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Deborah M. Muoio

Deborah M. Muoio

D-Index & Metrics

Medicine

D-Index
76
Citations
25019
World Ranking
18678
National Ranking
9306

Overview

Deborah M. Muoio is affiliated with Duke University in the United States and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work spans several interconnected fields, including physiology, molecular biology, epidemiology, biochemistry, and cardiology and cardiovascular medicine.

The scientist's research primarily addresses topics related to adipose tissue and metabolism, diet and metabolism studies, mitochondrial function and pathology, lipid metabolism and biosynthesis, metabolomics and mass spectrometry studies, liver disease diagnosis and treatment, and cardiovascular function and risk factors.

Frequent co-authors of Deborah M. Muoio include:

  • Timothy R. Koves
  • Olga Ilkayeva
  • Paul A. Grimsrud
  • Ashley S. Williams
  • Scott B. Crown

Publication venues where they have appeared multiple times include:

  • UNC Libraries
  • Cell Metabolism
  • Cell Reports
  • Journal of Clinical Investigation
  • JCI Insight

Highlighted recent research papers are:

  • Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury (2020, Cell Metabolism)
  • Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice (2020, Nature Metabolism)
  • Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure (2020, Circulation Research)
  • Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion (2020, Cell Reports)
  • Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis (2022, Cell Reports)

Best Publications

  • Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

    Timothy R. Koves;John R. Ussher;Robert C. Noland;Dorothy Slentz

  • Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes.

    Deborah M. Muoio;Christopher B. Newgard

  • Energy metabolism in uncoupling protein 3 gene knockout mice.

    Antonio J. Vidal-Puig;Danica Grujic;Chen-Yu Zhang;Thilo Hagen

  • The Failing Heart Relies on Ketone Bodies as a Fuel

    Gregory Aubert;Ola J. Martin;Julie L. Horton;Ling Lai

  • Leptin Directly Alters Lipid Partitioning in Skeletal Muscle

    Deborah M Muoio;G Lynis Dohn;Frederick T Fiedorek;Edward B Tapscott

  • Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues

    Jiang Zhu;Mazhar Adli;James Y. Zou;Griet Verstappen;Griet Verstappen

  • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.

    Deborah M. Muoio;Paul S. MacLean;David B. Lang;Shi Li

  • AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target.

    Deborah M. Muoio;Kimberly Seefeld;Lee A. Witters;Rosalind A. Coleman

  • Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

    Jie An;Deborah M Muoio;Masakazu Shiota;Yuka Fujimoto

  • SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

    Gaëlle Laurent;Natalie J. German;Asish K. Saha;Vincent C.J. de Boer

  • Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

    P. Darrell Neufer;Marcas M. Bamman;Deborah Marie Muoio;Claude Bouchard

  • Obesity-Related Derangements in Metabolic Regulation

    Deborah M Muoio;Christopher B Newgard

  • Peroxisome proliferator-activated receptor-γ co-activator 1α-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency

    Timothy R. Koves;Ping Li;Jie An;Takayuki Akimoto

  • Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans.

    Matthew W. Hulver;Jason R. Berggren;Michael J. Carper;Makoto Miyazaki

  • Physiological and nutritional regulation of enzymes of triacylglycerol synthesis.

    Rosalind A. Coleman;Tal M. Lewin;Deborah M. Muoio

  • Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock

    Deborah M. Muoio

  • Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

    John R. Ussher;Timothy R. Koves;Virgilio J.J. Cadete;Liyan Zhang

  • Carnitine Insufficiency Caused by Aging and Overnutrition Compromises Mitochondrial Performance and Metabolic Control

    Robert C. Noland;Timothy R. Koves;Sarah E. Seiler;Helen Lum

  • Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

    Deborah M. Muoio;Robert C. Noland;Jean Paul Kovalik;Sarah E. Seiler

  • Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle

    Deborah M. Muoio;P. Darrell Neufer

Frequent Co-Authors

Olga Ilkayeva
Olga Ilkayeva Duke University
Christopher B. Newgard
Christopher B. Newgard Duke University
Rosalind A. Coleman
Rosalind A. Coleman University of North Carolina at Chapel Hill
G. Lynis Dohm
G. Lynis Dohm East Carolina University
William E. Kraus
William E. Kraus Duke University
Daniel P. Kelly
Daniel P. Kelly University of Pennsylvania
Joseph A. Houmard
Joseph A. Houmard East Carolina University
Jason R.B. Dyck
Jason R.B. Dyck University of Alberta
Gary W. Cline
Gary W. Cline Yale University
P. Darrell Neufer
P. Darrell Neufer East Carolina University

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