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Frédéric Becq

Frédéric Becq

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
11137
World Ranking
18600
National Ranking
853

Overview

Frédéric Becq is affiliated with the University of Poitiers in France and specializes in the field of Medicine, with a particular focus on Pulmonary and Respiratory Medicine. Their research contributions span several key subfields, including Molecular Biology, Biomedical Engineering, Genetics, and Plant Science.

The main topics of Becq's research revolve around Cystic Fibrosis Research Advances, Neonatal Respiratory Health Research, Microfluidic and Bio-sensing Technologies, and Inhalation and Respiratory Drug Delivery. They have also worked on Pulmonary Hypertension Research and Treatments, Drug Transport and Resistance Mechanisms, as well as Pediatric Hepatobiliary Diseases and Treatments.

Recent scholarly articles authored or coauthored by Becq include:

  • The rescue of F508del-CFTR by elexacaftor/tezacaftor/ivacaftor (Trikafta) in human airway epithelial cells is underestimated due to the presence of ivacaftor (2021, European Respiratory Journal)

Becq frequently collaborates with other researchers. Notable coauthors include Sandra Mirval, Clarisse Vandebrouck, C. Barrault, Thomas Carrez, and Arnaud Billet. The collaborative nature of their work spans multiple projects and publications.

Their research has been published in a range of scientific journals, with frequent contributions to the European Respiratory Journal, American Journal of Physiology-Lung Cellular and Molecular Physiology, and Revue des Maladies Respiratoires. Additional publication venues include PLoS ONE and Biochemical Pharmacology.

Best Publications

  • Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

    Laurent Meijer;Deborah J Nelson;Vladimir Riazanski;Aida G Gabdoulkhakova

  • Interleukin-1β Secretion Is Impaired by Inhibitors of the Atp Binding Cassette Transporter, ABC1

    Yannick Hamon;Marie Françoise Luciani;Frederic Becq;Bernard Verrier

  • 9-Phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels

    Teddy Grand;Marie Demion;Marie Demion;Caroline Norez;Yvette Mettey

  • Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the α-glucosidase inhibitor miglustat

    Caroline Norez;Sabrina Noel;Martina Wilke;Marcel Bijvelds

  • Phosphatase inhibitors activate normal and defective CFTR chloride channels.

    Frédéric Becq;Timothy J. Jensen;Xiu Bao Chang;Anna Savoia

  • ABC1, an ATP Binding Cassette Transporter Required for Phagocytosis of Apoptotic Cells, Generates a Regulated Anion Flux after Expression in Xenopus laevis Oocytes

    Frédéric Becq;Yannick Hamon;Adriana Bajetto;Maurice Gola

  • Correction of delF508-CFTR activity with benzo(c)quinolizinium compounds through facilitation of its processing in cystic fibrosis airway cells

    Robert L. Dormer;Renaud Dérand;Ceinwen M. McNeilly;Yvette Mettey

  • Development of Substituted Benzo[c]quinolizinium Compounds as Novel Activators of the Cystic Fibrosis Chloride Channel

    Frédéric Becq;Frédéric Becq;Yvette Mettey;Mike A. Gray;Luis J.V. Galietta

  • Tat1, a Novel Sulfate Transporter Specifically Expressed in Human Male Germ Cells and Potentially Linked to RhoGTPase Signaling *

    Aminata Touré;Laurence Morin;Charles Pineau;Frédéric Becq

  • Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis.

    Robert Leslie Dormer;Ceinwen Menai Harris;Zoe Elizabeth Clark;Malcolm Martin Claude Pereira

  • Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl− transport of mouse aortic smooth muscle cells

    Renaud Robert;Caroline Norez;Frédéric Becq

  • Possible regulation of CFTR‐chloride channels by membrane‐bound phosphatases in pancreatic duct cells

    F. Becq;M. Fanjul;M. Merten;C. Figarella

  • The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation

    Baptiste Rode;Thassadite Dirami;Thassadite Dirami;Thassadite Dirami;Naziha Bakouh;Naziha Bakouh;Marthe Rizk-Rabin;Marthe Rizk-Rabin;Marthe Rizk-Rabin

  • Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain

    Norbert Odolczyk;Janine Fritsch;Caroline Norez;Nathalie Servel

  • Pharmacological therapy for cystic fibrosis: From bench to bedside

    Frédéric Becq;Marcus A. Mall;David N. Sheppard;Massimo Conese

  • Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation.

    Clarisse Vandebrouck;Patricia Melin;Caroline Norez;Renaud Robert

  • A Novel Voltage-dependent Chloride Current Activated by Extracellular Acidic pH in Cultured Rat Sertoli Cells

    Céline Auzanneau;Vincent Thoreau;Alain Kitzis;Frédéric Becq

  • Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells.

    Caroline Norez;Fabrice Antigny;Frédéric Becq;Clarisse Vandebrouck

  • Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.

    Fabrice Antigny;Caroline Norez;Frédéric Becq;Clarisse Vandebrouck

  • Synthesis, SAR, Crystal Structure, and Biological Evaluation of Benzoquinoliziniums as Activators of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Channels

    Cécile Marivingt-Mounir;Caroline Norez;Renaud Dérand;Laurence Bulteau-Pignoux

Frequent Co-Authors

Terry D. Butters
Terry D. Butters University of Oxford
Atsushi Kato
Atsushi Kato University of Toyama
Isabelle Callebaut
Isabelle Callebaut Sorbonne University
Bernard Verrier
Bernard Verrier Claude Bernard University Lyon 1
Laurent Meijer
Laurent Meijer Perha Pharmaceuticals
Luis J. V. Galietta
Luis J. V. Galietta Telethon Institute Of Genetics And Medicine
George W. J. Fleet
George W. J. Fleet University of Oxford
John W. Hanrahan
John W. Hanrahan McGill University
Monica Borgatti
Monica Borgatti University of Ferrara
Pierre Boulanger
Pierre Boulanger Claude Bernard University Lyon 1

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