2023 - Research.com Biology and Biochemistry in Canada Leader Award
Stephen H. Hughes mostly deals with Reverse transcriptase, Molecular biology, Virology, Polymerase and DNA. His Reverse transcriptase research integrates issues from Enzyme, Mutant, Binding site and Primer. His research integrates issues of Mutation, Complementary DNA, RNA-Directed DNA Polymerase and Nuclear transport, Cell nucleus in his study of Molecular biology.
The study incorporates disciplines such as Genetics and Drug resistance in addition to Virology. His work carried out in the field of Polymerase brings together such families of science as Protein structure, Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors and Active site. His DNA research is multidisciplinary, incorporating elements of RNA and Ternary complex.
The scientist’s investigation covers issues in Quantum dot, Reverse transcriptase, Molecular biology, Virology and Photon. His Quantum dot research incorporates themes from Master equation, Condensed matter physics, Quantum optics and Photonic crystal. His work is dedicated to discovering how Reverse transcriptase, Polymerase are connected with Active site and other disciplines.
His Molecular biology study combines topics in areas such as Plasmid, Mutation, Mutant, Murine leukemia virus and Gene. The Virology study combines topics in areas such as Integrase, Vector and Drug resistance. Stephen H. Hughes interconnects Plasmon, Dipole, Molecular physics, Quantum and Cavity quantum electrodynamics in the investigation of issues within Photon.
Stephen H. Hughes mainly investigates Quantum, Virology, Quantum dot, Photon and Quantum electrodynamics. His Quantum study combines topics from a wide range of disciplines, such as Plasmon, Quantum optics and Gauge theory. He has researched Virology in several fields, including RNA, Peripheral blood mononuclear cell, Drug resistance and Provirus.
His RNA research focuses on subjects like Virus, which are linked to Gene, Integrase and Reverse transcriptase. His Quantum dot study incorporates themes from Optics, Master equation, Molecular physics, Excitation and Atomic physics. The concepts of his Photon study are interwoven with issues in Nanowire, Computational physics and Dephasing.
His main research concerns Quantum, Virology, Photon, Resonator and Quantum dot. His Quantum research is multidisciplinary, incorporating perspectives in Field and Quantum optics. In the field of Virology, his study on Virus overlaps with subjects such as 2019-20 coronavirus outbreak.
His work focuses on many connections between Photon and other disciplines, such as Quantum electrodynamics, that overlap with his field of interest in Observable, Operator, Electric field and Resonance. His studies in Resonator integrate themes in fields like Quantum mechanics and Dissipative system. His research in Quantum dot intersects with topics in Master equation and Dephasing.
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A Human Oncogene Formed by the Fusion of Truncated Tropomyosin and Protein Tyrosine Kinase Sequences
Dionisio Martin-Zanca;Stephen H. Hughes;Mariano Barbacid.
The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.
Yoel Kashman;Kirk R. Gustafson;Richard W. Fuller;John H. Cardellina.
Journal of Medicinal Chemistry (1992)
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.
Stefan G. Sarafianos;Bruno Marchand;Kalyan Das;Daniel M. Himmel.
Journal of Molecular Biology (2009)
Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance
Chris Tantillo;Jianping Ding;Alfredo Jacobo-Molina;Raymond G. Nanni.
Journal of Molecular Biology (1994)
Extrinsic optical scattering loss in photonic crystal waveguides: role of fabrication disorder and photon group velocity.
S. Hughes;L. Ramunno;Jeff F. Young;J. E. Sipe.
Physical Review Letters (2005)
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.
Stefan G. Sarafianos;Kalyan Das;Chris Tantillo;Arthur D. Clark.
The EMBO Journal (2001)
Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles.
Thomas Roth;Marshall L. Morningstar;Paul L. Boyer;Stephen H. Hughes.
Journal of Medicinal Chemistry (1997)
Flexible Use of Nuclear Import Pathways by HIV-1
KyeongEun Lee;Zandrea Ambrose;Thomas D. Martin;Ilker Oztop.
Cell Host & Microbe (2010)
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).
Paul A. J. Janssen;Paul J. Lewi;Eddy Arnold;Frits Daeyaert.
Journal of Medicinal Chemistry (2005)
B-108 Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
Frank Maldarelli;Xiaolin Wu;Ling Su;Francesco Simonetti.
Journal of Acquired Immune Deficiency Syndromes (2016)
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