Stephen Hughes

Overview

Best Publications

• A Human Oncogene Formed by the Fusion of Truncated Tropomyosin and Protein Tyrosine Kinase Sequences

  Dionisio Martin-Zanca;Stephen H. Hughes;Mariano Barbacid

  982
  Citations

• Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

  F. Maldarelli;X. Wu;L. Su;F. R. Simonetti

  955
  Citations

• Reprogramming human T cell function and specificity with non-viral genome targeting

  Theodore L. Roth;Cristina Puig-Saus;Ruby Yu;Ruby Yu;Eric Shifrut;Eric Shifrut

  846
  Citations

• The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.

  Yoel Kashman;Kirk R. Gustafson;Richard W. Fuller;John H. Cardellina

  826
  Citations

• Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.

  Stefan G. Sarafianos;Bruno Marchand;Kalyan Das;Daniel M. Himmel

  676
  Citations

• Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance

  Chris Tantillo;Jianping Ding;Alfredo Jacobo-Molina;Raymond G. Nanni

  597
  Citations

• Flexible Use of Nuclear Import Pathways by HIV-1

  KyeongEun Lee;Zandrea Ambrose;Thomas D. Martin;Ilker Oztop

  559
  Citations

• Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

  Kalyan Das;Arthur D. Clark;Paul J. Lewi;Jan Heeres

  545
  Citations

• H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

  Shannon M. Lauberth;Takahiro Nakayama;Xiaolin Wu;Andrea L. Ferris

  534
  Citations

• Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.

  Stefan G. Sarafianos;Kalyan Das;Chris Tantillo;Arthur D. Clark

  532
  Citations

• In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).

  Paul A. J. Janssen;Paul J. Lewi;Eddy Arnold;Frits Daeyaert

  523
  Citations

• Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

  G T Tan;J M Pezzuto;A D Kinghorn;S H Hughes

  516
  Citations

• B-108 Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

  Frank Maldarelli;Xiaolin Wu;Ling Su;Francesco Simonetti

  447
  Citations

• High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations.

  Kalyan Das;Joseph D. Bauman;Arthur D. Clark;Yulia V. Frenkel

  417
  Citations

• Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

  Francesco R. Simonetti;Michele D. Sobolewski;Elizabeth Fyne;Wei Shao

  405
  Citations

• Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids

  Stefan G. Sarafianos;Kalyan Das;Arthur D. Clark;Jianping Ding

  393
  Citations

• In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora

  Yuh-Meei Lin;Herbert Anderson;Michael T. Flavin;Yeah-Huei S. Pai

  392
  Citations

• Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution.

  Jianping Ding;Kalyan Das;Yu Hsiou;Stefan G Sarafianos

  364
  Citations

• Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase.

  Paul L. Boyer;Stefan G. Sarafianos;Edward Arnold;Stephen H. Hughes

  345
  Citations

• Nature, Position, and Frequency of Mutations Made in a Single Cycle of HIV-1 Replication

  Michael E. Abram;Andrea L. Ferris;Wei Shao;W. Gregory Alvord

  340
  Citations