2007 - Fellow of the Royal Society of Canada Academy of Science
Marek Michalak mostly deals with Calreticulin, Endoplasmic reticulum, Cell biology, Biochemistry and Calnexin. His Calreticulin research integrates issues from Phagocytosis, Molecular biology, Thapsigargin, Protein structure and Glucocorticoid receptor. His work carried out in the field of Endoplasmic reticulum brings together such families of science as Calcium-binding protein and Signal transduction.
His work focuses on many connections between Biochemistry and other disciplines, such as Lumen, that overlap with his field of interest in Secretion. His Calnexin research includes themes of Antigen, MHC class I, Transporter associated with antigen processing, Tapasin and Major histocompatibility complex. In the subject of general Unfolded protein response, his work in ATF6 is often linked to Pressure overload, thereby combining diverse domains of study.
His primary scientific interests are in Endoplasmic reticulum, Cell biology, Calreticulin, Biochemistry and Unfolded protein response. As a part of the same scientific study, Marek Michalak usually deals with the Endoplasmic reticulum, concentrating on Calcium-binding protein and frequently concerns with Calcium in biology. Marek Michalak combines topics linked to Cell with his work on Cell biology.
His work deals with themes such as Binding protein, Transcription factor, Immunology, Molecular biology and Internal medicine, which intersect with Calreticulin. His Molecular biology study combines topics from a wide range of disciplines, such as Regulation of gene expression and KDEL. His studies deal with areas such as Myocyte and Skeletal muscle as well as Calsequestrin.
His primary areas of investigation include Cell biology, Endoplasmic reticulum, Unfolded protein response, Calreticulin and Calnexin. His Cell biology study integrates concerns from other disciplines, such as Cell and Transcription factor. His Endoplasmic reticulum research is included under the broader classification of Biochemistry.
His Unfolded protein response research is multidisciplinary, incorporating elements of XBP1, Proteostasis, Signal transduction and Programmed cell death. His study looks at the relationship between Calreticulin and topics such as Cancer research, which overlap with Pancreatic cancer. His Calnexin course of study focuses on Experimental autoimmune encephalomyelitis and Sensitization and Transcellular.
Marek Michalak focuses on Cell biology, Endoplasmic reticulum, Unfolded protein response, Calreticulin and Biochemistry. His study involves Chaperone, Extracellular, Proteostasis, Calnexin and Homeostasis, a branch of Cell biology. His Endoplasmic reticulum research incorporates elements of Endocrinology, Bioinformatics, Transcription factor, Reticular connective tissue and Internal medicine.
His Unfolded protein response study combines topics from a wide range of disciplines, such as Cell, XBP1, Protein folding, Calcium signaling and Programmed cell death. His Calreticulin study incorporates themes from Heart failure, Saccharomyces cerevisiae, Downregulation and upregulation, Immunology and Fibrosis. His Biochemistry research includes themes of Molecular biology and Computational biology.
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Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte
Shyra J. Gardai;Kathleen A. McPhillips;S. Courtney Frasch;William J. Janssen.
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
Kyungho Lee;Witoon Tirasophon;Xiaohua Shen;Marek Michalak.
Genes & Development (2002)
Calreticulin: one protein, one gene, many functions.
Marek Michalak;Elaine F. Corbett;Nasrin Mesaeli;Kimitoshi Nakamura.
Biochemical Journal (1999)
Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum
Marek Michalak;Jody Groenendyk;Eva Szabo;Leslie I. Gold.
Biochemical Journal (2009)
Calreticulin Is Essential for Cardiac Development
Nasrin Mesaeli;Kimitoshi Nakamura;Elena Zvaritch;Peter Dickie.
Journal of Cell Biology (1999)
Ca2+ signaling and calcium binding chaperones of the endoplasmic reticulum
M Michalak;J.M Robert Parker;M Opas.
Cell Calcium (2002)
Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum.
L. Fliegel;L. Fliegel;K. Burns;D. H. Maclennan;R. A. F. Reithmeier.
Journal of Biological Chemistry (1989)
Modulation of gene expression by calreticulin binding to the glucocorticoid receptor
K Burns;B Duggan;E A Atkinson;K S Famulski.
Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis
Kimitoshi Nakamura;Kimitoshi Nakamura;Ella Bossy-Wetzel;Kimberly Burns;Kimberly Burns;Marc P. Fadel.
Journal of Cell Biology (2000)
Expression of calreticulin in Escherichia coli and identification of its Ca2+ binding domains.
S Baksh;M Michalak.
Journal of Biological Chemistry (1991)
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