D-Index & Metrics Best Publications

David H. MacLennan

University of Toronto
Canada

Biology and Biochemistry

Canada

2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name Citations Publications World Ranking National Ranking

Biology and Biochemistry D-index 98 Citations 31,746 252 World Ranking 1101 National Ranking 25

Research.com Recognitions

Awards & Achievements

2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

What is he best known for?

The fields of study David H. MacLennan is best known for:

Gene
Enzyme
Cardiac muscle

David H. MacLennan merges many fields, such as Endoplasmic reticulum and Amino acid, in his writings. He integrates Amino acid and Transmembrane domain in his research. His research links Receptor with Transmembrane domain. His Transmembrane protein research extends to the thematically linked field of Receptor. He performs multidisciplinary study in Transmembrane protein and Cytoplasm in his work. While working in this field, David H. MacLennan studies both Cytoplasm and Gene. He integrates Gene and Peptide sequence in his research. David H. MacLennan integrates Peptide sequence with Enzyme in his research. In his works, David H. MacLennan conducts interdisciplinary research on Enzyme and Intracellular.

His most cited work include:

Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence (1100 citations)
Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps. (576 citations)
Staining of the Ca2+-binding proteins, calsequestrin, calmodulin, troponin C, and S-100, with the cationic carbocyanine dye “Stains-all”. (385 citations)

What are the main themes of his work throughout his whole career to date

Adenosine triphosphatase and Calcium ATPase are the main topics of his ATPase study. David H. MacLennan links adjacent fields of study such as Anatomy and Endocrinology in the subject of Skeletal muscle. He brings together Anatomy and Biochemistry to produce work in his papers. David H. MacLennan regularly ties together related areas like Adenosine triphosphatase in his Biochemistry studies. His Endocrinology study frequently links to related topics such as Skeletal muscle. While working in this field, David H. MacLennan studies both Endoplasmic reticulum and Cytoplasm. David H. MacLennan connects Cytoplasm with ATPase in his research. David H. MacLennan undertakes multidisciplinary investigations into Cell biology and Biophysics in his work. He conducts interdisciplinary study in the fields of Biophysics and Cell biology through his research.

David H. MacLennan most often published in these fields:

Biochemistry (92.50%)
Endoplasmic reticulum (87.50%)
Cell biology (60.00%)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia

J Fujii;K Otsu;F Zorzato;S de Leon.
Science (1991)

2124 Citations

Amino-acid sequence of a Ca2+ + Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence.

D. H. MacLennan;C. J. Brandl;B. Korczak;N. M. Green.
Nature (1985)

1255 Citations

Phospholamban: a crucial regulator of cardiac contractility

David H. MacLennan;Evangelia G. Kranias.
Nature Reviews Molecular Cell Biology (2003)

1155 Citations

Purification and properties of an adenosine triphosphatase from sarcoplasmic reticulum

David H. MacLennan.
Journal of Biological Chemistry (1970)

1120 Citations

Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.

F Zorzato;J Fujii;K Otsu;M Phillips.
Journal of Biological Chemistry (1990)

818 Citations

Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.

K Otsu;H F Willard;V K Khanna;F Zorzato.
Journal of Biological Chemistry (1990)

810 Citations

Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban.

Joachim P. Schmitt;Mitsuhiro Kamisago;Mitsuhiro Kamisago;Michio Asahi;Guo Hua Li.
Science (2003)

705 Citations

Location of high affinity Ca 2 + -binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca 2+ -ATPase

David M. Clarke;Tip W. Loo;Giuseppe Inesi;David H. MacLennan.
Nature (1989)

697 Citations

Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia

D H MacLennan;C Duff;F Zorzato;J Fujii.
Nature (1990)

650 Citations

Calreticulin Is Essential for Cardiac Development

Nasrin Mesaeli;Kimitoshi Nakamura;Elena Zvaritch;Peter Dickie.
Journal of Cell Biology (1999)

634 Citations

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