension (3 publications)
  • Science Advances (2 publications)
  • Free Radical Biology and Medicine (2 publications)
  • JNCI Journal of the National Cancer Institute (1 publication)

Among frequent collaborators, David Gius has published alongside:

  • Joseph Schell (9 collaborations)
  • Nobuo Horikoshi (7 collaborations)
  • E. Sandra Chocrón (6 collaborations)
  • Erin Munkácsy (6 collaborations)
  • Mahboubeh Varmazyad (5 collaborations)

Best Publications

  • Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

    Wenqiang Yu;David Gius;Patrick Onyango;Kristi Muldoon-Jacobs

  • Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

    Randa Tao;Mitchell C. Coleman;J. Daniel Pennington;Ozkan Ozden

  • SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

    Hyun Seok Kim;Krish Patel;Kristi Muldoon-Jacobs;Kheem S. Bisht

  • Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.

    Douglas R. Spitz;Edouard I. Azzam;Jian Jian Li;David Gius

  • Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

    Clara Bien Peek;Alison H. Affinati;Kathryn Moynihan Ramsey;Hsin-Yu Kuo;Hsin-Yu Kuo

  • SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

    Hyun Seok Kim;Athanassios Vassilopoulos;Rui Hong Wang;Tyler Lahusen

  • Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.

    Agnieszka A. Kendrick;Mahua Choudhury;Shaikh M. Rahman;Carrie E. McCurdy

  • Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

    Vinodkumar B. Pillai;Sadhana Samant;Nagalingam R. Sundaresan;Hariharasundaram Raghuraman

  • Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb

    Sergei A. Ezhevsky;Hikaru Nagahara;Adita M. Vocero-Akbani;David R. Gius

  • Ionizing radiation-induced oxidative stress alters miRNA expression.

    Nicole L. Simone;Benjamin P. Soule;David Ly;Anthony D. Saleh

  • Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death

    Rebecca L. Aft;F. W. Zhang;D. Gius

  • Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1

    David Gius;Ana Botero;Sunita Shah;Heather A. Curry

  • Oxidative stress, redox, and the tumor microenvironment.

    John A. Cook;David Gius;David A. Wink;Murali C. Krishna

  • Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

    Shuang Zhang;Samuel Weinberg;Matthew DeBerge;Anastasiia Gainullina

  • SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

    Kristi Muldoon Jacobs;J. Daniel Pennington;Kheem S. Bisht;Nukhet Aykin-Burns

  • Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements.

    David Gius;Xinmin Cao;Frank J. Rauscher;Donna R. Cohen

  • Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity

    Edward G. Mimnaugh;Wanping Xu;Michele Vos;Xitong Yuan

  • Geldanamycin and 17-Allylamino-17-demethoxygeldanamycin Potentiate the in Vitro and in Vivo Radiation Response of Cervical Tumor Cells via the Heat Shock Protein 90-Mediated Intracellular Signaling and Cytotoxicity

    Kheem S. Bisht;C. Matthew Bradbury;David Mattson;Aradhana Kaushal

  • Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.

    Wei Sj;Botero A;Hirota K;Bradbury Cm

  • Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis

    Seong Hoon Park;Ozkan Ozden;Haiyan Jiang;Yong I. Cha

Frequent Co-Authors

Douglas R. Spitz
Douglas R. Spitz University of Iowa
Chu-Xia Deng
Chu-Xia Deng University of Macau
Andrew P. Feinberg
Andrew P. Feinberg Johns Hopkins University
James B. Mitchell
James B. Mitchell National Institutes of Health
John C. Morris
John C. Morris Washington University in St. Louis
Michael N. Sack
Michael N. Sack National Institutes of Health
John A. Cook
John A. Cook National Institutes of Health
Jian Jian Li
Jian Jian Li University of California, Davis
Elise C. Kohn
Elise C. Kohn National Institutes of Health
Peter J. Munson
Peter J. Munson Center for Information Technology

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