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Mauro Freccero

Mauro Freccero

D-Index & Metrics

Chemistry

D-Index
44
Citations
5812
World Ranking
16999
National Ranking
663

Overview

Mauro Freccero is affiliated with the University of Pavia in Italy. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Chemistry, with significant contributions to several interrelated subfields including Molecular Biology, Organic Chemistry, and Materials Chemistry.

Their recent scholarly output includes studies published in established scientific journals. Notable papers include:

  • Selective targeting of mutually exclusive DNA G-quadruplexes: HIV-1 LTR as paradigmatic model, 2020, Nucleic Acids Research
  • On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model, 2020, International Journal of Biological Macromolecules
  • G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action, 2021, Journal of Medicinal Chemistry
  • Trifunctionalized Naphthalene Diimides and Dimeric Analogues as G-Quadruplex-Targeting Anticancer Agents Selected by Affinity Chromatography, 2020, International Journal of Molecular Sciences
  • On the interaction of an anticancer trisubstituted naphthalene diimide with G-quadruplexes of different topologies: a structural insight, 2020, Nucleic Acids Research

Their work often explores DNA and nucleic acid chemistry with particular emphasis on G-quadruplex structures. Key research topics include:

  • DNA and Nucleic Acid Chemistry
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Multicomponent Synthesis of Heterocycles
  • Synthesis and biological activity

Mauro Freccero has published extensively in various scientific venues. The most frequent publication outlets are:

  • The Cambridge Structural Database
  • Nucleic Acids Research
  • Molecules
  • Journal of Medicinal Chemistry
  • International Journal of Biological Macromolecules

Frequent collaborators in their research include:

  • Filippo Doria
  • Valentina Pirota
  • Alakbar Huseynzada
  • Haji Vahid Akhundzada
  • Sarra Soudani

Their investigations often intersect specialized subfields such as spectroscopy and computational theory and mathematics, indicating a multidisciplinary approach to addressing complex biochemical and chemical problems.

Best Publications

  • Substituents on quinone methides strongly modulate formation and stability of their nucleophilic adducts.

    Emily E. Weinert;Ruggero Dondi;Stefano Colloredo-Melz;Kristen N. Frankenfield

  • Dynamics of .alpha.-CH Deprotonation and .alpha.-Desilylation Reactions of Tertiary Amine Cation Radicals

    Xiaoming Zhang;Xiaoming Zhang;Xiaoming Zhang;Syun Ru Yeh;Syun Ru Yeh;Syun Ru Yeh;Seok Hong;Seok Hong;Seok Hong;Mauro Freccero;Mauro Freccero;Mauro Freccero

  • Alkylation of amino acids and glutathione in water by o-quinone methide. Reactivity and selectivity.

    Emilia Modica;Riccardo Zanaletti;Mauro Freccero;Mariella Mella

  • Quinone Methides Tethered to Naphthalene Diimides as Selective G-Quadruplex Alkylating Agents

    Marco Di Antonio;Filippo Doria;Sara N. Richter;Carolina Bertipaglia

  • Photosensitized Oxidation of Sulfides: Discriminating between the Singlet-Oxygen Mechanism and Electron Transfer Involving Superoxide Anion or Molecular Oxygen

    Sergio M. Bonesi;Sergio M. Bonesi;Ilse Manet;Mauro Freccero;Maurizio Fagnoni

  • Binol Quinone Methides as Bisalkylating and DNA Cross-Linking Agents

    Sara N Richter;Stefano Maggi;Stefano Colloredo Mels;Manlio Palumbo

  • Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes.

    Rosalba Perrone;Filippo Doria;Elena Butovskaya;Ilaria Frasson

  • New synthetic methods via radical cation fragmentation

    Mariella Mella;Mauro Freccero;Elisa Fasani;Angelo Albini

  • Photogeneration and reactivity of naphthoquinone methides as purine selective DNA alkylating agents.

    Daniela Verga;Matteo Nadai;Filippo Doria;Claudia Percivalle

  • Concerted vs stepwise mechanism in 1,3-dipolar cycloaddition of nitrone to ethene, cyclobutadiene, and benzocyclobutadiene. A computational study

    Di Valentin C;Freccero M;Gandolfi R;Rastelli A

  • A new method in radical chemistry: Generation of radicals by photo-induced electron transfer and fragmentation of the radical cation

    Angelo Albini;Mariella Mella;Mauro Freccero

  • More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand.

    Michela Zuffo;Aurore Guédin;Emma-Dune Leriche;Filippo Doria

  • Hybrid ligand–alkylating agents targeting telomeric G-quadruplex structures

    Filippo Doria;Matteo Nadai;Marco Folini;Marco Di Antonio

  • An Aggregating Amphiphilic Squaraine: A Light-up Probe That Discriminates Parallel G-Quadruplexes.

    Vincenzo Grande;Filippo Doria;Mauro Freccero;Frank Würthner

  • Water-soluble naphthalene diimides as singlet oxygen sensitizers.

    Filippo Doria;Ilse Manet;Vincenzo Grande;Sandra Monti

  • Oxidative Functionalization of Adamantane and Some of Its Derivatives in Solution

    M. Mella;M. Freccero;T. Soldi;and E. Fasani

  • Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex.

    Matteo Nadai;Filippo Doria;Marco Di Antonio;Giovanna Sattin

  • Homolytic vs Heterolytic Paths in the Photochemistry of Haloanilines

    Mauro Freccero;Maurizio Fagnoni;Angelo Albini

  • Targeting loop adenines in G-quadruplex by a selective oxirane.

    Filippo Doria;Matteo Nadai;Marco Folini;Matteo Scalabrin

  • BINOL-amino acid conjugates as triggerable carriers of DNA-targeted potent photocytotoxic agents.

    Filippo Doria;Sara N. Richter;Matteo Nadai;Stefano Colloredo-Mels

Frequent Co-Authors

Angelo Albini
Angelo Albini University of Pavia
Maurizio Fagnoni
Maurizio Fagnoni University of Pavia
Nadia Zaffaroni
Nadia Zaffaroni University of Milan
Stefano Alcaro
Stefano Alcaro Magna Graecia University
Paola Barraja
Paola Barraja University of Palermo
Piercarlo Mustarelli
Piercarlo Mustarelli University of Milano-Bicocca
Girolamo Cirrincione
Girolamo Cirrincione University of Palermo
Marie-Paule Teulade-Fichou
Marie-Paule Teulade-Fichou University of Paris-Saclay
Cristiana Di Valentin
Cristiana Di Valentin University of Milano-Bicocca

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