D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 109 Citations 41,084 334 World Ranking 2566 National Ranking 109

Research.com Recognitions

Awards & Achievements

2007 - Fellow of the Royal Society of Canada Academy of Science

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Enzyme
  • Gene

Internal medicine, Endocrinology, Beta oxidation, Glycolysis and Fatty acid are his primary areas of study. Internal medicine is closely attributed to Pyruvate dehydrogenase complex in his research. His Endocrinology research incorporates themes from Biochemistry and Ischemia.

His Beta oxidation research includes elements of AMP-activated protein kinase and Acetyl-CoA carboxylase. Gary D. Lopaschuk combines subjects such as Oxidative phosphorylation, Cardioprotection and Citric acid cycle with his study of Glycolysis. The various areas that he examines in his Fatty acid study include Mitochondrion, Enzyme inhibitor and Triglyceride.

His most cited work include:

  • Myocardial Substrate Metabolism in the Normal and Failing Heart (1390 citations)
  • Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance (1369 citations)
  • Myocardial Fatty Acid Metabolism in Health and Disease (1204 citations)

What are the main themes of his work throughout his whole career to date?

Gary D. Lopaschuk spends much of his time researching Internal medicine, Endocrinology, Beta oxidation, Glycolysis and Biochemistry. The study incorporates disciplines such as Cardiology and Fatty acid in addition to Internal medicine. His Endocrinology study often links to related topics such as Cardiac function curve.

He interconnects AMP-activated protein kinase, Carnitine and Acetyl-CoA carboxylase in the investigation of issues within Beta oxidation. His biological study spans a wide range of topics, including Glycogen, Muscle hypertrophy, Lactate oxidation and Mitochondrion. His Heart failure research is multidisciplinary, incorporating elements of Heart disease and Obesity.

He most often published in these fields:

  • Internal medicine (74.95%)
  • Endocrinology (63.86%)
  • Beta oxidation (33.46%)

What were the highlights of his more recent work (between 2014-2021)?

  • Internal medicine (74.95%)
  • Endocrinology (63.86%)
  • Heart failure (14.53%)

In recent papers he was focusing on the following fields of study:

Gary D. Lopaschuk mainly investigates Internal medicine, Endocrinology, Heart failure, Beta oxidation and Cardiac function curve. His Internal medicine study frequently links to adjacent areas such as Cardiology. His Endocrinology study integrates concerns from other disciplines, such as Acetylation and Fatty acid.

His study in Heart failure is interdisciplinary in nature, drawing from both Diabetes mellitus, Obesity and Lipotoxicity. His Beta oxidation study combines topics from a wide range of disciplines, such as Insulin and Mitochondrion. His research investigates the connection with Cardiac function curve and areas like Myocardial infarction which intersect with concerns in Ischemia.

Between 2014 and 2021, his most popular works were:

  • Empagliflozin Increases Cardiac Energy Production in Diabetes: Novel Translational Insights Into the Heart Failure Benefits of SGLT2 Inhibitors. (120 citations)
  • Assessing Cardiac Metabolism (117 citations)
  • ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity (110 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Internal medicine
  • Gene

His primary areas of investigation include Internal medicine, Endocrinology, Heart failure, Beta oxidation and Glycolysis. His Internal medicine research is multidisciplinary, relying on both Amino acid and Cardiology. His Endocrinology study which covers Fatty acid that intersects with Sirtuin.

His research integrates issues of Endoplasmic reticulum, Heart disease and Ischemia in his study of Heart failure. The Beta oxidation study combines topics in areas such as Diabetes mellitus and Stem cell. His work investigates the relationship between Glycolysis and topics such as Pressure overload that intersect with problems in Cardiac efficiency and Pulmonary hypertension.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Myocardial Substrate Metabolism in the Normal and Failing Heart

William C. Stanley;Fabio A. Recchia;Gary D. Lopaschuk.
Physiological Reviews (2005)

1984 Citations

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

Timothy R. Koves;John R. Ussher;Robert C. Noland;Dorothy Slentz.
Cell Metabolism (2008)

1705 Citations

Myocardial Fatty Acid Metabolism in Health and Disease

Gary D. Lopaschuk;John R. Ussher;Clifford D. L. Folmes;Jagdip S. Jaswal.
Physiological Reviews (2010)

1667 Citations

A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

Sébastien Bonnet;Stephen L. Archer;Joan Allalunis-Turner;Alois Haromy.
Cancer Cell (2007)

1628 Citations

The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus

Brian N. Finck;John J. Lehman;Teresa C. Leone;Michael J. Welch.
Journal of Clinical Investigation (2002)

1026 Citations

The Antianginal Drug Trimetazidine Shifts Cardiac Energy Metabolism From Fatty Acid Oxidation to Glucose Oxidation by Inhibiting Mitochondrial Long-Chain 3-Ketoacyl Coenzyme A Thiolase

Paul F. Kantor;Arnaud Lucien;Raymond Kozak;Gary D. Lopaschuk.
Circulation Research (2000)

962 Citations

Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions.

William C. Stanley;Gary D. Lopaschuk;Jennifer L. Hall;James G. McCormack.
Cardiovascular Research (1997)

880 Citations

High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5′-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase

Naomi Kudo;Amy J. Barr;Rick L. Barr;Snehal Desai.
Journal of Biological Chemistry (1995)

830 Citations

Regulation of fatty acid oxidation in the mammalian heart in health and disease.

G D Lopaschuk;D D Belke;J Gamble;T Itoi.
Biochimica et Biophysica Acta (1994)

736 Citations

Cardiovascular remodelling in coronary artery disease and heart failure

Gerd Heusch;Peter Libby;Bernard Gersh;Derek Yellon.
The Lancet (2014)

592 Citations

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