David H. MacLennan

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Best Publications

• Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia

  J Fujii;K Otsu;F Zorzato;S de Leon

  2181
  Citations

• Amino-acid sequence of a Ca2+ + Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence.

  D. H. MacLennan;C. J. Brandl;B. Korczak;N. M. Green

  1321
  Citations

• Phospholamban: a crucial regulator of cardiac contractility

  David H. MacLennan;Evangelia G. Kranias

  1256
  Citations

• Purification and properties of an adenosine triphosphatase from sarcoplasmic reticulum

  David H. MacLennan

  1155
  Citations

• Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.

  K Otsu;H F Willard;V K Khanna;F Zorzato

  823
  Citations

• Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.

  F Zorzato;J Fujii;K Otsu;M Phillips

  822
  Citations

• Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps.

  J Lytton;M Westlin;S.E. Burk;G.E. Shull

  807
  Citations

• Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban.

  Joachim P. Schmitt;Mitsuhiro Kamisago;Mitsuhiro Kamisago;Michio Asahi;Guo Hua Li

  746
  Citations

• Location of high affinity Ca 2 + -binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca 2+ -ATPase

  David M. Clarke;Tip W. Loo;Giuseppe Inesi;David H. MacLennan

  700
  Citations

• Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia

  D H MacLennan;C Duff;F Zorzato;J Fujii

  662
  Citations

• Calreticulin Is Essential for Cardiac Development

  Nasrin Mesaeli;Kimitoshi Nakamura;Elena Zvaritch;Peter Dickie

  652
  Citations

• Staining of the Ca2+-binding proteins calsequestrin, calmodulin, troponin C, and S-100, with the cationic carbocyanine dye "Stains-all"

  K P Campbell;D H MacLennan;A O Jorgensen

  591
  Citations

• Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum.

  L. Fliegel;K. Burns;D. H. Maclennan;R. A. F. Reithmeier

  534
  Citations

• Isolation of a high affinity calcium-binding protein from sarcoplasmic reticulum.

  Thomas J. Ostwald;David H. MacLennan

  528
  Citations

• cDNA cloning, functional expression, and mRNA tissue distribution of a third organellar Ca2+ pump.

  S E Burk;J Lytton;D H MacLennan;G E Shull

  514
  Citations

• Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

  Kobra Haghighi;Fotis Kolokathis;Luke Pater;Roy A. Lynch

  508
  Citations

• Adult forms of the Ca2+ATPase of sarcoplasmic reticulum. Expression in developing skeletal muscle.

  C J Brandl;S deLeon;D R Martin;D H MacLennan

  498
  Citations

• Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene.

  J Lytton;D H MacLennan

  477
  Citations

• A mutation in the human ryanodine receptor gene associated with central core disease.

  Zhang Y;Chen Hs;Khanna Vk;De Leon S

  434
  Citations

• A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia.

  Elizabeth F. Gillard;Kinya Otsu;Junichi Fujii;Vijay K. Khanna

  413
  Citations