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Biology and Biochemistry
UK
2026

D-Index & Metrics

Chemistry

D-Index
114
Citations
52297
World Ranking
659
National Ranking
32

Biology and Biochemistry

D-Index
114
Citations
53997
World Ranking
826
National Ranking
45

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

Stephen Neidle is affiliated with University College London in the United Kingdom. Their research is mainly concentrated within the field of Biochemistry, Genetics and Molecular Biology, publishing extensively in Molecular Biology with additional contributions in Organic Chemistry, Ecology, Genetics, and Developmental and Educational Psychology.

Their work covers a range of scientific topics, including:

  • DNA and Nucleic Acid Chemistry
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • RNA and protein synthesis mechanisms
  • Bacteriophages and microbial interactions
  • Click Chemistry and Applications
  • RNA modifications and cancer

Stephen Neidle has published papers in a variety of venues, frequently contributing to:

  • Cancer Research
  • Nucleic Acids Research
  • Molecules
  • ACS Medicinal Chemistry Letters
  • Scientific Reports

Some recent papers authored or co-authored by Stephen Neidle include:

  • Beyond the double helix: DNA structural diversity and the PDB, 2021, Journal of Biological Chemistry
  • Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models, 2020, ACS Medicinal Chemistry Letters
  • Water spines and networks in G-quadruplex structures, 2020, Nucleic Acids Research
  • A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells, 2020, Scientific Reports
  • Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology, 2020, ACS Medicinal Chemistry Letters

Their frequent co-authors include Tariq Arshad, Ahmed A. Ahmed, Mark R. Sanderson, Ahmed Ahmed, and Jenny Worthington. Collaboration across these co-authors reflects ongoing research partnerships in their field of study.

Best Publications

  • Quadruplex DNA: sequence, topology and structure

    Sarah Burge;Gary N. Parkinson;Pascale Hazel;Alan K. Todd

  • Crystal structure of parallel quadruplexes from human telomeric DNA.

    Gary N. Parkinson;Michael P. H. Lee;Stephen Neidle

  • Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

    Shankar Balasubramanian;Laurence H. Hurley;Stephen Neidle

  • Highly prevalent putative quadruplex sequence motifs in human DNA

    Alan K. Todd;Matthew Johnston;Stephen Neidle

  • Inhibition of human telomerase by a G-quadruplex-interactive compound.

    Daekyu Sun;Brian Thompson;Brian E. Cathers;Miguel Salazar

  • Telomere maintenance as a target for anticancer drug discovery.

    Stephen Neidle;Gary Parkinson

  • A standard reference frame for the description of nucleic acid base-pair geometry

    Wilma K Olson;Manju Bansal;Stephen K Burley;Richard E Dickerson

  • Quadruplex Nucleic Acids as Novel Therapeutic Targets.

    Stephen Neidle

  • The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

    Angelika M. Burger;Fangping Dai;Christoph M. Schultes;Anthony P. Reszka

  • Putative DNA Quadruplex Formation within the Human c-kit Oncogene

    Sarah Rankin;Anthony P. Reszka;Julian Huppert;Mire Zloh

  • Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer.

    Stephen Neidle

  • G-quadruplex nucleic acids as therapeutic targets

    Shankar Balasubramanian;Stephen Neidle

  • DNA minor-groove recognition by small molecules

    Stephen Neidle

  • Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors

    M Read;RJ Harrison;B Romagnoli;FA Tanious

  • Loop-length-dependent folding of G-quadruplexes.

    Pascale Hazel;Julian Huppert;Shankar Balasubramanian;Stephen Neidle

  • Quadruplex nucleic acids.

    Stephen Neidle;Shankar Balasubramanian

  • The structure of telomeric DNA

    Stephen Neidle;Gary N Parkinson

  • Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter.

    Anh Tuân Phan;Vitaly Kuryavyi;Sarah Burge;Stephen Neidle

  • Quadruplex nucleic acids as targets for anticancer therapeutics

    Stephen Neidle

  • The structures of quadruplex nucleic acids and their drug complexes.

    Stephen Neidle

  • Principles of nucleic acid structure

    Stephen Neidle

Frequent Co-Authors

Gary N. Parkinson
Gary N. Parkinson University College London
Shankar Balasubramanian
Shankar Balasubramanian University of Cambridge
Charles A. Laughton
Charles A. Laughton University of Nottingham
David E. Thurston
David E. Thurston King's College London
Reiko Kuroda
Reiko Kuroda Chubu University
Lloyd R. Kelland
Lloyd R. Kelland University College London
W. David Wilson
W. David Wilson Georgia State University
Keith R. Fox
Keith R. Fox University of Southampton
Robert McKenna
Robert McKenna University of Florida
David W. Boykin
David W. Boykin Georgia State University

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