World's Best Scientists 2026 revealed!
Bruce M. Spiegelman

Bruce M. Spiegelman

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Best Scientists
2025
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Biology and Biochemistry
USA
2026

D-Index & Metrics

Best Scientists

D-Index
200
Citations
231087
World Ranking
289
National Ranking
190

Biology and Biochemistry

D-Index
202
Citations
240884
World Ranking
31
National Ranking
26

Bruce M. Spiegelman publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Bruce M. Spiegelman sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 495 publications — 95th percentile

95% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Bruce M. Spiegelman D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Bruce M. Spiegelman sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 202 D-Index — 100th percentile

100% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2014 - Member of the National Academy of Medicine (NAM)
  • 2002 - Member of the National Academy of Sciences
  • 2002 - Fellow of the American Academy of Arts and Sciences

Overview

Bruce M. Spiegelman is affiliated with Harvard University in the United States and has contributed extensively to research in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work covers several subfields, including Physiology, Molecular Biology, Cell Biology, Immunology, and Rehabilitation.

Their research primarily focuses on topics related to Adipose Tissue and Metabolism, Mitochondrial Function and Pathology, Muscle Metabolism and Nutrition, Exercise and Physiological Responses, Muscle Physiology and Disorders, Metabolomics and Mass Spectrometry Studies, and Adipokines, Inflammation, and Metabolic Diseases.

Notable recent publications include:

  • Exercise hormone irisin is a critical regulator of cognitive function, 2021, Nature Metabolism
  • CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling, 2020, Cell
  • Creatine kinase B controls futile creatine cycling in thermogenic fat, 2021, Nature
  • γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis, 2020, Nature
  • Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism, 2020, Nature Metabolism

Frequent co-authors who have collaborated on multiple publications with Spiegelman include:

  • Phillip A. Dumesic
  • Mark P. Jedrychowski
  • Steven P. Gygi
  • Melanie J. Mittenbühler
  • Hyeonwoo Kim

Their work has appeared repeatedly in prominent scientific journals, with a record of publications in venues such as:

  • Cell Metabolism (8 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (8 publications)
  • Nature Metabolism (6 publications)
  • Nature (4 publications)
  • eLife (4 publications)

Bruce M. Spiegelman has been recognized with membership in several prestigious organizations, including being named a Member of the National Academy of Medicine in 2014, a Fellow of the American Academy of Arts and Sciences in 2002, and a Member of the National Academy of Sciences since 2002.

Best Publications

  • PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

    Vamsi K Mootha;Cecilia M Lindgren;Cecilia M Lindgren;Karl-Fredrik Eriksson;Aravind Subramanian

  • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

    Gökhan S. Hotamisligil;Narinder S. Shargill;Bruce M. Spiegelman

  • A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

    Pontus Boström;Jun Wu;Mark P. Jedrychowski;Anisha Korde

  • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

    G S Hotamisligil;P Arner;J F Caro;R L Atkinson

  • Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

    Zhidan Wu;Pere Puigserver;Ulf Andersson;Chenyu Zhang

  • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.

    Pere Puigserver;Zhidan Wu;Cheol Won Park;Reed Graves

  • 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.

    Barry M. Forman;Barry M. Forman;Peter Tontonoz;Jasmine Chen;Regina P. Brun

  • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.

    Peter Tontonoz;Erding Hu;Bruce M. Spiegelman

  • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

    Joseph T. Rodgers;Carlos Lerin;Wilhelm Haas;Steven P. Gygi

  • Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

    Jun Wu;Pontus Boström;Lauren M. Sparks;Li Ye

  • IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

    Gökhan S. Hotamisligil;Pascal Peraldi;Adriane Budavari;Ramsey Ellis

  • Obesity and the Regulation of Energy Balance

    Bruce M. Spiegelman;Jeffrey S. Flier

  • AdipoQ is a novel adipose-specific gene dysregulated in obesity.

    Erding Hu;Peng Liang;Bruce M. Spiegelman

  • Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.

    Pere Puigserver;Bruce M. Spiegelman

  • Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

    Jiandie Lin;Hai Wu;Paul T. Tarr;Chen Yu Zhang

  • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

    Sibylle Jäger;Christoph Handschin;Julie St-Pierre;Bruce M Spiegelman

  • Fat and beyond: the diverse biology of PPARgamma.

    Peter Tontonoz;Bruce M Spiegelman

  • Adipocytes as regulators of energy balance and glucose homeostasis

    Evan D. Rosen;Bruce M. Spiegelman

  • PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

    Evan D Rosen;Pasha Sarraf;Amy E Troy;Gary Bradwin

  • Metabolic control through the PGC-1 family of transcription coactivators.

    Jiandie D. Lin;Christoph Handschin;Bruce M Spiegelman

Frequent Co-Authors

Pere Puigserver
Pere Puigserver Harvard University
Evan D. Rosen
Evan D. Rosen Beth Israel Deaconess Medical Center
Mark P. Jedrychowski
Mark P. Jedrychowski Harvard University
Jiandie D. Lin
Jiandie D. Lin University of Michigan–Ann Arbor
Peter Tontonoz
Peter Tontonoz University of California, Los Angeles
Shingo Kajimura
Shingo Kajimura Beth Israel Deaconess Medical Center
Jeffrey S. Flier
Jeffrey S. Flier Harvard University
Christoph Handschin
Christoph Handschin University of Basel
Paul Cohen
Paul Cohen Rockefeller University
Bradford B. Lowell
Bradford B. Lowell Beth Israel Deaconess Medical Center

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Each of these pathways offers unique advantages and aligns well with a strong foundation in Biology or Biochemistry.

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