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Jean-Louis Mergny

Jean-Louis Mergny

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Molecular Biology
France
2025
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Genetics and Molecular Biology
France
2024

D-Index & Metrics

Molecular Biology

D-Index
97
Citations
42219
World Ranking
587
National Ranking
14

Research.com Recognitions

  • 2025 - Research.com Molecular Biology in France Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in France Leader Award
  • 2023 - Research.com Molecular Biology in France Leader Award
  • 2019 - Member of Academia Europaea

Overview

Jean-Louis Mergny is affiliated with Inserm in France and works extensively in the field of Biochemistry, Genetics, and Molecular Biology. Their research focuses primarily on Molecular Biology, with additional work spanning Ecology, Plant Science, Materials Chemistry, and Organic Chemistry.

The scientist's main topics of research include:

  • DNA and Nucleic Acid Chemistry
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • RNA and protein synthesis mechanisms
  • Bacteriophages and microbial interactions
  • Genomics and Chromatin Dynamics
  • Plant Virus Research Studies

Jean-Louis Mergny has contributed to a significant number of publications in various academic venues. The most frequent publication venues include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature (29 publications)
  • Nucleic Acids Research (15 publications)
  • Biochimie (10 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (7 publications)
  • Angewandte Chemie International Edition (5 publications)

The scientist has collaborated frequently with other researchers, including:

  • Jun Zhou (26 collaborations)
  • Huangxian Ju (21 collaborations)
  • Anne Cucchiarini (20 collaborations)
  • Václav Brázda (19 collaborations)
  • Mingpan Cheng (18 collaborations)

Some of the recent papers authored or co-authored by Jean-Louis Mergny include:

  • "G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies," 2020, Trends in Molecular Medicine
  • "Unlocking G-Quadruplexes as Antiviral Targets," 2021, Pharmacological Reviews
  • "G-quadruplex ligands in cancer therapy: Progress, challenges, and clinical perspectives," 2024, Life Sciences
  • "SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction," 2021, Nucleic Acids Research
  • "Thermal and pH Stabilities of i-DNA: Confronting in vitro Experiments with Models and In-Cell NMR Data," 2021, Angewandte Chemie International Edition

In 2019, Jean-Louis Mergny was recognized as a Member of Academia Europaea, reflecting their involvement in the wider European scientific community.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Analysis of thermal melting curves

    Jean-Louis Mergny;Laurent Lacroix

  • Following G-quartet formation by UV-spectroscopy

    Jean-Louis Mergny;Anh-Tuan Phan;Laurent Lacroix

  • Targeting telomeres and telomerase

    Anne De Cian;Laurent Lacroix;Laurent Lacroix;Céline Douarre;Nassima Temime-Smaali

  • Re-evaluation of G-quadruplex propensity with G4Hunter

    Amina Bedrat;Laurent Lacroix;Jean-Louis Mergny

  • Human telomeric DNA: G‐quadruplex, i‐motif and Watson–Crick double helix

    Anh Tuân Phan;Jean‐Louis Mergny

  • Thermal difference spectra: a specific signature for nucleic acid structures

    Jean-Louis Mergny;Jing Li;Laurent Lacroix;Samir Amrane

  • Natural and pharmacological regulation of telomerase

    Jean-Louis Mergny;Jean-François Riou;Patrick Mailliet;Marie-Paule Teulade-Fichou

  • Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

    J. F. Riou;L. Guittat;P. Mailliet;A. Laoui

  • G-quadruplex DNA: A target for drug design

    Jean-Louis Mergny;Claude Hélène

  • Highly Efficient G-Quadruplex Recognition by Bisquinolinium Compounds

    Anne De Cian;Elsa Delemos;Jean-Louis Mergny;Marie-Paule Teulade-Fichou

  • How long is too long? Effects of loop size on G-quadruplex stability

    Aurore Guédin;Julien Gros;Patrizia Alberti;Jean-Louis Mergny

  • DNA duplex–quadruplex exchange as the basis for a nanomolecular machine

    Patrizia Alberti;Jean-Louis Mergny

  • Fluorescence-based melting assays for studying quadruplex ligands

    Anne De Cian;Lionel Guittat;Markus Kaiser;Barbara Saccà

  • G-quadruplexes and helicases.

    Oscar Mendoza;Anne Bourdoncle;Anne Bourdoncle;Jean-Baptiste Boulé;Jean-Baptiste Boulé;Robert M. Brosh

  • Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay.

    Jean-Louis Mergny;Laurent Lacroix;Marie-Paule Teulade-Fichou;Candide Hounsou

  • Thioflavin T as a fluorescence light-up probe for G4 formation

    Amandine Renaud de la Faverie;Aurore Guédin;Amina Bedrat;Liliya A. Yatsunyk

  • The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

    Cyril Ribeyre;Judith Lopes;Jean Baptiste Boulé;Jean Baptiste Boulé;Aurèle Piazza

  • Intramolecular Folding of Pyrimidine Oligodeoxynucleotides into an i-DNA Motif

    Jean-Louis Mergny;Laurent Lacroix;Xiaogang Han;Jean-Louis Leroy

  • Triple Helix-Specific Ligands

    J. L. Mergny;G. Duval-Valentin;C. H. Nguyen;L. Perrouault

Frequent Co-Authors

Marie-Paule Teulade-Fichou
Marie-Paule Teulade-Fichou University of Paris-Saclay
Jean-François Riou
Jean-François Riou French National Museum of Natural History
Claude Hélène
Claude Hélène Grenoble Alpes University
Valérie Gabelica
Valérie Gabelica University of Bordeaux
João A. Queiroz
João A. Queiroz University of Beira Interior
Dik-Lung Ma
Dik-Lung Ma Hong Kong Baptist University
Chung-Hang Leung
Chung-Hang Leung University of Macau
Huangxian Ju
Huangxian Ju Nanjing University
Jiří Šponer
Jiří Šponer Masaryk University
Jean-Marie Lehn
Jean-Marie Lehn University of Strasbourg

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