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Bruce M. Spiegelman

Bruce M. Spiegelman

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Best Scientists
2025
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Biology and Biochemistry
USA
2026

D-Index & Metrics

Best Scientists

D-Index
200
Citations
231087
World Ranking
289
National Ranking
190

Biology and Biochemistry

D-Index
202
Citations
240884
World Ranking
31
National Ranking
26

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2014 - Member of the National Academy of Medicine (NAM)
  • 2002 - Member of the National Academy of Sciences
  • 2002 - Fellow of the American Academy of Arts and Sciences

Overview

Bruce M. Spiegelman is affiliated with Harvard University in the United States and has contributed extensively to research in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work covers several subfields, including Physiology, Molecular Biology, Cell Biology, Immunology, and Rehabilitation.

Their research primarily focuses on topics related to Adipose Tissue and Metabolism, Mitochondrial Function and Pathology, Muscle Metabolism and Nutrition, Exercise and Physiological Responses, Muscle Physiology and Disorders, Metabolomics and Mass Spectrometry Studies, and Adipokines, Inflammation, and Metabolic Diseases.

Notable recent publications include:

  • Exercise hormone irisin is a critical regulator of cognitive function, 2021, Nature Metabolism
  • CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling, 2020, Cell
  • Creatine kinase B controls futile creatine cycling in thermogenic fat, 2021, Nature
  • γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis, 2020, Nature
  • Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism, 2020, Nature Metabolism

Frequent co-authors who have collaborated on multiple publications with Spiegelman include:

  • Phillip A. Dumesic
  • Mark P. Jedrychowski
  • Steven P. Gygi
  • Melanie J. Mittenbühler
  • Hyeonwoo Kim

Their work has appeared repeatedly in prominent scientific journals, with a record of publications in venues such as:

  • Cell Metabolism (8 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (8 publications)
  • Nature Metabolism (6 publications)
  • Nature (4 publications)
  • eLife (4 publications)

Bruce M. Spiegelman has been recognized with membership in several prestigious organizations, including being named a Member of the National Academy of Medicine in 2014, a Fellow of the American Academy of Arts and Sciences in 2002, and a Member of the National Academy of Sciences since 2002.

Best Publications

  • PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

    Vamsi K Mootha;Cecilia M Lindgren;Cecilia M Lindgren;Karl-Fredrik Eriksson;Aravind Subramanian

  • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

    Gökhan S. Hotamisligil;Narinder S. Shargill;Bruce M. Spiegelman

  • A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

    Pontus Boström;Jun Wu;Mark P. Jedrychowski;Anisha Korde

  • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

    G S Hotamisligil;P Arner;J F Caro;R L Atkinson

  • Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

    Zhidan Wu;Pere Puigserver;Ulf Andersson;Chenyu Zhang

  • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.

    Pere Puigserver;Zhidan Wu;Cheol Won Park;Reed Graves

  • 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.

    Barry M. Forman;Barry M. Forman;Peter Tontonoz;Jasmine Chen;Regina P. Brun

  • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.

    Peter Tontonoz;Erding Hu;Bruce M. Spiegelman

  • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

    Joseph T. Rodgers;Carlos Lerin;Wilhelm Haas;Steven P. Gygi

  • Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

    Jun Wu;Pontus Boström;Lauren M. Sparks;Li Ye

  • IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

    Gökhan S. Hotamisligil;Pascal Peraldi;Adriane Budavari;Ramsey Ellis

  • Obesity and the Regulation of Energy Balance

    Bruce M. Spiegelman;Jeffrey S. Flier

  • AdipoQ is a novel adipose-specific gene dysregulated in obesity.

    Erding Hu;Peng Liang;Bruce M. Spiegelman

  • Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.

    Pere Puigserver;Bruce M. Spiegelman

  • Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

    Jiandie Lin;Hai Wu;Paul T. Tarr;Chen Yu Zhang

  • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

    Sibylle Jäger;Christoph Handschin;Julie St-Pierre;Bruce M Spiegelman

  • Fat and beyond: the diverse biology of PPARgamma.

    Peter Tontonoz;Bruce M Spiegelman

  • Adipocytes as regulators of energy balance and glucose homeostasis

    Evan D. Rosen;Bruce M. Spiegelman

  • PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

    Evan D Rosen;Pasha Sarraf;Amy E Troy;Gary Bradwin

  • Metabolic control through the PGC-1 family of transcription coactivators.

    Jiandie D. Lin;Christoph Handschin;Bruce M Spiegelman

Frequent Co-Authors

Pere Puigserver
Pere Puigserver Harvard University
Evan D. Rosen
Evan D. Rosen Beth Israel Deaconess Medical Center
Mark P. Jedrychowski
Mark P. Jedrychowski Harvard University
Jiandie D. Lin
Jiandie D. Lin University of Michigan–Ann Arbor
Peter Tontonoz
Peter Tontonoz University of California, Los Angeles
Shingo Kajimura
Shingo Kajimura Beth Israel Deaconess Medical Center
Jeffrey S. Flier
Jeffrey S. Flier Harvard University
Christoph Handschin
Christoph Handschin University of Basel
Paul Cohen
Paul Cohen Rockefeller University
Bradford B. Lowell
Bradford B. Lowell Beth Israel Deaconess Medical Center

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