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Microbiology

D-Index
57
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11077
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3592
National Ranking
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Overview

Pieter Leyssen is affiliated with the Rega Institute for Medical Research in Belgium. Their research primarily focuses on medicine, with a significant contribution to infectious diseases, epidemiology, molecular biology, computational theory and mathematics, and public health, environmental and occupational health.

The main topics of Pieter Leyssen's work include:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Computational Drug Discovery Methods
  • Viral Infections and Immunology Research
  • Mosquito-borne diseases and control
  • Viral gastroenteritis research and epidemiology
  • Animal Virus Infections Studies

Frequently publishing in scientific venues, Pieter Leyssen's work appears often in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Antiviral Research
  • Molecules
  • Nature Communications
  • Journal of Medicinal Chemistry

The scientist has collaborated multiple times with several coauthors, including:

  • Johan Neyts
  • Dirk Jochmans
  • Steven De Jonghe
  • Laura Vangeel
  • Winston Chiu

Pieter Leyssen's notable recent publications are:

  • "α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment," 2020, Journal of Medicinal Chemistry
  • "Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern," 2022, Antiviral Research
  • "STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters," 2020, Nature Communications
  • "Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen," 2021, ACS Pharmacology & Translational Science
  • "The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model," 2021, EBioMedicine

Best Publications

  • Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

    Unknown

  • α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

    Linlin Zhang;Daizong Lin;Yuri Kusov;Yong Nian

  • Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation

    Louis-Félix Nothias;Louis-Félix Nothias;Louis-Félix Nothias;Mélissa Nothias-Esposito;Mélissa Nothias-Esposito;Ricardo da Silva;Ricardo da Silva;Mingxun Wang;Mingxun Wang

  • The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase.

    Pieter Leyssen;Jan Balzarini;Erik De Clercq;Johan Neyts

  • Perspectives for the Treatment of Infections with Flaviviridae

    P Leyssen;E De Clercq;J Neyts

  • STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.

    Robbert Boudewijns;Robbert Boudewijns;Hendrik Jan Thibaut;Hendrik Jan Thibaut;Suzanne J. F. Kaptein;Suzanne J. F. Kaptein;Rong Li

  • Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.

    Jeroen R.P.M. Strating;Jeroen R.P.M. Strating;Lonneke van der Linden;Lonneke van der Linden;Lucian Albulescu;Lucian Albulescu;Joëlle Bigay

  • Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

    Leen Delang;Nidya Segura Guerrero;Ali Tas;Gilles Quérat

  • Molecular strategies to inhibit the replication of RNA viruses

    Pieter Leyssen;Erik De Clercq;Johan Neyts

  • Poly(I)-Poly(C12U) but Not Ribavirin Prevents Death in a Hamster Model of Nipah Virus Infection

    M. C. Georges-Courbot;H. Contamin;C. Faure;P. Loth

  • Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

    Maria Kuzikov;Elisa Costanzi;Jeanette Reinshagen;Francesca Esposito

  • Favipiravir (T-705) inhibits in vitro norovirus replication.

    J Rocha-Pereira;Dirk Jochmans;Kai Dallmeier;Pieter Leyssen

  • A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ

    Hilde M van der Schaar;Pieter Leyssen;Hendrik Jan Thibaut;Armando De Palma

  • 3C protease of enterovirus 68: Structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses

    Jinzhi Tan;Shyla George;Yuri Kusov;Markus Perbandt

  • The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model.

    Rana Abdelnabi;Caroline S. Foo;Suzanne J.F. Kaptein;Xin Zhang

  • Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development.

    Leen Delang;Jan Paeshuyse;Inge Vliegen;Pieter Leyssen

  • Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus

    Marcella Bassetto;Tine De Burghgraeve;Leen Delang;Alberto Massarotti

  • Novel 1,2,4-triazole and imidazole derivatives of l-ascorbic and imino-ascorbic acid: Synthesis, anti-HCV and antitumor activity evaluations

    Karlo Wittine;Maja Stipković Babić;Damjan Makuc;Janez Plavec

  • The anti-yellow fever virus activity of ribavirin is independent of error-prone replication.

    Pieter Leyssen;Erik De Clercq;Johan Neyts

  • Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus.

    Jih Ru Hwu;Jih Ru Hwu;Shu-Yu Lin;Shwu-Chen Tsay;Erik De Clercq

  • Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication.

    Mélanie Bourjot;Leen Delang;Van Hung Nguyen;Johan Neyts

Frequent Co-Authors

Johan Neyts
Johan Neyts Rega Institute for Medical Research
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Bruno Canard
Bruno Canard Aix-Marseille University
Françoise Guéritte
Françoise Guéritte Institut de Chimie des Substances Naturelles
Christophe Pannecouque
Christophe Pannecouque Rega Institute for Medical Research
Frank J. M. van Kuppeveld
Frank J. M. van Kuppeveld Utrecht University
Bruno Coutard
Bruno Coutard Aix-Marseille University
Jan Balzarini
Jan Balzarini KU Leuven
Jih Ru Hwu
Jih Ru Hwu National Tsing Hua University

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