Francesco Zorzato focuses on Ryanodine receptor, Skeletal muscle, RYR1, Malignant hyperthermia and Central core disease. The concepts of his Ryanodine receptor study are interwoven with issues in Mutation and Calcium in biology. While the research belongs to areas of Skeletal muscle, he spends his time largely on the problem of Gene, intersecting his research to questions surrounding Calcium metabolism.
His biological study deals with issues like Molecular biology, which deal with fields such as Missense mutation and DNA extraction. His Malignant hyperthermia research incorporates themes from Internal medicine and Endocrinology. His Cell biology research incorporates elements of Downregulation and upregulation and Calcium.
His primary areas of study are Ryanodine receptor, Skeletal muscle, Internal medicine, Endocrinology and RYR1. The various areas that Francesco Zorzato examines in his Ryanodine receptor study include Biophysics, Malignant hyperthermia and Muscle contraction. His work deals with themes such as Calsequestrin, Myocyte, Endoplasmic reticulum and Calcium, which intersect with Skeletal muscle.
Francesco Zorzato has included themes like mTORC1, Downregulation and upregulation and Point mutation in his Internal medicine study. His study in RYR1 is interdisciplinary in nature, drawing from both Mutation, Centronuclear myopathy and Molecular biology. His study focuses on the intersection of Cell biology and fields such as Receptor with connections in the field of Coactivator and Transcription factor.
RYR1, Skeletal muscle, Calcium, Centronuclear myopathy and Compound heterozygosity are his primary areas of study. His studies examine the connections between RYR1 and genetics, as well as such issues in Mutation, with regards to Missense mutation and Allele. As part of his Internal medicine and Endocrinology and Skeletal muscle studies, Francesco Zorzato is studying Skeletal muscle.
A large part of his Calcium studies is devoted to Ryanodine receptor. His work in the fields of Ryanodine receptor, such as Calsequestrin, intersects with other areas such as Cell type. Francesco Zorzato focuses mostly in the field of Centronuclear myopathy, narrowing it down to matters related to Central core disease and, in some cases, Pathology, Sarcoplasmic reticulum membrane, Nemaline myopathy and Weakness.
His primary scientific interests are in Skeletal muscle, Centronuclear myopathy, RYR1, Metabolism and Pathology. His Skeletal muscle study is concerned with the field of Internal medicine as a whole. His is involved in several facets of Internal medicine study, as is seen by his studies on Myopathy, Calcium metabolism, Calcium and Ryanodine receptor.
His research ties Endocrinology and Myopathy together. The study incorporates disciplines such as Carbohydrate metabolism, GLUT4, Phosphorylation, Cell biology and Retinoic acid in addition to Metabolism. His Pathology study combines topics in areas such as Central core disease, Sarcoplasmic reticulum membrane and Weakness.
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Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia
J Fujii;K Otsu;F Zorzato;S de Leon.
Science (1991)
Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.
F Zorzato;J Fujii;K Otsu;M Phillips.
Journal of Biological Chemistry (1990)
Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.
K Otsu;H F Willard;V K Khanna;F Zorzato.
Journal of Biological Chemistry (1990)
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
C. Florian Bentzinger;Klaas Romanino;Dimitri Cloëtta;Shuo Lin.
Cell Metabolism (2008)
Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia
D H MacLennan;C Duff;F Zorzato;J Fujii.
Nature (1990)
'Calciosome', a cytoplasmic organelle: The inositol 1,4,5-trisphosphate-sensitive Ca2+ store of nonmuscle cells?
Pompeo Volpe;Karl-Heinz Krause;Sadamitsu Hashimoto;Francesco Zorzato.
Proceedings of the National Academy of Sciences of the United States of America (1988)
Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice
Pankaj Shende;Isabelle Plaisance;Christian Morandi;Corinne Pellieux.
Circulation (2011)
Identification of four novel mutations in the C-terminal membrane spanning domain of the ryanodine receptor 1: association with central core disease and alteration of calcium homeostasis
Nikola Tilgen;Francesco Zorzato;Birgit Halliger-Keller;Francesco Muntoni.
Human Molecular Genetics (2001)
Congenital myopathies: disorders of excitation–contraction coupling and muscle contraction
Heinz Jungbluth;Heinz Jungbluth;Heinz Jungbluth;Susan Treves;Susan Treves;Francesco Zorzato;Francesco Zorzato;Anna Sarkozy.
Nature Reviews Neurology (2018)
Congenital muscle disorders with cores: the ryanodine receptor calcium channel paradigm.
Susan Treves;Heinz Jungbluth;Francesco Muntoni;Francesco Zorzato;Francesco Zorzato.
Current Opinion in Pharmacology (2008)
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