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Gerald I. Shulman

Gerald I. Shulman

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Best Scientists
2025
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Medicine
USA
2026

D-Index & Metrics

Best Scientists

D-Index
198
Citations
162477
World Ranking
315
National Ranking
211

Medicine

D-Index
203
Citations
171736
World Ranking
161
National Ranking
108

Research.com Recognitions

  • 2026 - Research.com Medicine in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2023 - Research.com Medicine in United States Leader Award
  • 2018 - Fellow of the American Academy of Arts and Sciences
  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2007 - Member of the National Academy of Sciences
  • 2005 - Member of the National Academy of Medicine (NAM)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Gerald I. Shulman is affiliated with Yale University in the United States and has made substantial contributions across multiple fields related to medicine and biochemistry. Their research spans a diverse range of topics with a strong focus on metabolism, liver diseases, and diabetes.

The primary fields of study for this scientist include Medicine and Biochemistry, Genetics and Molecular Biology. Within these domains, their work notably covers key subfields such as Molecular Biology, Physiology, Epidemiology, Endocrinology, Diabetes and Metabolism, and Surgery.

The scientist's principal topics of investigation include:

  • Adipose Tissue and Metabolism
  • Liver Disease Diagnosis and Treatment
  • Metabolism, Diabetes, and Cancer
  • Diet and metabolism studies
  • Diet, Metabolism, and Disease
  • Pancreatic function and diabetes
  • Lipid metabolism and biosynthesis

Gerald I. Shulman has published extensively in several scientific venues, with frequent publications in:

  • Diabetes
  • Journal of Diabetes
  • Proceedings of the National Academy of Sciences
  • Cell Metabolism
  • bioRxiv (Cold Spring Harbor Laboratory)

The scientist has collaborated frequently with colleagues including Kitt Falk Petersen, Ali Nasiri, Mario Kahn, Rachel J. Perry, and Rafael Calais Gaspar.

Recent representative papers include:

  • "Mechanisms and disease consequences of nonalcoholic fatty liver disease" (2021), published in Cell
  • "Cellular and Molecular Mechanisms of Metformin Action" (2020), published in Endocrine Reviews
  • "Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging" (2020), published in Frontiers in Physiology
  • "Regulation of adipose tissue inflammation by interleukin 6" (2020), published in Proceedings of the National Academy of Sciences
  • "Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease" (2020), published in Proceedings of the National Academy of Sciences

The professional recognition of Gerald I. Shulman includes election to several scientific organizations such as the National Academy of Sciences, National Academy of Medicine, and the American Association for the Advancement of Science (AAAS). They were named a Fellow of the American Academy of Arts and Sciences in 2018 and have membership in the Association of American Physicians.

Best Publications

  • Cellular mechanisms of insulin resistance

    Gerald I. Shulman

  • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

    Jorge Alejandro Henao-Mejía;Eran Elinav;Cheng Cheng Jin;Liming Hao

  • Mitochondrial dysfunction and type 2 diabetes.

    Bradford B. Lowell;Gerald I. Shulman

  • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.

    Kitt Falk Petersen;Sylvie Dufour;Douglas Befroy;Rina Garcia

  • Mitochondrial dysfunction in the elderly: possible role in insulin resistance

    Kitt Falk Petersen;Douglas Befroy;Sylvie Dufour;James Dziura

  • Mechanisms for insulin resistance: common threads and missing links.

    Varman T. Samuel;Gerald I. Shulman

  • Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

    Han Cho;James Mu;Jason K. Kim;Jason K. Kim;Joanne L. Thorvaldsen

  • Mechanisms of Insulin Action and Insulin Resistance

    Max C. Petersen;Gerald I. Shulman

  • Disruption of IRS-2 causes type 2 diabetes in mice

    Dominic J. Withers;Julio Sanchez Gutierrez;Heather Towery;Deborah J. Burks

  • Mechanism of free fatty acid-induced insulin resistance in humans.

    Michael Roden;Thomas B. Price;Gianluca Perseghin;Kitt Falk Petersen

  • Type 2 diabetes mellitus.

    Ralph A. DeFronzo;Ele Ferrannini;Leif Groop;Robert R. Henry

  • Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle *

    Chunli Yu;Yan Chen;Gary W. Cline;Dongyan Zhang

  • Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

    G. Boden;G. I. Shulman

  • Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

    Alan Dresner;Didier Laurent;Melissa Marcucci;Margaret E. Griffin

  • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

    Margaret E. Griffin;Melissa J. Marcucci;Gary W. Cline;Kim Bell

  • Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease

    Varman T. Samuel;Zhen Xiang Liu;Xianqin Qu;Benjamin D. Elder

  • Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

    E Dale Abel;Odile Peroni;Jason K. Kim;Young Bum Kim

  • Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

    Krssak M;Falk Petersen K;Dresner A;DiPietro L

  • Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by 13C Nuclear Magnetic Resonance Spectroscopy

    Gerald I. Shulman;Douglas L. Rothman;Thomas Jue;Peter Stein

  • Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

    M.Dodson Michael;Rohit N. Kulkarni;Catherine Postic;Steven F. Previs

Frequent Co-Authors

Gary W. Cline
Gary W. Cline Yale University
Kitt Falk Petersen
Kitt Falk Petersen Yale University
Douglas L. Rothman
Douglas L. Rothman Yale University
Jason K. Kim
Jason K. Kim University of Massachusetts Chan Medical School
Robert G. Shulman
Robert G. Shulman Yale University
Michael Roden
Michael Roden Heinrich Heine University Düsseldorf
Graeme F. Mason
Graeme F. Mason Yale University
Sonia Caprio
Sonia Caprio Yale University
Ira J. Goldberg
Ira J. Goldberg New York University
Robert S. Sherwin
Robert S. Sherwin Yale University

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