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Biology and Biochemistry

D-Index
69
Citations
25489
World Ranking
7255
National Ranking
3330

Overview

Michael N. Sack is a researcher affiliated with the National Institutes of Health in the United States. Their work spans multiple disciplines primarily within Medicine and Biochemistry, Genetics and Molecular Biology. Sack's research focuses extensively on Molecular Biology, Physiology, and Immunology, with secondary interests in Epidemiology and Geriatrics and Gerontology.

The scientist's study topics include mitochondrial function and pathology, dietary effects on health, immune cell function and interaction, sirtuins and resveratrol in medicine, diet and metabolism studies, interferon and immune responses, and autophagy in disease and therapy.

Michael N. Sack has contributed to research published in several notable journals and venues. Frequent publication outlets include The Journal of Immunology, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Circulation Research, and iScience.

Key recent papers include:

  • Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (2024), published in Nature Communications
  • Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection (2021), published in Frontiers in Genetics
  • Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness (2021), published in Nature Metabolism
  • Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting (2024), published in Cell Reports
  • The emerging roles of GCN5L1 in mitochondrial and vacuolar organelle biology (2020), published in Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

They have collaborated extensively with other researchers, with frequent co-authors including Kaiyuan Wu, Komudi Singh, Rebecca D. Huffstutler, Shahin Hassanzadeh, and Kim Han. These collaborations reflect a network of expertise across molecular and cellular biology disciplines.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

    Ariel C. Bulua;Anna Simon;Ravikanth Maddipati;Martin Pelletier

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Fatty Acid Oxidation Enzyme Gene Expression Is Downregulated in the Failing Heart

    Michael N. Sack;Toni A. Rader;Sonhee Park;Jean Bastin

  • Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women

    M. N. Sack;D. J. Rader;R. O. Cannon

  • Myocardial Protection by Insulin at Reperfusion Requires Early Administration and Is Mediated via Akt and p70s6 Kinase Cell-Survival Signaling

    Anne K. Jonassen;Michael N. Sack;Ole D. Mjøs;Derek M. Yellon

  • Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

    Sruti Shiva;Michael N. Sack;James J. Greer;Mark Duranski

  • Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.

    Agnieszka A. Kendrick;Mahua Choudhury;Shaikh M. Rahman;Carrie E. McCurdy

  • Mitochondrial Function, Biology, and Role in Disease A Scientific Statement From the American Heart Association

    Elizabeth Murphy;Hossein Ardehali;Robert S. Balaban;Fabio DiLisa

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Identification of a Novel Role for Sphingolipid Signaling in TNF α and Ischemic Preconditioning Mediated Cardioprotection

    Sandrine Lecour;Robert M. Smith;Brian Woodward;Lionel H. Opie

  • Mitochondrial Metabolism, Sirtuins, and Aging

    Michael N. Sack;Toren Finkel

  • New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop.

    Lisa Schwartz Longacre;Robert A. Kloner;Robert A. Kloner;Andrew E. Arai;Christopher P. Baines

  • A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program

    Michael N. Sack;Dennis L. Disch;Howard A. Rockman;Daniel P. Kelly

  • Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance.

    Michael N Sack

  • Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1.

    Iain Scott;Bradley R. Webster;Jian H. Li;Michael N. Sack

  • Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia

    David M. Gilligan;Michael N. Sack;Victor Guetta;Philip R. Casino

  • Insulin Administered at Reoxygenation Exerts a Cardioprotective Effect in Myocytes by a Possible Anti-Apoptotic Mechanism

    Anne K Jonassen;Bhawanjit K Brar;Ole D Mjøs;Michael N Sack

  • Wnt signaling regulates hepatic metabolism.

    Hongjun Liu;Maria M. Fergusson;J. Julie Wu;Ilsa I. Rovira

  • Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection.

    J. Minners;E. J. Van Den Bos;D. M. Yellon;H. Schwalb

Frequent Co-Authors

Derek M. Yellon
Derek M. Yellon University College London
Elizabeth Murphy
Elizabeth Murphy National Heart Lung and Blood Institute
Lionel H. Opie
Lionel H. Opie University of Cape Town
Sruti Shiva
Sruti Shiva University of Pittsburgh
Toren Finkel
Toren Finkel University of Pittsburgh
Evelina Gatti
Evelina Gatti Aix-Marseille University
Charles Steenbergen
Charles Steenbergen Johns Hopkins University
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
Yee-Joo Tan
Yee-Joo Tan National University of Singapore
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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