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Biology and Biochemistry

D-Index
48
Citations
6856
World Ranking
18486
National Ranking
7545

Overview

Mamuka Kvaratskhelia is a researcher affiliated with the University of Colorado Denver in the United States. Their work primarily focuses on topics related to HIV research and treatment, alongside biochemical and molecular biology investigations. Their academic contributions span several fields, including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology.

The scientist's research delves into subfields such as Virology, Infectious Diseases, and Molecular Biology. Key topics within their study include HIV/AIDS drug development and treatment, biochemical and molecular research, bacteriophages and microbial interactions, cytomegalovirus and herpesvirus research, CRISPR and genetic engineering, and RNA research and splicing.

Their recent papers demonstrate active involvement in advancing understanding of viral mechanisms and host interactions. Notable publications include:

  • Structural and mechanistic bases for a potent HIV-1 capsid inhibitor (2020, Science)
  • Sec24C is an HIV-1 host dependency factor crucial for virus replication (2021, Nature Microbiology)
  • Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection (2022, Nature Communications)
  • Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis (2020, eLife)
  • Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir (2022, mBio)

Kvaratskhelia's frequent collaborators provide a network of co-authorship reflecting shared research interests. These include:

  • Alan Engelman
  • Arun S. Annamalai
  • Lorenzo Briganti
  • Reed Haney
  • Szu-Wei Huang

Their publications are often featured in leading scientific venues, with multiple contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • mBio
  • PLoS Pathogens
  • Nature Communications
  • Viruses

The scope of research undertaken by Mamuka Kvaratskhelia integrates complex virus-host interactions at the molecular level, contributing both to academic knowledge and potential therapeutic approaches within infectious disease fields.

Best Publications

  • Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.

    Kellie A. Jurado;Hao Wang;Alison Slaughter;Lei Feng

  • Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

    Jocelyn O. Eidahl;Brandon L. Crowe;Justin A. North;Christopher J. McKee

  • Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

    Stephanie M. Bester;Guochao Wei;Haiyan Zhao;Daniel Adu-Ampratwum

  • BET proteins promote efficient murine leukemia virus integration at transcription start sites

    Amit Sharma;Ross C. Larue;Matthew R. Plumb;Nirav Malani

  • Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.

    Jacques J. Kessl;Nivedita Jena;Yasuhiro Koh;Humeyra Taskent-Sezgin

  • Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome.

    Dario Oliveira Passos;Min Li;Renbin Yang;Stephanie V. Rebensburg

  • Purification and Characterization of a Novel Class III Peroxidase Isoenzyme from Tea Leaves

    M. Kvaratskhelia;C. Winkel;R. N. F. Thorneley

  • Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

    Christophe Marchand;Krzysztof Krajewski;Hsiu-Fang Lee;Smitha Antony

  • Interactions of HIV-1 Gag with assembly cofactors.

    Nick Shkriabai;Siddhartha A. K. Datta;Zhuojun Zhao;Sonja Hess

  • Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch.

    Siddhartha A.K. Datta;Zhuojun Zhao;Patrick K. Clark;Sergey Tarasov

  • Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein.

    Christopher J. McKee;Jacques J. Kessl;Nikolozi Shkriabai;Mohd Jamal Dar

  • Molecular mechanisms of retroviral integration site selection

    Mamuka Kvaratskhelia;Amit Sharma;Ross C. Larue;Erik Serrao

  • HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis

    Jacques J. Kessl;Sebla B. Kutluay;Sebla B. Kutluay;Dana Townsend;Stephanie Rebensburg

  • The two analogous phosphoglycerate mutases of Escherichia coli

    Heather I Fraser;Mamuka Kvaratskhelia;Malcolm F White

  • Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

    Melissa Kane;Stephanie V Rebensburg;Matthew A Takata;Trinity M Zang;Trinity M Zang

  • A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase

    Amit Sharma;Alison Slaughter;Nivedita Jena;Lei Feng

  • LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

    Parmit Kumar Singh;Matthew R. Plumb;Andrea L. Ferris;James R. Iben

  • HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

    Hao Wang;Kellie Ann Jurado;Xiaolin Wu;Ming-Chieh Shun

  • The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.

    Lei Feng;Amit Sharma;Alison Slaughter;Nivedita Jena

  • Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A

    Steven M. Shell;Zhengke Li;Nikolozi Shkriabai;Mamuka Kvaratskhelia

Frequent Co-Authors

Alan Engelman
Alan Engelman Harvard University
James R. Fuchs
James R. Fuchs The Ohio State University
Sonja Hess
Sonja Hess AstraZeneca (United Kingdom)
Malcolm F. White
Malcolm F. White University of St Andrews
Ronald M. Levy
Ronald M. Levy Temple University
Li Wu
Li Wu University of Iowa
Eric M. Poeschla
Eric M. Poeschla University of Colorado Anschutz Medical Campus
Frederic D. Bushman
Frederic D. Bushman University of Pennsylvania
Paul D. Bieniasz
Paul D. Bieniasz Rockefeller University
Robert Craigie
Robert Craigie National Institutes of Health

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