D-Index & Metrics Best Publications
Microbiology
Belgium
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Microbiology D-index 80 Citations 24,022 265 World Ranking 320 National Ranking 8
Medicine D-index 82 Citations 25,336 297 World Ranking 8564 National Ranking 88

Research.com Recognitions

Awards & Achievements

2022 - Research.com Microbiology in Belgium Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Virus

Dominique Schols spends much of his time researching Virology, Virus, Molecular biology, Chemokine receptor and Biochemistry. The concepts of his Virology study are interwoven with issues in Reverse transcriptase and CXCR4. His Virus research is multidisciplinary, incorporating perspectives in Cell culture, Lectin and In vitro.

His studies in Molecular biology integrate themes in fields like Mutation, T cell, Receptor, CXC chemokine receptors and CC chemokine receptors. His research in Receptor intersects with topics in Cyclam, Monoclonal antibody, Stereochemistry and COS cells. His Chemokine receptor research is multidisciplinary, incorporating elements of Ligand and Cell biology.

His most cited work include:

  • Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds (1426 citations)
  • CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. (851 citations)
  • AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor (687 citations)

What are the main themes of his work throughout his whole career to date?

Dominique Schols mainly focuses on Virology, Virus, Receptor, Stereochemistry and Molecular biology. His studies deal with areas such as Cell culture and In vitro as well as Virology. In his research on the topic of Virus, Lectin is strongly related with Microbiology.

His Receptor study combines topics from a wide range of disciplines, such as Monoclonal antibody and Pharmacology. The Stereochemistry study combines topics in areas such as DNA, IC50, HeLa, Prodrug and Structure–activity relationship. His Molecular biology study frequently intersects with other fields, such as T cell.

He most often published in these fields:

  • Virology (39.70%)
  • Virus (19.70%)
  • Receptor (15.00%)

What were the highlights of his more recent work (between 2014-2021)?

  • Stereochemistry (14.39%)
  • Biochemistry (12.88%)
  • Virus (19.70%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Stereochemistry, Biochemistry, Virus, HeLa and Receptor. His Stereochemistry study incorporates themes from Cell culture, IC50, Nucleotide, DNA and Structure–activity relationship. His Virus research is within the category of Virology.

The various areas that he examines in his HeLa study include Biological activity and Cytotoxicity. His research on Receptor often connects related areas such as Cell biology. His Chemokine receptor study combines topics in areas such as CXCR4 and Ligand.

Between 2014 and 2021, his most popular works were:

  • Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity. (230 citations)
  • The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model. (191 citations)
  • STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters. (51 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Virus

His scientific interests lie mostly in Stereochemistry, Biochemistry, Biological activity, Receptor and Structure–activity relationship. He studies Receptor, namely Chemokine receptor. His Chemokine receptor research integrates issues from Ligand, CXCR4 and Cell biology.

His Structure–activity relationship research incorporates elements of Amino acid, Doxorubicin, Virus, Cytotoxicity and Topoisomerase. The Antibody study which covers Immune system that intersects with Virology. His study in Virology is interdisciplinary in nature, drawing from both IL-2 receptor and Tubercidin.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Rudi Pauwels;Jan Balzarini;Masanori Baba;Robert Snoeck.
Journal of Virological Methods (1988)

2327 Citations

CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity.

Paola Bezzi;Maria Domercq;Liliana Brambilla;Rossella Galli.
Nature Neuroscience (2001)

1070 Citations

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

Rudi Pauwels;Koen Andries;Jan Desmyter;Dominique Schols.
Nature (1990)

1040 Citations

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

G A Donzella;D Schols;S W Lin;J A Esté.
Nature Medicine (1998)

919 Citations

Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4

Dominique Schols;Sofie Struyf;Jo Van Damme;José A. Esté.
Journal of Experimental Medicine (1997)

817 Citations

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

Sigrid Hatse;Katrien Princen;Gary Bridger;Erik De Clercq.
FEBS Letters (2002)

601 Citations

Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.

J Balzarini;A Holy;J Jindrich;L Naesens.
Antimicrobial Agents and Chemotherapy (1993)

440 Citations

Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection

Craig W. Hendrix;Ann C. Collier;Michael Marcel Lederman;Dominique Schols.
Journal of Acquired Immune Deficiency Syndromes (2004)

431 Citations

Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.

Paul Proost;Ingrid De Meester;Dominique Schols;Sofie Struyf.
Journal of Biological Chemistry (1998)

387 Citations

Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.

M. Baba;H. Tanaka;E. De Clercq;R. Pauwels.
Biochemical and Biophysical Research Communications (1989)

380 Citations

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