D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 84 Citations 21,469 259 World Ranking 829 National Ranking 17

Research.com Recognitions

Awards & Achievements

2019 - Member of Academia Europaea

Overview

What is he best known for?

The fields of study he is best known for:

  • DNA
  • Gene
  • Enzyme

Jean-Louis Mergny spends much of his time researching DNA, G-quadruplex, Biochemistry, Oligonucleotide and Telomerase. His DNA study incorporates themes from RNA, Stereochemistry, Guanine and Förster resonance energy transfer. G-quadruplex is a primary field of his research addressed under Genetics.

The Biochemistry study which covers Aptamer that intersects with Luminescence, Tyrosine, Bipyridine, Iridium and Imidazole. The Oligonucleotide study combines topics in areas such as Biophysics, Nucleic acid and Fluorescein. His studies in Telomerase integrate themes in fields like Telomere and In vitro.

His most cited work include:

  • Following G-quartet formation by UV-spectroscopy (520 citations)
  • Analysis of thermal melting curves (491 citations)
  • Targeting telomeres and telomerase (477 citations)

What are the main themes of his work throughout his whole career to date?

Jean-Louis Mergny mainly investigates G-quadruplex, DNA, Stereochemistry, Biochemistry and Oligonucleotide. His research integrates issues of RNA, Biophysics, Guanine, Circular dichroism and Combinatorial chemistry in his study of G-quadruplex. Jean-Louis Mergny combines subjects such as Nucleic acid, Crystallography, Molecular biology, Telomerase and Förster resonance energy transfer with his study of DNA.

His work carried out in the field of Telomerase brings together such families of science as Telomere, Cancer therapy and Cancer research. The study incorporates disciplines such as Selectivity, Molecule, Ligand and Binding site in addition to Stereochemistry. His work deals with themes such as Duplex, Base pair and Triple helix, which intersect with Oligonucleotide.

He most often published in these fields:

  • G-quadruplex (86.53%)
  • DNA (76.42%)
  • Stereochemistry (32.90%)

What were the highlights of his more recent work (between 2018-2021)?

  • G-quadruplex (86.53%)
  • DNA (76.42%)
  • RNA (22.02%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in G-quadruplex, DNA, RNA, Guanine and Biophysics. His G-quadruplex research includes elements of Deoxyribozyme, Computational biology and Nucleic acid. Jean-Louis Mergny focuses mostly in the field of Nucleic acid, narrowing it down to topics relating to Combinatorial chemistry and, in certain cases, Selectivity.

His work on Base pair as part of general DNA study is frequently linked to Stability, therefore connecting diverse disciplines of science. Jean-Louis Mergny has researched RNA in several fields, including Molecular biology, Genome, Archaea and Dictyostelium discoideum. His studies deal with areas such as Folding and Ligand as well as Biophysics.

Between 2018 and 2021, his most popular works were:

  • DNA Quadruple Helices in Nanotechnology. (81 citations)
  • DNA Quadruple Helices in Nanotechnology. (81 citations)
  • Involvement of G-quadruplex regions in mammalian replication origin activity (40 citations)

In his most recent research, the most cited papers focused on:

  • DNA
  • Gene
  • Enzyme

His primary areas of investigation include G-quadruplex, DNA, Gene, Genome and Cancer cell. Jean-Louis Mergny performs integrative G-quadruplex and Phagolysosome research in his work. His study looks at the intersection of DNA and topics like RNA with Nucleic acid sequence, Guanine and World Wide Web.

His studies in Genome integrate themes in fields like Transcriptional regulation, Promoter, Reporter gene, Exon and Regulation of gene expression. The various areas that Jean-Louis Mergny examines in his Cancer cell study include Autophagy, ATG5, DNA damage, Cell growth and Aptamer. As part of one scientific family, Jean-Louis Mergny deals mainly with the area of Computational biology, narrowing it down to issues related to the QUARFLOXIN, and often Nucleic acid.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Following G-quartet formation by UV-spectroscopy

Jean-Louis Mergny;Anh-Tuan Phan;Laurent Lacroix.
FEBS Letters (1998)

714 Citations

Analysis of thermal melting curves

Jean-Louis Mergny;Laurent Lacroix.
Oligonucleotides (2003)

694 Citations

Targeting telomeres and telomerase

Anne De Cian;Laurent Lacroix;Laurent Lacroix;Céline Douarre;Nassima Temime-Smaali.
Biochimie (2008)

619 Citations

Natural and pharmacological regulation of telomerase

Jean-Louis Mergny;Jean-François Riou;Patrick Mailliet;Marie-Paule Teulade-Fichou.
Nucleic Acids Research (2002)

498 Citations

Human telomeric DNA: G‐quadruplex, i‐motif and Watson–Crick double helix

Anh Tuân Phan;Jean‐Louis Mergny.
Nucleic Acids Research (2002)

483 Citations

Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

J. F. Riou;L. Guittat;P. Mailliet;A. Laoui.
Proceedings of the National Academy of Sciences of the United States of America (2002)

465 Citations

G-quadruplex DNA: A target for drug design

Jean-Louis Mergny;Claude Hélène.
Nature Medicine (1998)

451 Citations

DNA duplex–quadruplex exchange as the basis for a nanomolecular machine

Patrizia Alberti;Jean-Louis Mergny.
Proceedings of the National Academy of Sciences of the United States of America (2003)

446 Citations

Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay.

Jean-Louis Mergny;Laurent Lacroix;Marie-Paule Teulade-Fichou;Candide Hounsou.
Proceedings of the National Academy of Sciences of the United States of America (2001)

378 Citations

Thermal difference spectra: a specific signature for nucleic acid structures

Jean-Louis Mergny;Jing Li;Laurent Lacroix;Samir Amrane.
Nucleic Acids Research (2005)

377 Citations

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