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Jih Ru Hwu

Jih Ru Hwu

National Tsing Hua University
Taiwan

Research.com Recognitions

Awards & Achievements

1999 - Fellow, The World Academy of Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • Organic chemistry
  • Enzyme
  • Catalysis

Jih Ru Hwu spends much of his time researching Organic chemistry, Stereochemistry, Medicinal chemistry, Selectivity and Hepatitis C virus. Jih Ru Hwu does research in Stereochemistry, focusing on Bicyclic molecule specifically. His Medicinal chemistry research is multidisciplinary, relying on both Divinylbenzene, Catalysis, Silylation and Blue light.

His Selectivity research integrates issues from Ring, Metal ions in aqueous solution and Adsorption. His Hepatitis C virus study combines topics from a wide range of disciplines, such as Conjugated system, Viral replication, Coumarin and Benzimidazole. As part of the same scientific family, Jih Ru Hwu usually focuses on Benzimidazole, concentrating on Anti hiv and intersecting with Virus.

His most cited work include:

  • Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles. (153 citations)
  • Structure-activity relationship of new anti-hepatitis C virus agents: heterobicycle-coumarin conjugates. (146 citations)
  • Efficient one-flask synthesis of water-soluble [60]fullerenols (136 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Organic chemistry, Stereochemistry, Medicinal chemistry, Photochemistry and Moiety. His study in Reagent, Aliphatic compound, Catalysis, Ceric ammonium nitrate and Sodium is carried out as part of his studies in Organic chemistry. His studies in Stereochemistry integrate themes in fields like Biological activity, Aryne and Coumarin.

His research integrates issues of Adduct, Nitro, Electronic effect and Silylation in his study of Medicinal chemistry. His Photochemistry study integrates concerns from other disciplines, such as Dna cleavage, Cleavage, DNA and Silicon. His Moiety study incorporates themes from Combinatorial chemistry, Carbanion and Alkylation.

He most often published in these fields:

  • Organic chemistry (35.43%)
  • Stereochemistry (32.66%)
  • Medicinal chemistry (28.39%)

What were the highlights of his more recent work (between 2009-2021)?

  • Stereochemistry (32.66%)
  • Aryne (6.78%)
  • Total synthesis (7.29%)

In recent papers he was focusing on the following fields of study:

Jih Ru Hwu focuses on Stereochemistry, Aryne, Total synthesis, Moiety and Virus. The Stereochemistry study combines topics in areas such as Conjugated system, Biological activity, Molecule and Coumarin. In his study, Medicinal chemistry is inextricably linked to PLGA, which falls within the broad field of Biological activity.

Jih Ru Hwu works mostly in the field of Coumarin, limiting it down to topics relating to Hepatitis C virus and, in certain cases, Selectivity, as a part of the same area of interest. Jih Ru Hwu has researched Aryne in several fields, including Cycloaddition, 1,3-Dipolar cycloaddition, Silicon, Phenanthrene and Photochemistry. His Moiety research is multidisciplinary, incorporating perspectives in Prodrug and Biochemistry.

Between 2009 and 2021, his most popular works were:

  • Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus. (88 citations)
  • Visible-light initiated copper(I)-catalysed oxidative C–N coupling of anilines with terminal alkynes: one-step synthesis of α-ketoamides (77 citations)
  • Suramin inhibits chikungunya virus replication through multiple mechanisms. (57 citations)

In his most recent research, the most cited papers focused on:

  • Organic chemistry
  • Enzyme
  • Catalysis

His primary areas of study are Stereochemistry, Coumarin, Virus, Selectivity and Chikungunya. The various areas that Jih Ru Hwu examines in his Stereochemistry study include Conjugated system and 1,3-Dipolar cycloaddition. His Conjugated system study also includes fields such as

  • Molecule and Ring most often made with reference to Binding constant,
  • Structure–activity relationship, which have a strong connection to RNA-dependent RNA polymerase, IC50, RNA polymerase and Suramin.

His Coumarin research includes themes of Ribavirin, Hepacivirus, Hepatitis C virus and Purine. His study of Viral replication is a part of Virus. His studies in Selectivity integrate themes in fields like Inorganic chemistry, Metal ions in aqueous solution and Adsorption.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles.

Jih Ru Hwu;Yu Sern Lin;Thainashmuthu Josephrajan;Ming-Hua Hsu.
Journal of the American Chemical Society (2009)

221 Citations

Efficient one-flask synthesis of water-soluble [60]fullerenols

Long Y. Chiang;J.B. Bhonsle;Leeyih Wang;S.F. Shu.
Tetrahedron (1996)

208 Citations

Synthesis of new benzimidazole-coumarin conjugates as anti-hepatitis C virus agents.

Jih Ru Hwu;Raghunath Singha;Shih Ching Hong;Yung Hsiung Chang.
Antiviral Research (2008)

203 Citations

Structure-activity relationship of new anti-hepatitis C virus agents: heterobicycle-coumarin conjugates.

Johan Neyts;Erik De Clercq;Raghunath Singha;Yung Hsiung Chang.
Journal of Medicinal Chemistry (2009)

194 Citations

Antiviral Activities of Methylated Nordihydroguaiaretic Acids. 1. Synthesis, Structure Identification, and Inhibition of Tat-Regulated HIV Transactivation

Jih Ru Hwu;Wen Nan Tseng;John Gnabre;Paul Giza.
Journal of Medicinal Chemistry (1998)

134 Citations

Visible-light initiated copper(I)-catalysed oxidative C–N coupling of anilines with terminal alkynes: one-step synthesis of α-ketoamides

Arunachalam Sagadevan;Ayyakkannu Ragupathi;Chun-Cheng Lin;Jih Ru Hwu.
Green Chemistry (2015)

116 Citations

Fabrication of oriented antibody-conjugated magnetic nanoprobes and their immunoaffinity application.

Po-Chiao Lin;Shu-Hua Chen;Kai-Yi Wang;Mu-Lin Chen.
Analytical Chemistry (2009)

108 Citations

Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus.

Jih Ru Hwu;Jih Ru Hwu;Shu-Yu Lin;Shwu-Chen Tsay;Erik De Clercq.
Journal of Medicinal Chemistry (2011)

104 Citations

Ceric ammonium nitrate on silica gel for efficient and selective removal of trityl and silyl groups

Jih Ru Hwu;Moti L. Jain;Fu-Yuan Tsai,†,‡;† Shwu-Chen Tsay.
Journal of Organic Chemistry (2000)

97 Citations

Microwave Arcing Induced Formation and Growth Mechanisms of Core/Shell Metal/Carbon Nanoparticles in Organic Solutions

Yu-Lin Hsin;Chia-Fen Lin;Yu-Chia Liang;Kuo Chu Hwang.
Advanced Functional Materials (2008)

93 Citations

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