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Rik Gijsbers

Rik Gijsbers

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
8660
World Ranking
15263
National Ranking
266

Overview

Rik Gijsbers is affiliated with KU Leuven in Belgium. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with focused subfields including Molecular Biology, Pathology and Forensic Medicine, Genetics, Virology, and Immunology.

The scientist has contributed to various topics within biomedical research, notably:

  • CRISPR and Genetic Engineering
  • Virus-based gene therapy research
  • Biomedical Research and Pathophysiology
  • HIV Research and Treatment
  • RNA Interference and Gene Delivery
  • Neonatal Health and Biochemistry
  • Amino Acid Enzymes and Metabolism

Rik Gijsbers has published frequently in several scientific venues. The top publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Journal of the American Society of Nephrology
  • Cells
  • Molecular Therapy

Recent papers authored or co-authored by Rik Gijsbers include:

  • Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency, 2020, Journal of Clinical Investigation
  • Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles, 2020, Cell Reports
  • Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells, 2024, Cell Reports Medicine
  • Baboon Envelope Pseudotyped "Nanoblades" Carrying Cas9/gRNA Complexes Allow Efficient Genome Editing in Human T, B, and CD34+ Cells and Knock-in of AAV6-Encoded Donor DNA in CD34+ Cells, 2021, Frontiers in Genome Editing
  • Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning, 2021, Molecular Therapy

Frequent collaborative partners include:

  • Zeger Debyser
  • Elena Levtchenko
  • Maurilio Sampaolesi
  • Frauke Christ
  • Rik Schrijvers

Best Publications

  • Nucleotide Pyrophosphatases/Phosphodiesterases on the Move

    Mathieu Bollen;Rik Gijsbers;Hugo Ceulemans;Willy Stalmans

  • Transportin-SR2 Imports HIV into the Nucleus

    Frauke Christ;Wannes Thys;Jan De Rijck;Rik Gijsbers

  • Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus.

    Linos Vandekerckhove;Frauke Christ;Bénédicte Van Maele;Jan De Rijck

  • Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases.

    Rik Gijsbers;Hugo Ceulemans;Willy Stalmans;Mathieu Bollen

  • Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication

    Jan De Rijck;Linos Vandekerckhove;Rik Gijsbers;Anneleen Hombrouck

  • Comparison of lentiviral vector titration methods.

    Martine Geraerts;Sofie Willems;Veerle Baekelandt;Zeger Debyser

  • Upscaling of lentiviral vector production by tangential flow filtration

    Martine Geraerts;Martine Michiels;Veerle Baekelandt;Zeger Debyser

  • Highly efficient multicistronic lentiviral vectors with peptide 2A sequences.

    Abdelilah Ibrahimi;Greetje Vande Velde;Veerle Reumers;Jaan Toelen

  • The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites

    Jan De Rijck;Christine de Kogel;Jonas Demeulemeester;Sofie Vets

  • LEDGF Hybrids Efficiently Retarget Lentiviral Integration Into Heterochromatin

    Rik Gijsbers;Keshet Ronen;Sofie Vets;Nirav Malani

  • Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines

    Nicholas Hernandez;Giorgia Bucciol;Leen Moens;Jérémie Le Pen

  • Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

    Anneleen Hombrouck;Jan De Rijck;Jelle Hendrix;Linos Vandekerckhove

  • State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations.

    Katia Pauwels;Rik Gijsbers;Jaan Toelen;Axel Schambach

  • LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

    Belete Ayele Desimmie;Rik Schrijvers;Jonas Demeulemeester;Doortje Borrenberghs

  • The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site

    Rik Gijsbers;Junken Aoki;Hiroyuki Arai;Mathieu Bollen

  • LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

    Rik Schrijvers;Jan De Rijck;Jonas Demeulemeester;Noritaka Adachi

  • Parkin Protects against Neurotoxicity in the 6-Hydroxydopamine Rat Model for Parkinson's Disease

    Linda Vercammen;Anke Van der Perren;Elisabetta Vaudano;Rik Gijsbers

  • Size and affinity kinetics of nanobodies influence targeting and penetration of solid tumours

    Pieterjan Debie;Chrystel Lafont;Michel Defrise;Inge Hansen

  • Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZ

    Koen Bartholomeeusen;Frauke Christ;Jelle Hendrix;Jean-Christophe Rain

  • Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

    Koen Bartholomeeusen;Jan De Rijck;Katrien Busschots;Linda Desender

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