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Christoph Handschin

Christoph Handschin

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
26849
World Ranking
11670
National Ranking
209

Overview

Christoph Handschin is affiliated with the University of Basel in Switzerland and has an extensive research background primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work encompasses molecular biology, physiology, aging, rehabilitation, and genetics, reflecting a broad focus within the life sciences.

The scientist's research covers several main topics, including adipose tissue and metabolism, muscle physiology and disorders, genetics, aging, and longevity in model organisms, exercise and physiological responses, mitochondrial function and pathology, circadian rhythm and melatonin, and genetics and physical performance.

Christoph Handschin has published numerous papers in reputable venues. Some recent publications include:

  • The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia, 2020, published in Nature Communications
  • The molecular athlete: exercise physiology from mechanisms to medals, 2023, published in Physiological Reviews
  • Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle, 2022, published in Nature Communications
  • The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations, 2021, published in Frontiers in Physiology
  • Molecular control of endurance training adaptation in male mouse skeletal muscle, 2023, published in Nature Metabolism

Frequent publication venues for Handschin include bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, The Journal of Physiology, Molecular Metabolism, and Physiological Reviews. These venues reflect a focus on both molecular and physiological aspects of biomedical research.

The scientist has collaborated frequently with several co-authors, notably Regula Furrer, Danilo Ritz, Julien Delezie, Aurel B. Leuchtmann, and Bettina Karrer-Cardel, indicating a collaborative research environment.

Best Publications

  • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

    Sibylle Jäger;Christoph Handschin;Julie St-Pierre;Bruce M Spiegelman

  • Metabolic control through the PGC-1 family of transcription coactivators.

    Jiandie D. Lin;Christoph Handschin;Bruce M Spiegelman

  • Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

    Julie St-Pierre;Stavit Drori;Marc Uldry;Jessica M. Silvaggi

  • The role of exercise and PGC1α in inflammation and chronic disease

    Christoph Handschin;Bruce M. Spiegelman

  • Peroxisome Proliferator-Activated Receptor γ Coactivator 1 Coactivators, Energy Homeostasis, and Metabolism

    Christophe Handschin;Bruce M Spiegelman

  • PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

    Marco Sandri;Jiandie Lin;Christoph Handschin;Wenli Yang

  • An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle

    Christoph Handschin;James Rhee;Jiandie Lin;Paul T. Tarr

  • Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

    Vamsi K. Mootha;Christoph Handschin;Dan Arlow;Xiaohui Xie

  • Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle

    Zoltan Arany;Huamei He;Jiandie Lin;Kirsten Hoyer

  • Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP

    Jiandie Lin;Ruojing Yang;Paul T. Tarr;Pei Hsuan Wu

  • Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals

    Christoph Handschin;Sherry Chin;Ping Li;Fenfen Liu

  • Induction of Drug Metabolism: The Role of Nuclear Receptors

    Christoph Handschin;Urs A. Meyer

  • Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

    Svenia Schnyder;Christoph Handschin

  • Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α

    Christoph Handschin;Jiandie Lin;James Rhee;Anne Kathrin Peyer

  • Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk

    Christoph Handschin;Cheol Soo Choi;Sherry Chin;Sheene Kim

  • PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy

    Christoph Handschin;Yvonne M. Kobayashi;Sherry Chin;Patrick Seale

  • Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK

    Melina Fan;James Rhee;Julie St-Pierre;Christoph Handschin

  • Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells

    Zhidan Wu;Xueming Huang;Yajun Feng;Christoph Handschin

  • Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

    Cheol Soo Choi;Douglas E. Befroy;Roberto Codella;Sheene Kim

  • Endocrine Crosstalk Between Skeletal Muscle and the Brain.

    Julien Delezie;Christoph Handschin

Frequent Co-Authors

Bruce M. Spiegelman
Bruce M. Spiegelman Harvard University
Jiandie D. Lin
Jiandie D. Lin University of Michigan–Ann Arbor
Francesco Zorzato
Francesco Zorzato University of Ferrara
Erik van Nimwegen
Erik van Nimwegen University of Basel
Alexander Schmidt
Alexander Schmidt University of Basel
Julie St-Pierre
Julie St-Pierre McGill University
Markus A. Rüegg
Markus A. Rüegg University of Basel
Susan Treves
Susan Treves University Hospital of Basel
Vamsi K. Mootha
Vamsi K. Mootha Harvard Medical School
Christoph Hess
Christoph Hess University of Cambridge

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