His scientific interests lie mostly in Oligonucleotide, Molecular biology, Biochemistry, Aptamer and DNA. His research on Oligonucleotide also deals with topics like
His work on Nuclease, Phosphodiester bond and Antisense oligonucleotides as part of general Biochemistry study is frequently connected to Conjugate, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. His Aptamer research integrates issues from RNA, Systematic evolution of ligands by exponential enrichment and Surface plasmon resonance. The various areas that Jean-Jacques Toulmé examines in his DNA study include Nucleic acid and RNase H.
Jean-Jacques Toulmé mainly focuses on Oligonucleotide, RNA, Aptamer, Molecular biology and Biochemistry. His Oligonucleotide research is under the purview of DNA. His work carried out in the field of DNA brings together such families of science as Polynucleotide, Nucleic acid, Nucleotide and Sense.
His work deals with themes such as Base pair, Transcription and Cell biology, which intersect with RNA. His studies in Aptamer integrate themes in fields like Biophysics, Computational biology, Combinatorial chemistry, Surface plasmon resonance and Systematic evolution of ligands by exponential enrichment. His Molecular biology study integrates concerns from other disciplines, such as Complementary DNA, Messenger RNA and Reverse transcriptase, RNase H.
His primary scientific interests are in Aptamer, Systematic evolution of ligands by exponential enrichment, Oligonucleotide, RNA and Computational biology. The Aptamer study combines topics in areas such as Biochemistry, Nucleic acid, Ligand, Biophysics and Combinatorial chemistry. He usually deals with Nucleic acid and limits it to topics linked to DNA and Phosphodiester bond.
In the subject of general Systematic evolution of ligands by exponential enrichment, his work in SELEX Aptamer Technique is often linked to Selection, thereby combining diverse domains of study. His Oligonucleotide study typically links adjacent topics like Biosensor. His RNA research includes themes of Base pair and Surface plasmon resonance.
Jean-Jacques Toulmé mostly deals with Aptamer, Systematic evolution of ligands by exponential enrichment, Surface plasmon resonance, RNA and Biophysics. His research brings together the fields of Biochemistry and Aptamer. His studies in Biochemistry integrate themes in fields like Molecular biology and Fluorescence anisotropy.
His Systematic evolution of ligands by exponential enrichment research integrates issues from Oligonucleotide, DNA, Nucleic acid and Small molecule. His biological study spans a wide range of topics, including G-quadruplex and Binding site. His RNA study frequently draws connections to other fields, such as Nucleotide.
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Specific regulation of gene expression by antisense, sense and antigene nucleic acids.
Claude Hélène;Jean-Jacques Toulmé.
Biochimica et Biophysica Acta (1990)
Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides
C. Cazenave;C.A. Stein;N. Loreau;N.T. Thuong.
Nucleic Acids Research (1989)
Enzymatic amplification of translation inhibition of rabbit β-globin mRNA mediated by anti-messenger oligodeoxynucleotides covalently linked to intercalating agents
Christian Cazenave;Nadine Loreau;Nguyen T. Thuong;Jean-Jacques Toulmé.
Nucleic Acids Research (1987)
Improved leishmanicidal effect of phosphorotioate antisense oligonucleotides by LDL-mediated delivery
Rakesh Kumar Mishra;Catherine Moreau;Claude Ramazeilles;Serge Moreau.
Biochimica et Biophysica Acta (1995)
In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1.
Frédéric Ducongé;Jean-Jacques Toulmé.
Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism
Claudine Boiziau;Robin Kurfurst;Christian Cazenave;Victoria Roig.
Nucleic Acids Research (1991)
DNA Aptamers Selected Against the HIV-1trans-Activation-responsive RNA Element Form RNA-DNA Kissing Complexes
Claudine Boiziau;Eric Dausse;Ludmila Yurchenko;Jean-Jacques Toulmé.
Journal of Biological Chemistry (1999)
Antimessenger oligodeoxyribonucleotides: an alternative to antisense RNA for artificial regulation of gene expression--a review.
J.-J. Toulmé;C. Hélène.
DNA aptamers selected against the HIV-1 RNase H display in vitro antiviral activity.
Marie-Line Andreola;Frédéric Pileur;Christina Calmels;Michel Ventura.
New candidates for true antisense.
Jean-Jacques Toulmé;Jean-Jacques Toulmé.
Nature Biotechnology (2001)
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