D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Microbiology D-index 46 Citations 6,599 168 World Ranking 3832 National Ranking 82

Overview

What is he best known for?

The fields of study Pieter Leyssen is best known for:

  • Virus
  • Enzyme
  • Gene

Pieter Leyssen merges Virus with Rhinovirus in his study. In his articles, Pieter Leyssen combines various disciplines, including Virology and Viral replication. As part of his studies on Viral replication, Pieter Leyssen often connects relevant subjects like Genetics. As part of his studies on Genetics, Pieter Leyssen often connects relevant subjects like Antiviral drug. He conducted interdisciplinary study in his works that combined Biochemistry and Pharmacology. In his works, he conducts interdisciplinary research on Pharmacology and Biochemistry. He merges Gene with Molecular biology in his research. He applies his multidisciplinary studies on Molecular biology and Gene in his research. Pieter Leyssen combines RNA and Polymerase in his research.

His most cited work include:

  • α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment (390 citations)
  • The Predominant Mechanism by Which Ribavirin Exerts Its Antiviral Activity In Vitro against Flaviviruses and Paramyxoviruses Is Mediated by Inhibition of IMP Dehydrogenase (253 citations)
  • Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern (204 citations)

What are the main themes of his work throughout his whole career to date

His work on Virology is being expanded to include thematically relevant topics such as Enterovirus. He carries out multidisciplinary research, doing studies in Biochemistry and Pharmacology. He performs integrative study on Pharmacology and Biochemistry. He integrates many fields, such as Gene and Enzyme, in his works. He brings together Enzyme and Gene to produce work in his papers. He combines topics linked to Genetics with his work on Viral replication. He regularly links together related areas like Viral replication in his Genetics studies. Borrowing concepts from Virus, Pieter Leyssen weaves in ideas under In vitro. Stereochemistry and Organic chemistry are two areas of study in which Pieter Leyssen engages in interdisciplinary research.

Pieter Leyssen most often published in these fields:

  • Virology (84.62%)
  • Virus (80.77%)
  • Biochemistry (62.18%)

What were the highlights of his more recent work (between 2020-2022)?

  • Virology (100.00%)
  • Virus (78.57%)
  • Disease (64.29%)

In recent works Pieter Leyssen was focusing on the following fields of study:

The research on Vero cell, EC50, Potency, Cytotoxic T cell and Cytotoxicity is part of his In vitro project. His study ties his expertise on Virology together with the subject of Vero cell. His Virology study frequently draws connections between related disciplines such as Titer. Cytotoxic T cell is often connected to In vitro in his work. He connects Cytotoxicity with Virus in his study. Pieter Leyssen merges many fields, such as Virus and Viral entry, in his writings. He is investigating Viral life cycle and Viral entry as part of his examination of Viral replication. In his research, Pieter Leyssen performs multidisciplinary study on Viral life cycle and Viral replication. Within the field of Protease and Polymerase Pieter Leyssen studies Enzyme.

Between 2020 and 2022, his most popular works were:

  • Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern (204 citations)
  • The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model (70 citations)
  • Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen (64 citations)

In his most recent research, the most cited works focused on:

  • Virus
  • DNA
  • Enzyme

Pieter Leyssen integrates many fields in his works, including Virology and Viral replication. Viral replication and Virology are two areas of study in which he engages in interdisciplinary research. He integrates many fields, such as Biochemistry and Receptor, in his works. He merges Receptor with Biochemistry in his study. His research on In vitro frequently links to adjacent areas such as Vero cell. His Vero cell study typically links adjacent topics like In vitro. Pieter Leyssen integrates several fields in his works, including Virus and Protease. Pieter Leyssen performs integrative Protease and Gene research in his work. In his research, Pieter Leyssen performs multidisciplinary study on Gene and Molecular biology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

Linlin Zhang;Daizong Lin;Yuri Kusov;Yong Nian.
Journal of Medicinal Chemistry (2020)

377 Citations

Perspectives for the Treatment of Infections with Flaviviridae

P Leyssen;E De Clercq;J Neyts.
Clinical Microbiology Reviews (2000)

311 Citations

Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.

Jeroen R.P.M. Strating;Jeroen R.P.M. Strating;Lonneke van der Linden;Lonneke van der Linden;Lucian Albulescu;Lucian Albulescu;Joëlle Bigay.
Cell Reports (2015)

210 Citations

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

Leen Delang;Nidya Segura Guerrero;Ali Tas;Gilles Quérat.
Journal of Antimicrobial Chemotherapy (2014)

205 Citations

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation

Louis-Félix Nothias;Louis-Félix Nothias;Louis-Félix Nothias;Mélissa Nothias-Esposito;Mélissa Nothias-Esposito;Ricardo da Silva;Ricardo da Silva;Mingxun Wang;Mingxun Wang.
Journal of Natural Products (2018)

199 Citations

Molecular strategies to inhibit the replication of RNA viruses

Pieter Leyssen;Erik De Clercq;Johan Neyts.
Antiviral Research (2008)

185 Citations

Poly(I)-Poly(C12U) but Not Ribavirin Prevents Death in a Hamster Model of Nipah Virus Infection

M. C. Georges-Courbot;H. Contamin;C. Faure;P. Loth.
Antimicrobial Agents and Chemotherapy (2006)

136 Citations

Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development.

Leen Delang;Jan Paeshuyse;Inge Vliegen;Pieter Leyssen.
Hepatology (2009)

129 Citations

Favipiravir (T-705) inhibits in vitro norovirus replication.

J Rocha-Pereira;Dirk Jochmans;Kai Dallmeier;Pieter Leyssen.
Biochemical and Biophysical Research Communications (2012)

121 Citations

A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ

Hilde M van der Schaar;Pieter Leyssen;Hendrik Jan Thibaut;Armando De Palma.
Antimicrobial Agents and Chemotherapy (2013)

111 Citations

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