2007 - Fellow of the Royal Society of Canada Academy of Science
Internal medicine, Endocrinology, Beta oxidation, Glycolysis and Fatty acid are his primary areas of study. Internal medicine is closely attributed to Pyruvate dehydrogenase complex in his research. His Endocrinology research incorporates themes from Biochemistry and Ischemia.
His Beta oxidation research includes elements of AMP-activated protein kinase and Acetyl-CoA carboxylase. Gary D. Lopaschuk combines subjects such as Oxidative phosphorylation, Cardioprotection and Citric acid cycle with his study of Glycolysis. The various areas that he examines in his Fatty acid study include Mitochondrion, Enzyme inhibitor and Triglyceride.
Gary D. Lopaschuk spends much of his time researching Internal medicine, Endocrinology, Beta oxidation, Glycolysis and Biochemistry. The study incorporates disciplines such as Cardiology and Fatty acid in addition to Internal medicine. His Endocrinology study often links to related topics such as Cardiac function curve.
He interconnects AMP-activated protein kinase, Carnitine and Acetyl-CoA carboxylase in the investigation of issues within Beta oxidation. His biological study spans a wide range of topics, including Glycogen, Muscle hypertrophy, Lactate oxidation and Mitochondrion. His Heart failure research is multidisciplinary, incorporating elements of Heart disease and Obesity.
Gary D. Lopaschuk mainly investigates Internal medicine, Endocrinology, Heart failure, Beta oxidation and Cardiac function curve. His Internal medicine study frequently links to adjacent areas such as Cardiology. His Endocrinology study integrates concerns from other disciplines, such as Acetylation and Fatty acid.
His study in Heart failure is interdisciplinary in nature, drawing from both Diabetes mellitus, Obesity and Lipotoxicity. His Beta oxidation study combines topics from a wide range of disciplines, such as Insulin and Mitochondrion. His research investigates the connection with Cardiac function curve and areas like Myocardial infarction which intersect with concerns in Ischemia.
His primary areas of investigation include Internal medicine, Endocrinology, Heart failure, Beta oxidation and Glycolysis. His Internal medicine research is multidisciplinary, relying on both Amino acid and Cardiology. His Endocrinology study which covers Fatty acid that intersects with Sirtuin.
His research integrates issues of Endoplasmic reticulum, Heart disease and Ischemia in his study of Heart failure. The Beta oxidation study combines topics in areas such as Diabetes mellitus and Stem cell. His work investigates the relationship between Glycolysis and topics such as Pressure overload that intersect with problems in Cardiac efficiency and Pulmonary hypertension.
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Myocardial Substrate Metabolism in the Normal and Failing Heart
William C. Stanley;Fabio A. Recchia;Gary D. Lopaschuk.
Physiological Reviews (2005)
Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance
Timothy R. Koves;John R. Ussher;Robert C. Noland;Dorothy Slentz.
Cell Metabolism (2008)
Myocardial Fatty Acid Metabolism in Health and Disease
Gary D. Lopaschuk;John R. Ussher;Clifford D. L. Folmes;Jagdip S. Jaswal.
Physiological Reviews (2010)
A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
Sébastien Bonnet;Stephen L. Archer;Joan Allalunis-Turner;Alois Haromy.
Cancer Cell (2007)
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Brian N. Finck;John J. Lehman;Teresa C. Leone;Michael J. Welch.
Journal of Clinical Investigation (2002)
The Antianginal Drug Trimetazidine Shifts Cardiac Energy Metabolism From Fatty Acid Oxidation to Glucose Oxidation by Inhibiting Mitochondrial Long-Chain 3-Ketoacyl Coenzyme A Thiolase
Paul F. Kantor;Arnaud Lucien;Raymond Kozak;Gary D. Lopaschuk.
Circulation Research (2000)
Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions.
William C. Stanley;Gary D. Lopaschuk;Jennifer L. Hall;James G. McCormack.
Cardiovascular Research (1997)
High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5′-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase
Naomi Kudo;Amy J. Barr;Rick L. Barr;Snehal Desai.
Journal of Biological Chemistry (1995)
Regulation of fatty acid oxidation in the mammalian heart in health and disease.
G D Lopaschuk;D D Belke;J Gamble;T Itoi.
Biochimica et Biophysica Acta (1994)
Cardiovascular remodelling in coronary artery disease and heart failure
Gerd Heusch;Peter Libby;Bernard Gersh;Derek Yellon.
The Lancet (2014)
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