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John W. Hanrahan

John W. Hanrahan

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
14998
World Ranking
8707
National Ranking
299

Overview

John W. Hanrahan is affiliated with McGill University in Canada and focuses primarily on advancing research in medicine and biochemistry, genetics, and molecular biology. Their work spans several subfields, particularly pulmonary and respiratory medicine, molecular biology, physiology, biomedical engineering, and pediatrics, perinatology, and child health.

Their research covers key topics including cystic fibrosis research advances, neonatal respiratory health research, phosphodiesterase function and regulation, asthma and respiratory diseases, inhalation and respiratory drug delivery, pharmaceutical studies and practices, and advanced biosensing and bioanalysis techniques.

Frequent publication venues for Hanrahan include:

  • Journal of Cystic Fibrosis
  • Scientific Reports
  • Biophysical Journal
  • International Journal of Molecular Sciences
  • Frontiers in Physiology

Hanrahan has collaborated extensively with other researchers in the field. Prominent frequent co-authors include:

  • David Y. Thomas
  • Mark J. Turner
  • Yishan Luo
  • Graeme W. Carlile
  • Daciana Catalina Dumut

Selected recent publications include:

  • CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells, 2021, Frontiers in Physiology
  • Large pH oscillations promote host defense against human airways infection, 2020, The Journal of Experimental Medicine
  • The Phosphodiesterase Inhibitor Ensifentrine Reduces Production of Proinflammatory Mediators in Well Differentiated Bronchial Epithelial Cells by Inhibiting PDE4, 2020, Journal of Pharmacology and Experimental Therapeutics
  • mRNA Delivery: Challenges and Advances through Polymeric Soft Nanoparticles, 2024, International Journal of Molecular Sciences
  • Nonspecific binding of common anti-CFTR antibodies in ciliated cells of human airway epithelium, 2021, Scientific Reports

Best Publications

  • Cutting Edge: 1,25-dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression

    Tian Tian Wang;Frederick P. Nestel;Véronique Bourdeau;Yoshihiko Nagai

  • Phosphorylation-regulated Cl- channel in CHO cells stably expressing the cystic fibrosis gene.

    Joseph A. Tabcharani;Xiu-Bao D Chang;John R. Riordan;John W. Hanrahan

  • Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

    Norbert Kartner;John W. Hanrahan;Tim J. Jensen;A. Leonard Naismith

  • Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites

    Xiu Bao Chang;Joseph A. Tabcharani;Yue Xian Hou;Timothy J. Jensen

  • Multi-ion pore behaviour in the CFTR chloride channel.

    Joseph A. Tabcharani;Johanna M. Rommens;Yue Xian Hou;Xiu Bao Chang

  • Physiology of Epithelial Chloride and Fluid Secretion

    Raymond A. Frizzell;John W. Hanrahan

  • Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.

    C E Bear;F Duguay;A L Naismith;N Kartner

  • A macromolecular complex of β2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA

    Anjaparavanda P. Naren;Bryan Cobb;Chunying Li;Koushik Roy

  • Permeability of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels to Polyatomic Anions

    Paul Linsdell;Joseph A. Tabcharani;Johanna M. Rommens;Yue Xian Hou

  • Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP.

    M. M. Reddy;P. M. Quinton;C. Haws;J. J. Wine

  • Phosphatase inhibitors activate normal and defective CFTR chloride channels.

    Frédéric Becq;Timothy J. Jensen;Xiu Bao Chang;Anna Savoia

  • BAP31 Interacts with Sec61 Translocons and Promotes Retrotranslocation of CFTRΔF508 via the Derlin-1 Complex

    Bing Wang;Hannah Heath-Engel;Donglei Zhang;Nhi Nguyen

  • Disease-associated Mutations in the Fourth Cytoplasmic Loop of Cystic Fibrosis Transmembrane Conductance Regulator Compromise Biosynthetic Processing and Chloride Channel Activity

    Fabian S. Seibert;Paul Linsdell;Tip W. Loo;John W. Hanrahan

  • Correctors of Protein Trafficking Defects Identified by a Novel High-Throughput Screening Assay

    Graeme W. Carlile;Renaud Robert;Donglei Zhang;Katrina A. Teske

  • PLASMA MEMBRANE NA+/H+ EXCHANGER ISOFORMS (NHE-1, -2, AND -3) ARE DIFFERENTIALLY RESPONSIVE TO SECOND MESSENGER AGONISTS OF THE PROTEIN KINASE A AND C PATHWAYS

    Ramani A. Kandasamy;Frank H. Yu;Robert Harris;Annie Boucher

  • A haplotype-based molecular analysis of CFTR mutations associated with respiratory and pancreatic diseases

    Ji Hyun Lee;Ji Ha Choi;Wan Namkung;John W. Hanrahan

  • Lack of CFTR in Skeletal Muscle Predisposes to Muscle Wasting and Diaphragm Muscle Pump Failure in Cystic Fibrosis Mice

    Maziar Divangahi;Haouaria Balghi;Gawiyou Danialou;Alain S. Comtois

  • Structural Analog of Sildenafil Identified as a Novel Corrector of the F508del-CFTR Trafficking Defect

    Renaud Robert;Graeme W. Carlile;Catalin Pavel;Na Liu

  • Cytoplasmic loop three of cystic fibrosis transmembrane conductance regulator contributes to regulation of chloride channel activity.

    Fabian S. Seibert;Paul Linsdell;Tip W. Loo;John W. Hanrahan

  • Oxidant stress suppresses CFTR expression

    André M. Cantin;Ginette Bilodeau;Cristine Ouellet;Jie Liao

Frequent Co-Authors

David Y. Thomas
David Y. Thomas McGill University
John R. Riordan
John R. Riordan University of North Carolina at Chapel Hill
Jeffrey J. Wine
Jeffrey J. Wine Stanford University
Danuta Radzioch
Danuta Radzioch McGill University
Lap-Chee Tsui
Lap-Chee Tsui University of Toronto
David M. Clarke
David M. Clarke University of Toronto
Johanna M. Rommens
Johanna M. Rommens University of Toronto
Tip W. Loo
Tip W. Loo University of Toronto
Frédéric Becq
Frédéric Becq University of Poitiers
Hugo R. de Jonge
Hugo R. de Jonge Erasmus University Rotterdam

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