World's Best Scientists 2026 revealed!
Jean-Jacques Toulmé

Jean-Jacques Toulmé

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
9018
World Ranking
16746
National Ranking
702

Overview

Jean-Jacques Toulmé is affiliated with Inserm in France and has contributed extensively to research in biochemistry, genetics, and molecular biology. Their work spans molecular biology as the primary subfield, with additional efforts in biomedical engineering, pollution studies, and infectious diseases.

Toulmé's research focuses on advanced biosensing and bioanalysis techniques, biosensors and analytical detection, DNA and nucleic acid chemistry, pesticide and herbicide environmental studies, RNA interference and gene delivery, extracellular vesicles in disease, and SARS-CoV-2 detection and testing.

  • Advanced biosensing and bioanalysis techniques
  • Biosensors and Analytical Detection
  • DNA and Nucleic Acid Chemistry
  • Pesticide and Herbicide Environmental Studies
  • RNA Interference and Gene Delivery
  • Extracellular vesicles in disease
  • SARS-CoV-2 detection and testing

The scientist has published in several venues, including Nature Communications, Analytica Chimica Acta, Talanta, Analytical Chemistry, and Macromolecular Bioscience.

  • Nature Communications
  • Analytica Chimica Acta
  • Talanta
  • Analytical Chemistry
  • Macromolecular Bioscience

Frequent collaborators include Arghya Sett, Lorena Zara, Eric Dausse, Corinne Nardin, and Francesco Millozzi.

  • Arghya Sett
  • Lorena Zara
  • Eric Dausse
  • Corinne Nardin
  • Francesco Millozzi

Representative recent publications include:

  • "Anti-pesticide DNA aptamers fail to recognize their targets with asserted micromolar dissociation constants," 2021, Analytica Chimica Acta
  • "A malachite green light-up aptasensor for the detection of theophylline," 2021, Talanta
  • "Aptamer-conjugated gold nanoparticles enable oligonucleotide delivery into muscle stem cells to promote regeneration of dystrophic muscles," 2025, Nature Communications
  • "Engineering Light-Up Aptamers for the Detection of RNA Hairpins through Kissing Interaction," 2020, Analytical Chemistry
  • "Glyphosate-Exonuclease Interactions: Reduced Enzymatic Activity as a Route to Glyphosate Biosensing," 2023, Macromolecular Bioscience

Best Publications

  • Specific regulation of gene expression by antisense, sense and antigene nucleic acids.

    Claude Hélène;Jean-Jacques Toulmé

  • Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

    C. Cazenave;C.A. Stein;N. Loreau;N.T. Thuong

  • Enzymatic amplification of translation inhibition of rabbit β-globin mRNA mediated by anti-messenger oligodeoxynucleotides covalently linked to intercalating agents

    Christian Cazenave;Nadine Loreau;Nguyen T. Thuong;Jean-Jacques Toulmé

  • Improved leishmanicidal effect of phosphorotioate antisense oligonucleotides by LDL-mediated delivery

    Rakesh Kumar Mishra;Catherine Moreau;Claude Ramazeilles;Serge Moreau

  • In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1.

    Frédéric Ducongé;Jean-Jacques Toulmé

  • Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism

    Claudine Boiziau;Robin Kurfurst;Christian Cazenave;Victoria Roig

  • DNA Aptamers Selected Against the HIV-1trans-Activation-responsive RNA Element Form RNA-DNA Kissing Complexes

    Claudine Boiziau;Eric Dausse;Ludmila Yurchenko;Jean-Jacques Toulmé

  • DNA aptamers selected against the HIV-1 RNase H display in vitro antiviral activity.

    Marie-Line Andreola;Frédéric Pileur;Christina Calmels;Michel Ventura

  • Antimessenger oligodeoxyribonucleotides: an alternative to antisense RNA for artificial regulation of gene expression--a review.

    J.-J. Toulmé;C. Hélène

  • New candidates for true antisense.

    Jean-Jacques Toulmé;Jean-Jacques Toulmé

  • A tryptophan-containing peptide recognizes and cleaves DNA at apurinic sites

    Tula Behmoaras;Jean-Jacques Toulmé;Claude Hélène

  • Specific inhibition of mRNA translation by complementary oligonucleotides covalently linked to intercalating agents.

    J J Toulmé;H M Krisch;N Loreau;N T Thuong

  • Is a closing "GA pair" a rule for stable loop-loop RNA complexes?

    Frédéric Ducongé;Carmelo Di Primo;Jean-Jacques Toulmé

  • An acridine-linked oligodeoxynucleotide targeted to the common 5' end of trypanosome mRNAs kills cultured parasites.

    P. Verspieren;A.W.C.A. Cornelissen;N.T. Thuong;C. Hélène

  • LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV‐1

    Fabien Darfeuille;Jens Bo Hansen;Henrik Orum;Carmelo Di Primo

  • Oligodeoxynucleotides covalently linked to intercalating agents: a new class of gene regulatory substances.

    C. Hélène;T. Montenay-Garestier;T. Saison;M. Takasugi

  • Selective inhibitory DNA aptamers of the human RNase H1

    Frédéric Pileur;Marie‐Line Andreola;Eric Dausse;Justine Michel

  • Aptamers: a new class of oligonucleotides in the drug discovery pipeline?

    Eric Dausse;Eric Dausse;Sonia Da Rocha Gomes;Jean-Jacques Toulmé;Jean-Jacques Toulmé

  • Comparative analysis of translation efficiencies of hepatitis C virus 5' untranslated regions among intraindividual quasispecies present in chronic infection: opposite behaviors depending on cell type.

    Julien Laporte;Isabelle Malet;Thibault Andrieu;Vincent Thibault

  • New ways of initiating translation in eukaryotes? [2](multiple letters)

    R. Schneider;V. I. Agol;R. Andino;F. Bayard

Frequent Co-Authors

Claude Hélène
Claude Hélène Grenoble Alpes University
Michael J. Gait
Michael J. Gait MRC Laboratory of Molecular Biology
Michèle Allard
Michèle Allard Centre national de la recherche scientifique, CNRS
Sergei M. Gryaznov
Sergei M. Gryaznov MAIA Biotechnology, Inc.
David L. Bryce
David L. Bryce University of Ottawa
Jack S. Cohen
Jack S. Cohen Ben-Gurion University of the Negev
Laura M. Lechuga
Laura M. Lechuga Spanish National Research Council
John J. Rossi
John J. Rossi City Of Hope National Medical Center

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