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Chemistry

D-Index
47
Citations
7197
World Ranking
15728
National Ranking
2436

Overview

Jia-Heng Tan is a researcher primarily affiliated with Sun Yat-sen University in China. Their academic work focuses largely on the field of Biochemistry, Genetics, and Molecular Biology, with a strong emphasis on Molecular Biology. Other subfields of study include Materials Chemistry, Biochemistry, Spectroscopy, and Cellular and Molecular Neuroscience.

Their research covers several main topics:

  • DNA and Nucleic Acid Chemistry
  • Advanced biosensing and bioanalysis techniques
  • RNA and protein synthesis mechanisms
  • RNA Interference and Gene Delivery
  • RNA modifications and cancer
  • Mitochondrial Function and Pathology
  • RNA Research and Splicing

Jia-Heng Tan has contributed to multiple publications, including notable papers such as:

  • Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis, 2021, Journal of the American Chemical Society
  • Recent advances in fluorescent probes for G-quadruplex nucleic acids, 2020, Biochemical and Biophysical Research Communications
  • Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors, 2020, Journal of Medicinal Chemistry
  • Visualization of ligand-induced c-MYC duplex-quadruplex transition and direct exploration of the altered c-MYC DNA-protein interactions in cells, 2022, Nucleic Acids Research
  • Construction of a TICT-AIE-Integrated Unimolecular Platform for Imaging Lipid Droplet-Mitochondrion Interactions in Live Cells and In Vivo, 2022, ACS Sensors

Their frequent coauthors include:

  • Zhi-Shu Huang
  • Shuo-Bin Chen
  • Xiu-Cai Chen
  • Gui-Xue Tang
  • Shuo-Bin Chen

Jia-Heng Tan's research has been published extensively in several recurring venues, such as:

  • Journal of Medicinal Chemistry
  • Analytical Chemistry
  • Bioorganic Chemistry
  • Sensors and Actuators B Chemical
  • Molecules

Best Publications

  • G-Quadruplexes: Targets in Anticancer Drug Design

    Tian Miao Ou;Yu Jing Lu;Jia Heng Tan;Zhi Shu Huang

  • Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives

    Tian-Miao Ou;Yu-Jing Lu;Chi Zhang;Zhi-Shu Huang

  • Tracking the Dynamic Folding and Unfolding of RNA G-Quadruplexes in Live Cells.

    Xiu-Cai Chen;Shuo-Bin Chen;Jing Dai;Jia-Hao Yuan

  • 5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation.

    Yu Jing Lu;Tian Miao Ou;Jia Heng Tan;Jin Qiang Hou

  • 9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc

    Yan Ma;Tian-Miao Ou;Jin-Qiang Hou;Yu-Jing Lu

  • Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe

    Shuo-Bin Chen;Ming-Hao Hu;Guo-Cai Liu;Jin Wang

  • Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.

    Ming-Hao Hu;Shuo-Bin Chen;Bo Wang;Tian-Miao Ou

  • Inhibition of Cell Proliferation by Quindoline Derivative (SYUIQ-05) through its Preferential Interaction with c-myc Promoter G-Quadruplex

    Tian-Miao Ou;Jing Lin;Yu-Jing Lu;Jin-Qiang Hou

  • Conformation Selective Antibody Enables Genome Profiling and Leads to Discovery of Parallel G-Quadruplex in Human Telomeres

    Hui-Yun Liu;Qi Zhao;Tian-Peng Zhang;Yue Wu

  • Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60 L scale fermentation of the deep sea-derived Marinactinospora thermotolerans SCSIO 00652

    Xiao Zhou;Hongbo Huang;Yuchan Chen;Jiaheng Tan

  • Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex.

    Ming-Hao Hu;Ming-Hao Hu;Yu-Qing Wang;Ze-Yi Yu;Lu-Ni Hu

  • Turning off Transcription of the bcl-2 Gene by Stabilizing the bcl-2 Promoter Quadruplex with Quindoline Derivatives

    Xiao-Dong Wang;Tian-Miao Ou;Yu-Jing Lu;Zeng Li

  • Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer’s disease

    Shang-Ying Chen;Yuan Chen;Yan-Ping Li;Shu-Han Chen

  • Isaindigotone derivatives: a new class of highly selective ligands for telomeric G-quadruplex DNA.

    Jia Heng Tan;Tian Miao Ou;Jin Qiang Hou;Yu Jing Lu

  • Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation.

    Wen Luo;Yan-Ping Li;Yan He;Shi-Liang Huang

  • Identification of G-Quadruplex-Binding Protein from the Exploration of RGG Motif/G-Quadruplex Interactions.

    Zhou-Li Huang;Jing Dai;Wen-Hua Luo;Xiang-Gui Wang

  • Design of Selective G-quadruplex Ligands as Potential Anticancer Agents

    Jia-Heng Tan;Lian-Quan Gu;Jian-Yong Wu

  • Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry

    De-Ying Zeng;Guo-Tao Kuang;Shi-Ke Wang;Wang Peng

  • Targeting G-quadruplex nucleic acids with heterocyclic alkaloids and their derivatives

    Yun-Xia Xiong;Zhi-Shu Huang;Jia-Heng Tan

  • Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin

    Jia-Heng Tan;Yu-jing Lu;Zhi-Shu Huang;Lian-Quan Gu

  • Stabilization of G-quadruplex DNA by C-5-methyl-cytosine in bcl-2 promoter: implications for epigenetic regulation.

    Jing Lin;Jin-qiang Hou;Han-dan Xiang;Yi-yong Yan

  • Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.

    Yan He;Pei-Fen Yao;Shuo-bin Chen;Zhi-hong Huang

  • Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands.

    Yan Ma;Tian-Miao Ou;Jia-Heng Tan;Jin-Qiang Hou

Frequent Co-Authors

Zhi-Shu Huang
Zhi-Shu Huang Sun Yat-sen University
Tian-Miao Ou
Tian-Miao Ou Sun Yat-sen University
Xudong Wang
Xudong Wang University of Wisconsin–Madison
Jian-Yong Wu
Jian-Yong Wu Hong Kong Polytechnic University
Lei Zhang
Lei Zhang South China University of Technology
Qinghong Zhang
Qinghong Zhang Xiamen University
Dik-Lung Ma
Dik-Lung Ma Hong Kong Baptist University
Kwok-Yin Wong
Kwok-Yin Wong Hong Kong Polytechnic University
Albert S. C. Chan
Albert S. C. Chan Sun Yat-sen University
Jin Wang
Jin Wang Stony Brook University

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