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Zeger Debyser

Zeger Debyser

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Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
84
Citations
23311
World Ranking
3353
National Ranking
54

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award

Overview

Zeger Debyser is affiliated with KU Leuven in Belgium and has a research focus spanning several areas within biomedical sciences. Their work encompasses multiple main fields of study including Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Within these fields, Debyser's subfields include Molecular Biology, Virology, Infectious Diseases, Genetics, and Pulmonary and Respiratory Medicine.

The scientist's research contributions concentrate on a range of topics related to viral infections and molecular mechanisms, with a strong emphasis on HIV research and treatment. Key topics of their work include:

  • HIV Research and Treatment
  • HIV/AIDS drug development and treatment
  • Protein Degradation and Inhibitors
  • Cytomegalovirus and herpesvirus research
  • Virus-based gene therapy research
  • Genetics and Neurodevelopmental Disorders
  • RNA Interference and Gene Delivery

Zeger Debyser has co-authored frequently with several researchers, including:

  • Frauke Christ
  • Siska Van Belle
  • Rik Gijsbers
  • Anne Bruggemans
  • Jan De Rijck

Debyser's recent papers reflect ongoing research themes in virology and molecular biology. Notable publications include:

  • Block-And-Lock Strategies to Cure HIV Infection, 2020, Viruses
  • The chromatin landscape at the HIV-1 provirus integration site determines viral expression, 2020, Nucleic Acids Research
  • A ubiquitous disordered protein interaction module orchestrates transcription elongation, 2021, Science
  • Capsid-Labelled HIV To Investigate the Role of Capsid during Nuclear Import and Integration, 2020, Journal of Virology
  • Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells, 2024, Cell Reports Medicine

The publication venues frequented by Debyser include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Viruses
  • Cells
  • SSRN Electronic Journal
  • Nucleic Acids Research

Best Publications

  • HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

    Peter Cherepanov;Goedele Maertens;Paul Proost;Bart Devreese

  • LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells

    Goedele Maertens;Peter Cherepanov;Willem Pluymers;Katrien Busschots

  • Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

    Frauke Christ;Arnout Voet;Arnaud Marchand;Stefan Nicolet;Stefan Nicolet

  • Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100.

    E De Clercq;N Yamamoto;R Pauwels;J Balzarini

  • Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-Associated Viral Vectors at Scale

    Martin Lock;Mauricio Alvira;Luk H. Vandenberghe;Arabinda Samanta

  • Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain.

    Jean-Marc Taymans;Luk H Vandenberghe;Chris Van Den Haute;Irina Thiry

  • Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

    E De Clercq;N Yamamoto;R Pauwels;M Baba

  • Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication.

    Stéphane Emiliani;Aurélie Mousnier;Katrien Busschots;Marlène Maroun

  • Transportin-SR2 Imports HIV into the Nucleus

    Frauke Christ;Wannes Thys;Jan De Rijck;Rik Gijsbers

  • The Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding

    Katrien Busschots;Jo Vercammen;Stéphane Emiliani;Richard Benarous

  • Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus.

    Linos Vandekerckhove;Frauke Christ;Bénédicte Van Maele;Jan De Rijck

  • Cellular co-factors of HIV-1 integration.

    Bénédicte Van Maele;Katrien Busschots;Linos Vandekerckhove;Frauke Christ

  • Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

    R Pauwels;K Andries;Z Debyser;P Van Daele

  • Chicoric acid analogues as HIV-1 integrase inhibitors.

    Zhaiwei Lin;Nouri Neamati;He Zhao;Yoshimitsu Kiryu

  • Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.

    Myriam Witvrouw;Valery Fikkert;Wim Pluymers;Barry Matthews

  • An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives.

    Z. Debyser;R. Pauwels;K. Andries;J. Desmyter

  • Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

    Bavo Heeman;Chris Van den Haute;Sarah-Ann Aelvoet;Federica Valsecchi

  • Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication

    Jan De Rijck;Linos Vandekerckhove;Rik Gijsbers;Anneleen Hombrouck

  • Comparison of lentiviral vector titration methods.

    Martine Geraerts;Sofie Willems;Veerle Baekelandt;Zeger Debyser

  • Upscaling of lentiviral vector production by tangential flow filtration

    Martine Geraerts;Martine Michiels;Veerle Baekelandt;Zeger Debyser

Frequent Co-Authors

Frauke Christ
Frauke Christ KU Leuven
Rik Gijsbers
Rik Gijsbers KU Leuven
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Christophe Pannecouque
Christophe Pannecouque Rega Institute for Medical Research
Jan Deprest
Jan Deprest KU Leuven

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