Dominique Schols

Research.com Recognitions

• 2026 - Research.com Microbiology in Belgium Leader Award
• 2025 - Research.com Microbiology in Belgium Leader Award
• 2023 - Research.com Microbiology in Belgium Leader Award
• 2022 - Research.com Microbiology in Belgium Leader Award

Overview

Best Publications

• Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

  Rudi Pauwels;Jan Balzarini;Masanori Baba;Robert Snoeck

  2575
  Citations

• CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity.

  Paola Bezzi;Maria Domercq;Liliana Brambilla;Rossella Galli

  1261
  Citations

• Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

  Rudi Pauwels;Koen Andries;Jan Desmyter;Dominique Schols

  1152
  Citations

• AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

  G A Donzella;D Schols;S W Lin;J A Esté

  994
  Citations

• Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4

  Dominique Schols;Sofie Struyf;Jo Van Damme;José A. Esté

  841
  Citations

• Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity

  Carmela Saturnino;Fedora Grande;Stefano Aquaro;Anna Caruso

  704
  Citations

• Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

  Sigrid Hatse;Katrien Princen;Gary Bridger;Erik De Clercq

  665
  Citations

• Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine.

  J Balzarini;A Holy;J Jindrich;L Naesens

  497
  Citations

• Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection

  Craig W. Hendrix;Ann C. Collier;Michael Marcel Lederman;Dominique Schols

  465
  Citations

• Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.

  Paul Proost;Ingrid De Meester;Dominique Schols;Sofie Struyf

  412
  Citations

• Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.

  M. Baba;H. Tanaka;E. De Clercq;R. Pauwels

  402
  Citations

• AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.

  Patrick Matthys;Sigrid Hatse;Kurt Vermeire;Anja Wuyts

  398
  Citations

• Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents.

  R Pauwels;J Balzarini;D Schols;M Baba

  367
  Citations

• The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model.

  Joanna Zmurko;Rafael E. Marques;Dominique Schols;Erik Verbeken

  366
  Citations

• The Mannose-Specific Plant Lectins From Cymbidium Hybrid and Epipactis Helleborine and the (N-acetylglucosamine)n-specific Plant Lectin From Urtica Dioica Are Potent and Selective Inhibitors of Human Immunodeficiency Virus and Cytomegalovirus Replication in Vitro

  J Balzarini;J Neyts;D Schols;M Hosoya

  341
  Citations

• Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4.

  Dominique Schols;José A Esté;Geoffrey Henson;Erik De Clercq

  340
  Citations

• Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

  E De Clercq;N Yamamoto;R Pauwels;M Baba

  339
  Citations

• Macrophage Tropism of Human Immunodeficiency Virus Type 1 Isolates from Brain and Lymphoid Tissues Predicts Neurotropism Independent of Coreceptor Specificity

  Paul R. Gorry;Greg Bristol;Jerome A. Zack;Kimberly Ritola

  338
  Citations

• Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro.

  J Balzarini;D Schols;J Neyts;E Van Damme

  329
  Citations

• AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity.

  Nicholas W. Lukacs;Aaron Berlin;Dominique Schols;Renato T. Skerlj

  319
  Citations

• Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1.

  Dominique Schols;Rudi Pauwels;Jan Desmyter;Erik De Clercq

  315
  Citations