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Biology and Biochemistry

D-Index
58
Citations
10048
World Ranking
13381
National Ranking
460

Overview

Larry Fliegel is affiliated with the University of Alberta in Canada and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with additional involvement in medicine. Their research spans a broad range of subfields, including molecular biology, cancer research, plant science, cardiology and cardiovascular medicine, and oncology.

The primary topics of Larry Fliegel's work include:

  • Ion Transport and Channel Regulation
  • Cancer, Hypoxia, and Metabolism
  • Ion channel regulation and function
  • Enzyme function and inhibition
  • ATP Synthase and ATPases Research
  • Cancer, Lipids, and Metabolism
  • Cardiac electrophysiology and arrhythmias

Frequently publishing in several venues, Fliegel's most common outlets include:

  • International Journal of Molecular Sciences
  • Molecular and Cellular Biochemistry
  • Preprints.org
  • Gene Expression
  • International Journal of Cardiology

Their recent papers reflect significant areas of study:

  • Role of Genetic Mutations of the Na+/H+ Exchanger Isoform 1, in Human Disease and Protein Targeting and Activity, 2020, Molecular and Cellular Biochemistry
  • Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer, 2020, Reviews of Physiology, Biochemistry and Pharmacology

Larry Fliegel has collaborated frequently with several researchers, including:

  • Tomas Koltai
  • Stephan J. Reshkin
  • Fátima Baltazar
  • Khalid O. Alfarouk
  • Rosa Angela Cardone

The scope of Fliegel's research includes detailed biomolecular investigations into ion exchangers and their roles in disease processes, particularly focusing on the molecular mechanisms behind cancer and cardiovascular conditions. This includes work on ion transport proteins and cellular pH regulation relevant to cancer metabolism and cardiac health.

The diversity of subfields and topics, combined with sustained contributions to leading journals and collaborations with multiple frequent co-authors, demonstrate a multidisciplinary approach focused on understanding molecular and physiological processes related to disease development and treatment strategies.

Best Publications

  • Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum.

    L. Fliegel;K. Burns;D. H. Maclennan;R. A. F. Reithmeier

  • Structural and functional analysis of the Na+/H+ exchanger

    Emily R. Slepkov;Jan K. Rainey;Brian D. Sykes;Larry Fliegel

  • Amino acid sequence of rabbit fast-twitch skeletal muscle calsequestrin deduced from cDNA and peptide sequencing

    Larry Fliegel;Mamoru Ohnishi;Michael R. Carpenter;Vijay K. Khanna

  • Physiological role and regulation of the Na+/H+ exchanger

    Mackenzie E. MaloM.E. Malo;Larry FliegelL. Fliegel

  • Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger

    Xiuju J. Li;Bernando Alvarez;Joseph R. Casey;Reinhart A. F. Reithmeier

  • Regulation of expression and intracellular distribution of calreticulin, a major calcium binding protein of nonmuscle cells.

    Michal Opas;Ewa Dziak;Larry Fliegel;Marek Michalak

  • Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization.

    Annette R. Khaled;Andrea N. Moor;Aiqun Q. Li;Kyungjae Kim

  • Protein Kinase-mediated Regulation of the Na+/H+ Exchanger in the Rat Myocardium by Mitogen-activated Protein Kinase-dependent Pathways *

    Andrea N. Moor;Larry Fliegel

  • Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis

    Schammim R. Amith;Larry Fliegel

  • The Na+/H+ exchanger: an update on structure, regulation and cardiac physiology.

    L Fliegel;O Fröhlich

  • The Na+/H+ exchanger isoform 1.

    Larry Fliegel

  • Ectopic expression of human and feline CD9 in a human B cell line confers beta 1 integrin-dependent motility on fibronectin and laminin substrates and enhanced tyrosine phosphorylation

    Andrew R.E. Shaw;Agatha Domanska;Allan Mak;Anita Gilchrist

  • The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.

    M Karmazyn;M Sawyer;L Fliegel

  • A novel carbonic anhydrase II binding site regulates NHE1 activity

    Xiuju Li;Yongsheng Liu;Bernardo V. Alvarez;Joseph R. Casey

  • Aldosterone Increases NHE-1 Expression and Induces NHE-1-Dependent Hypertrophy in Neonatal Rat Ventricular Myocytes

    Morris Karmazyn;Que Liu;Xiaohong Tracey Gan;Brenda J. Brix

  • Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium.

    Andrea N. Moor;Xiaohong Tracey Gan;Morris Karmazyn;Larry Fliegel

  • Phosphorylation of the C-terminal domain of the Na+/H+ exchanger by Ca2+/calmodulin-dependent protein kinase II.

    L Fliegel;M P Walsh;D Singh;C Wong

  • H2O2-induced Ca2+ overload in NRVM involves ERK1/2 MAP kinases: role for an NHE-1-dependent pathway

    Emily C. Rothstein;Kenneth L. Byron;Ryan E. Reed;Larry Fliegel

  • The high-affinity calcium binding protein of sarcoplasmic reticulum. Tissue distribution, and homology with calregulin.

    Larry Fliegel;Kimberly Burns;Michal Opas;Marek Michalak

  • Regulation of the Na(+)/H(+) exchanger in the healthy and diseased myocardium.

    Larry Fliegel

Frequent Co-Authors

Brian D. Sykes
Brian D. Sykes University of Alberta
Marek Michalak
Marek Michalak University of Alberta
Jason R.B. Dyck
Jason R.B. Dyck University of Alberta
David H. MacLennan
David H. MacLennan University of Toronto
Gary D. Lopaschuk
Gary D. Lopaschuk University of Alberta
Greg G. Goss
Greg G. Goss University of Alberta
Joel H. Weiner
Joel H. Weiner University of Alberta
Carol E. Cass
Carol E. Cass University of Alberta
Joseph R. Casey
Joseph R. Casey University of Alberta

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