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Gilda Tachedjian

Gilda Tachedjian

University of Melbourne
Australia

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • DNA
  • Enzyme

Her primary scientific interests are in Virology, Biochemistry, Reverse transcriptase, Cyclotide and Efavirenz. In general Virology study, her work on Viral entry often relates to the realm of Pteropus alecto, thereby connecting several areas of interest. Her studies in Viral entry integrate themes in fields like Dendrimer, Potency and Mechanism of action.

The Reverse transcriptase study combines topics in areas such as Mutation and Molecular biology. Her Molecular biology course of study focuses on Zidovudine and Drug resistance, Resistance mutation, Viral load and Nevirapine. Her Efavirenz research incorporates elements of Nucleoside Reverse Transcriptase Inhibitor, Discovery and development of non-nucleoside reverse-transcriptase inhibitors, RNA, Genome and DNA.

Her most cited work include:

  • N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance. (147 citations)
  • N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance. (147 citations)
  • N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance. (147 citations)

What are the main themes of her work throughout her whole career to date?

The scientist’s investigation covers issues in Virology, Reverse transcriptase, Virus, Molecular biology and Viral replication. Gilda Tachedjian has researched Virology in several fields, including Nevirapine, Efavirenz and Drug resistance. Her research integrates issues of Mutation and Enzyme, Polymerase, DNA polymerase in her study of Reverse transcriptase.

She interconnects Microbicides for sexually transmitted diseases, Western blot, Microbiology and Microbicide in the investigation of issues within Virus. Her research investigates the connection between Molecular biology and topics such as Mutant that intersect with issues in Peptide sequence. As a member of one scientific family, she mostly works in the field of Viral replication, focusing on Integrase and, on occasion, Protease.

She most often published in these fields:

  • Virology (97.33%)
  • Reverse transcriptase (71.12%)
  • Virus (46.52%)

What were the highlights of her more recent work (between 2017-2021)?

  • Bacterial vaginosis (17.65%)
  • Internal medicine (16.04%)
  • Lactobacillus (17.65%)

In recent papers she was focusing on the following fields of study:

Gilda Tachedjian mainly investigates Bacterial vaginosis, Internal medicine, Lactobacillus, Gene and Tetherin. Her Bacterial vaginosis research is multidisciplinary, incorporating perspectives in Cytokines metabolism, Intensive care medicine, Hiv transmission and Lactic acid. Her Lactic acid study incorporates themes from Metabolite, Virus and Microbiology.

Her Lactobacillus research is multidisciplinary, incorporating elements of Vagina and Gardnerella vaginalis. As a part of the same scientific family, she mostly works in the field of Vagina, focusing on Sexual partner and, on occasion, Prospective cohort study. As part of the same scientific family, she usually focuses on Gene, concentrating on Mammal and intersecting with Innate immune system.

Between 2017 and 2021, her most popular works were:

  • The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission (59 citations)
  • Anti-HIV-1 Activity of Lactic Acid in Human Cervicovaginal Fluid. (43 citations)
  • The implausible "in vivo" role of hydrogen peroxide as an antimicrobial factor produced by vaginal microbiota (39 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Enzyme

Microbiology, Bacterial vaginosis, Lactic acid, Metabolite and Phascolarctidae are her primary areas of study. Her study ties her expertise on Lactobacillus together with the subject of Microbiology. Her Lactobacillus research is multidisciplinary, relying on both Medical microbiology, Cell hypoxia, Antimicrobial, Hydrogen peroxide and In vivo.

Her biological study spans a wide range of topics, including Tumor necrosis factor alpha, Inflammation, Chemokine, Immune system and Succinic acid. The concepts of her Lactic acid study are interwoven with issues in Ex vivo, In vitro, Organic acid, Vagina and Virus. Her work deals with themes such as Koala retrovirus and Gammaretrovirus, which intersect with Zoology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance.

Soo Huey Yap;Soo Huey Yap;Chih-Wei Sheen;Jonathan Phillip Fahey;Jonathan Phillip Fahey;Mark Zanin.
PLOS Medicine (2007)

203 Citations

Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors.

Nicolas Sluis-Cremer;Gilda Tachedjian;Gilda Tachedjian;Gilda Tachedjian.
Virus Research (2008)

201 Citations

Contraction of the type I IFN locus and unusual constitutive expression of IFN-α in bats.

Peng Zhou;Peng Zhou;Mary Tachedjian;James W. Wynne;Victoria Boyd.
Proceedings of the National Academy of Sciences of the United States of America (2016)

188 Citations

The role of lactic acid production by probiotic Lactobacillus species in vaginal health.

Gilda Tachedjian;Muriel Aldunate;Muriel Aldunate;Catronia S. Bradshaw;Richard A. Cone.
Research in Microbiology (2017)

187 Citations

Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis

Muriel C Aldunate;Muriel C Aldunate;Daniela Srbinovski;Daniela Srbinovski;Anna C Hearps;Anna C Hearps;Catherine F Latham.
Frontiers in Physiology (2015)

177 Citations

Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

Sónia Troeira Henriques;Sónia Troeira Henriques;Yen-Hua Huang;K. Johan Rosengren;Henri G. Franquelim.
Journal of Biological Chemistry (2011)

171 Citations

Structure Activity Relationship of Dendrimer Microbicides with Dual Action Antiviral Activity

David Tyssen;Scott Andrew Henderson;Adam Johnson;Jasminka Sterjovski.
PLOS ONE (2010)

170 Citations

AN IN VIVO MUTATION FROM LEUCINE TO TRYPTOPHAN AT POSITION 210 IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE CONTRIBUTES TO HIGH-LEVEL RESISTANCE TO 3'-AZIDO-3'-DEOXYTHYMIDINE

D J Hooker;G Tachedjian;A E Solomon;A D Gurusinghe.
Journal of Virology (1996)

153 Citations

The packaging and maturation of the HIV-1 Pol proteins.

Melissa K Hill;Gilda Tachedjian;Johnson Mak.
Current HIV Research (2005)

152 Citations

SPL7013 Gel (VivaGel®) Retains Potent HIV-1 and HSV-2 Inhibitory Activity following Vaginal Administration in Humans

Clare F Price;David Tyssen;Secondo Sonza;Secondo Sonza;Ashley Davie.
PLOS ONE (2011)

149 Citations

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