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Christopher B. Newgard

Christopher B. Newgard

D-Index & Metrics

Medicine

D-Index
137
Citations
78299
World Ranking
1897
National Ranking
1076

Overview

Christopher B. Newgard is affiliated with Duke University in the United States and has an extensive research portfolio primarily focused on medicine and biochemistry, genetics, and molecular biology. Their work intersects several subfields, including physiology, molecular biology, endocrinology, diabetes and metabolism, surgery, and epidemiology.

The scientist's research topics encompass various areas related to metabolism and disease. Key topics include:

  • Diet and metabolism studies
  • Adipose tissue and metabolism
  • Metabolomics and mass spectrometry studies
  • Liver disease diagnosis and treatment
  • Diet, metabolism, and disease
  • Pancreatic function and diabetes
  • Cholesterol and lipid metabolism

Christopher B. Newgard has contributed to numerous research articles, with several recent publications as examples:

  • "Mechanisms controlling pancreatic islet cell function in insulin secretion," 2021, Nature Reviews Molecular Cell Biology
  • "Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street," 2021, Molecular Metabolism
  • "Temporal dynamics of the multi-omic response to endurance exercise training," 2024, Nature
  • "Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion," 2020, Cell Metabolism
  • "Effects of Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in Subjects With Type 2 Diabetes," 2021, The Journal of Clinical Endocrinology & Metabolism

Frequent publication venues for the scientist's work include:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Diabetes
  • Journal of Clinical Investigation
  • The Journal of Clinical Endocrinology & Metabolism

Collaborations with other researchers form a significant part of the scientist's work. Frequent co-authors include:

  • Olga Ilkayeva
  • Michael J. Muehlbauer
  • Svati H. Shah
  • James R. Bain
  • Lydia Coulter Kwee

Best Publications

  • Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

    Vanessa K. Ridaura;Jeremiah J. Faith;Federico E. Rey;Jiye Cheng

  • A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

    Christopher B. Newgard;Jie An;James R. Bain;Michael J. Muehlbauer

  • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.

    J. Cliff Yoon;Pere Puigserver;Guoxun Chen;Jerry Donovan

  • Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

    Timothy R. Koves;John R. Ussher;Robert C. Noland;Dorothy Slentz

  • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

    Matthew D. Hirschey;Tadahiro Shimazu;Tadahiro Shimazu;Eric Goetzman;Enxuan Jing

  • Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes.

    Deborah M. Muoio;Christopher B. Newgard

  • Interplay between lipids and branched-chain amino acids in development of insulin resistance.

    Christopher B. Newgard

  • Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

    Hans E. Hohmeier;Hindrik Mulder;Guoxun Chen;Rosemarie Henkel-Rieger

  • Use of recombinant adenovirus for metabolic engineering of mammalian cells.

    Thomas C. Becker;Richard J. Noel;Ward S. Coats;Anna M. Gómez-Foix

  • DIRECT ANTIDIABETIC EFFECT OF LEPTIN THROUGH TRIGLYCERIDE DEPLETION OF TISSUES

    Michio Shimabukuro;Kazunori Koyama;Guoxun Chen;May-Yun Wang

  • SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.

    Matthew D. Hirschey;Tadahiro Shimazu;Enxuan Jing;Carrie A. Grueter

  • Metabolic coupling factors in pancreatic beta-cell signal transduction.

    C B Newgard;J D McGarry

  • Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP

    Jiandie Lin;Ruojing Yang;Paul T. Tarr;Pei Hsuan Wu

  • Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

    Valerie A. Gerriets;Rigel J. Kishton;Amanda G. Nichols;Andrew N. Macintyre

  • Metabolomics and Metabolic Diseases: Where Do We Stand?

    Christopher B. Newgard

  • Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children

    Laura V. Blanton;Mark R. Charbonneau;Tarek Salih;Michael J. Barratt

  • Cafeteria Diet Is a Robust Model of Human Metabolic Syndrome With Liver and Adipose Inflammation: Comparison to High-Fat Diet

    Brante P. Sampey;Amanda M. Vanhoose;Helena M. Winfield;Alex J. Freemerman

  • Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells

    Julie St-Pierre;Jiandie Lin;Stefan Krauss;Paul T. Tarr

  • The Impact of a Consortium of Fermented Milk Strains on the Gut Microbiome of Gnotobiotic Mice and Monozygotic Twins

    Nathan P. McNulty;Tanya Yatsunenko;Ansel Hsiao;Jeremiah J. Faith

  • SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

    Matthew J. Rardin;Wenjuan He;Yuya Nishida;John C. Newman

Frequent Co-Authors

Olga Ilkayeva
Olga Ilkayeva Duke University
Svati H. Shah
Svati H. Shah Duke University
William E. Kraus
William E. Kraus Duke University
Roger H Unger
Roger H Unger The University of Texas Southwestern Medical Center
Deborah M. Muoio
Deborah M. Muoio Duke University
Shawn C. Burgess
Shawn C. Burgess The University of Texas Southwestern Medical Center
Elizabeth R. Hauser
Elizabeth R. Hauser Duke University
Laura P. Svetkey
Laura P. Svetkey Duke University
L. Kristin Newby
L. Kristin Newby Duke University
Christopher B. Granger
Christopher B. Granger Duke University

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