D-Index & Metrics Best Publications
Biology and Biochemistry
Canada
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 82 Citations 24,085 255 World Ranking 2328 National Ranking 64

Research.com Recognitions

Awards & Achievements

2023 - Research.com Biology and Biochemistry in Canada Leader Award

2007 - Fellow of the Royal Society of Canada Academy of Science

Overview

What is he best known for?

The fields of study Marek Michalak is best known for:

  • Gene
  • Enzyme
  • Endoplasmic reticulum

His Genetics research extends to the thematically linked field of Endoplasmic reticulum. As part of his studies on Genetics, he often connects relevant subjects like Calreticulin. He incorporates Calreticulin and Unfolded protein response in his studies. He integrates Unfolded protein response and Endoplasmic-reticulum-associated protein degradation in his research. He undertakes multidisciplinary studies into Endoplasmic-reticulum-associated protein degradation and Endoplasmic reticulum in his work. Many of his studies involve connections with topics such as Intracellular and Cell biology. His research on Intracellular often connects related areas such as Cell biology. He performs multidisciplinary study on Biochemistry and Cell in his works. Marek Michalak combines Cell and Biochemistry in his research.

His most cited work include:

  • Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte (1153 citations)
  • Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum (586 citations)
  • Calreticulin Is Essential for Cardiac Development (477 citations)

What are the main themes of his work throughout his whole career to date

His research investigates the connection between Calcium-binding protein and topics such as Calcium that intersect with issues in Organic chemistry. His studies link Calcium with Organic chemistry. He brings together Endoplasmic reticulum and Calnexin to produce work in his papers. His research links Signal transduction with Cell biology. His work in Signal transduction is not limited to one particular discipline; it also encompasses Cell biology. His Biochemistry study frequently draws connections between adjacent fields such as Unfolded protein response. Marek Michalak integrates Calreticulin with Calnexin in his research. In his work, he performs multidisciplinary research in Gene and Genetics. His Genetics study frequently intersects with other fields, such as Calreticulin.

Marek Michalak most often published in these fields:

  • Endoplasmic reticulum (84.34%)
  • Cell biology (83.84%)
  • Biochemistry (63.64%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cell biology (88.00%)
  • Endoplasmic reticulum (64.00%)
  • Biochemistry (52.00%)

In recent works Marek Michalak was focusing on the following fields of study:

As part of his studies on Cell biology, Marek Michalak often connects relevant areas like Embryo. Marek Michalak undertakes interdisciplinary study in the fields of Endoplasmic reticulum and STIM1 through his research. He connects STIM1 with Endoplasmic reticulum in his research. Marek Michalak combines Biochemistry and Biophysics in his research. His multidisciplinary approach integrates Biophysics and Biochemistry in his work. His research brings together the fields of Tauroursodeoxycholic acid and Unfolded protein response. Much of his study explores Tauroursodeoxycholic acid relationship to Unfolded protein response. His Genetics study frequently draws connections between related disciplines such as Pancreatic cancer. His research ties Genetics and Pancreatic cancer together.

Between 2016 and 2021, his most popular works were:

  • LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes (163 citations)
  • Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α (111 citations)
  • TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer (32 citations)

In his most recent research, the most cited works focused on:

  • Gene
  • Endoplasmic reticulum
  • Apoptosis

His Signal transduction study falls within the topics of Wnt signaling pathway and Calcium signaling. He performs multidisciplinary study in Wnt signaling pathway and Signal transduction in his work. His studies link Intracellular with Calcium signaling. Marek Michalak connects Intracellular with Organelle in his research. In his work, Marek Michalak performs multidisciplinary research in Organelle and Endoplasmic reticulum. With his scientific publications, his incorporates both Endoplasmic reticulum and Calreticulin. His Cell biology study frequently intersects with other fields, such as Proteostasis. Proteostasis is closely attributed to Cell biology in his research. Unfolded protein response and Tauroursodeoxycholic acid are commonly linked in his work.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

Shyra J. Gardai;Kathleen A. McPhillips;S. Courtney Frasch;William J. Janssen.
Cell (2005)

1463 Citations

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

Kyungho Lee;Witoon Tirasophon;Xiaohua Shen;Marek Michalak.
Genes & Development (2002)

1188 Citations

Calreticulin: one protein, one gene, many functions.

Marek Michalak;Elaine F. Corbett;Nasrin Mesaeli;Kimitoshi Nakamura.
Biochemical Journal (1999)

905 Citations

Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum

Marek Michalak;Jody Groenendyk;Eva Szabo;Leslie I. Gold.
Biochemical Journal (2009)

672 Citations

Calreticulin Is Essential for Cardiac Development

Nasrin Mesaeli;Kimitoshi Nakamura;Elena Zvaritch;Peter Dickie.
Journal of Cell Biology (1999)

634 Citations

Ca2+ signaling and calcium binding chaperones of the endoplasmic reticulum

M Michalak;J.M Robert Parker;M Opas.
Cell Calcium (2002)

514 Citations

Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum.

L. Fliegel;L. Fliegel;K. Burns;D. H. Maclennan;R. A. F. Reithmeier.
Journal of Biological Chemistry (1989)

505 Citations

Modulation of gene expression by calreticulin binding to the glucocorticoid receptor

K Burns;B Duggan;E A Atkinson;K S Famulski.
Nature (1994)

502 Citations

Calreticulin: non-endoplasmic reticulum functions in physiology and disease

Leslie I. Gold;Paul Eggleton;Mariya T. Sweetwyne;Lauren B. Van Duyn.
The FASEB Journal (2010)

450 Citations

Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis

Kimitoshi Nakamura;Kimitoshi Nakamura;Ella Bossy-Wetzel;Kimberly Burns;Kimberly Burns;Marc P. Fadel.
Journal of Cell Biology (2000)

433 Citations

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