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David Y. Thomas

David Y. Thomas

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
18735
World Ranking
4165
National Ranking
137

Overview

David Y. Thomas is affiliated with McGill University in Canada. Their research focuses primarily on medical and biochemical sciences, with significant contributions in pulmonary and respiratory medicine as well as molecular biology.

The scientist's work covers major topics including:

  • Cystic Fibrosis Research Advances
  • Neonatal Respiratory Health Research
  • Phosphodiesterase function and regulation
  • Asthma and respiratory diseases
  • Pharmaceutical studies and practices
  • 14-3-3 protein interactions
  • Adenosine and Purinergic Signaling

The main fields of study represented in their publications are Medicine and Biochemistry, Genetics and Molecular Biology. Subfields frequently addressed include Pulmonary and Respiratory Medicine, Molecular Biology, Physiology, Pediatrics, Perinatology and Child Health, and Materials Chemistry.

David Y. Thomas has published extensively in these venues:

  • Scientific Reports
  • Nature Communications
  • American Journal of Respiratory Cell and Molecular Biology
  • ACS Omega
  • Pharmacology & Therapeutics

Recent notable papers include:

  • "Nonspecific binding of common anti-CFTR antibodies in ciliated cells of human airway epithelium" (2021) published in Scientific Reports
  • "Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR" (2022) published in Nature Communications
  • "Cyclic nucleotide phosphodiesterase inhibitors as therapeutic interventions for cystic fibrosis" (2021) published in Pharmacology & Therapeutics
  • "Ionocyte-Specific Regulation of Cystic Fibrosis Transmembrane Conductance Regulator" (2023) published in American Journal of Respiratory Cell and Molecular Biology
  • "The dual phosphodiesterase 3/4 inhibitor RPL554 stimulates rare class III and IV CFTR mutants" (2020) published in American Journal of Physiology-Lung Cellular and Molecular Physiology

Throughout their career, Thomas has frequently collaborated with the following co-authors:

  • John W. Hanrahan
  • Graeme W. Carlile
  • Mark J. Turner
  • Yishan Luo
  • Iris A. L. Silva

Best Publications

  • Association of folding intermediates of glycoproteins with calnexin during protein maturation

    Wei-Jia Ou;Pamela H. Cameron;David Y. Thomas;David Y. Thomas;John J. M. Bergeron

  • Transcription Profiling of Candida albicans Cells Undergoing the Yeast-to-Hyphal Transition

    André Nantel;Daniel Dignard;Catherine Bachewich;Doreen Harcus

  • Roles of the Candida albicans Mitogen-Activated Protein Kinase Homolog, Cek1p, in Hyphal Development and Systemic Candidiasis

    Csilla Csank;Csilla Csank;Klaus Schröppel;Ekkehard Leberer;Doreen Harcus

  • ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER

    Ryo Ushioda;Jun Hoseki;Kazutaka Araki;Gregor Jansen

  • gp25L/emp24/p24 Protein Family Members of the cis-Golgi Network Bind Both COP I and II Coatomer

    Michel Dominguez;Kurt Dejgaard;Joachim Füllekrug;Sophie Dahan

  • Enhanced Catalysis of Ribonuclease B Folding by the Interaction of Calnexin or Calreticulin with ERp57

    André Zapun;André Zapun;Nigel J. Darby;Daniel C. Tessier;Marek Michalak

  • Protein quality control in the ER: The recognition of misfolded proteins

    Pekka Määttänen;Kalle Gehring;John J.M. Bergeron;David Y. Thomas

  • A Role for Myosin-I in Actin Assembly through Interactions with Vrp1p, Bee1p, and the Arp2/3 Complex

    Marie Evangelista;Bert M. Klebl;Amy H.Y. Tong;Bradley A. Webb

  • Htm1p, a mannosidase‐like protein, is involved in glycoprotein degradation in yeast

    Claude A Jakob;Daniel Bodmer;Daniel Bodmer;Urs Spirig;Patrick Bättig

  • A structural overview of the PDI family of proteins.

    Guennadi Kozlov;Pekka Määttänen;David Y. Thomas;Kalle Gehring

  • Ca2+ Regulation of Interactions between Endoplasmic Reticulum Chaperones

    Elaine F. Corbett;Kim Oikawa;Patrice Francois;Daniel C. Tessier

  • Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene.

    Martine Raymond;Philippe Gros;Malcolm Whiteway;David Y. Thomas

  • Proteomics Characterization of Abundant Golgi Membrane Proteins

    Alexander W. Bell;Malcolm A. Ward;Walter P. Blackstock;Hamzah N.M. Freeman

  • Localization of the lectin, ERp57 binding, and polypeptide binding sites of calnexin and calreticulin

    Michael R. Leach;Myrna F. Cohen-Doyle;David Y. Thomas;David B. Williams

  • Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and α-factor precursor processing

    Aleksandra Dmochowska;Daniel Dignard;Dominique Henning;David Y. Thomas

  • Saccharomyces cerevisiae CNE1 Encodes an Endoplasmic Reticulum (ER) Membrane Protein with Sequence Similarity to Calnexin and Calreticulin and Functions as a Constituent of the ER Quality Control Apparatus

    Francesco Parlati;Michel Dominguez;John J.M. Bergeron;David Y. Thomas;David Y. Thomas

  • Conformation-Independent Binding of Monoglucosylated Ribonuclease B to Calnexin

    André Zapun;André Zapun;Stefana M Petrescu;Pauline M Rudd;Raymond A Dwek

  • Drag&Drop cloning in yeast.

    Gregor Jansen;Cunle Wu;Babette Schade;David Y. Thomas

  • Lectin control of protein folding and sorting in the secretory pathway

    Joseph D Schrag;Daniela O Procopio;Miroslaw Cygler;David Y Thomas

  • Cold Adaptation in Budding Yeast

    Babette Schade;Gregor Jansen;Malcolm Whiteway;Karl D. Entian

Frequent Co-Authors

Malcolm Whiteway
Malcolm Whiteway Concordia University
John J. M. Bergeron
John J. M. Bergeron McGill University
John W. Hanrahan
John W. Hanrahan McGill University
Kalle Gehring
Kalle Gehring McGill University
Thierry Vernet
Thierry Vernet French Alternative Energies and Atomic Energy Commission (CEA)
Miroslaw Cygler
Miroslaw Cygler University of Saskatchewan
André Nantel
André Nantel National Research Council Canada
Howard Bussey
Howard Bussey McGill University
Alberto Luini
Alberto Luini National Research Council (CNR)
Ray Wu
Ray Wu Cornell University

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