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Microbiology
USA
2026

D-Index & Metrics

Microbiology

D-Index
117
Citations
47077
World Ranking
172
National Ranking
79

Molecular Biology

D-Index
117
Citations
46625
World Ranking
292
National Ranking
176

Research.com Recognitions

  • 2026 - Research.com Microbiology in United States Leader Award
  • 2025 - Research.com Microbiology in United States Leader Award
  • 2006 - Member of the National Academy of Sciences
  • 1995 - Fellow of the American Academy of Arts and Sciences

Overview

Stephen P. Goff is affiliated with Columbia University Medical Center in the United States. Their scientific work spans several fields, primarily within biochemistry, genetics, molecular biology, medicine, immunology, and microbiology. The focus areas include molecular biology, infectious diseases, virology, genetics, and immunology.

The scientist's research topics concentrate on multiple aspects of viral biology and therapeutic approaches, including:

  • HIV research and treatment
  • CRISPR and genetic engineering
  • SARS-CoV-2 and COVID-19 research
  • HIV/AIDS drug development and treatment
  • Virus-based gene therapy research
  • RNA and protein synthesis mechanisms
  • Computational drug discovery methods

Frequent publication venues for the scientist include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Virology
  • Nature
  • Viruses
  • Proceedings of the National Academy of Sciences

Collaboration has been a significant part of their research output, with frequent co-authors being Yosef Sabo, Sho Iketani, Bruce Culbertson, Seo Jung Hong, and Maria I. Luck.

Among recent publications, they contributed to studies addressing viral resistance mechanisms and regulatory processes:

  • "Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir," 2022, Nature
  • "Silencing and Transcriptional Regulation of Endogenous Retroviruses: An Overview," 2020, Viruses
  • "Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir," 2023, Nature
  • "Prrx1 marks stem cells for bone, white adipose tissue and dermis in adult mice," 2022, Nature Genetics
  • "Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir," 2022, bioRxiv (Cold Spring Harbor Laboratory)

Stephen P. Goff has been recognized by professional bodies, being named a Fellow of the American Academy of Arts and Sciences in 1995 and elected a Member of the National Academy of Sciences in 2006.

Best Publications

  • A safe packaging line for gene transfer: separating viral genes on two different plasmids.

    D Markowitz;S Goff;A Bank

  • Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

    Jeremy Luban;Karen Leigh Bossolt;Ettaly K. Franke;Ganjam V. Kalpana

  • Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.

    Weidong Wang;Jacques Côté;Yutong Xue;Sharleen Zhou

  • Construction and use of a safe and efficient amphotropic packaging cell line.

    Dina Markowitz;Stephen Goff;Arthur Bank

  • The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

    Joshua L. Dunaief;Bruce E. Strober;Sushovan Guha;Paul A. Khavari

  • A detailed model of reverse transcription and tests of crucial aspects.

    Eli Gilboa;Sudha W. Mitra;Stephen Goff;David Baltimore

  • Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

    Katrin Mackarehtschian;Jeff D. Hardin;Katrd A. Moore;Sharon Boast

  • Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5

    Ganjam V. Kalpana;Shana Marmon;Weidong Wang;Gerald R. Crabtree

  • Inhibition of Retroviral RNA Production by ZAP, a CCCH-Type Zinc Finger Protein

    Guangxia Gao;Xuemin Guo;Stephen P. Goff

  • Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

    Qingxian Lu;Martin Gore;Martin Gore;Qing Zhang;Todd Camenisch

  • Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: Studies with cloned viral DNA

    Stephen P. Goff;Eli Gilboa;Owen N. Witte;David Baltimore

  • Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

    Unknown

  • Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase.

    Stephen Goff;Paula Traktman;David Baltimore

  • Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture.

    Douglas Richman;Cheng-Kon Shih;Israel Lowy;Janice Rose

  • Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

    Frederic D. Bushman;Nirav Malani;Jason Fernandes;Jason Fernandes;Iván D'Orso;Iván D'Orso

  • Expression of the Zinc-Finger Antiviral Protein Inhibits Alphavirus Replication

    Matthew J. Bick;John-William N. Carroll;Guangxia Gao;Stephen P. Goff

  • Reverse Transcriptase and the Generation of Retroviral DNA

    A Telesnitsky;SP Goff

  • Embryonic stem cells use ZFP809 to silence retroviral DNAs.

    Daniel Wolf;Stephen P. Goff

  • Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors.

    Greg J Towers;Theodora Hatziioannou;Simone Cowan;Stephen P Goff

  • Characterization of Intracellular Reverse Transcription Complexes of Human Immunodeficiency Virus Type 1

    Ariberto Fassati;Stephen P. Goff

  • Retroviral reverse transcriptase: synthesis, structure, and function.

    Goff Sp

Frequent Co-Authors

Peter Gouras
Peter Gouras Columbia University
Jeremy Luban
Jeremy Luban University of Massachusetts Chan Medical School
Pamela L. Schwartzberg
Pamela L. Schwartzberg National Institutes of Health
Arthur Bank
Arthur Bank Columbia University
Debora B. Farber
Debora B. Farber University of California, Los Angeles
Gilda Tachedjian
Gilda Tachedjian Burnet Institute
David Baltimore
David Baltimore California Institute of Technology
Wayne A. Hendrickson
Wayne A. Hendrickson Columbia University
Theodora Hatziioannou
Theodora Hatziioannou Rockefeller University
Greg J. Towers
Greg J. Towers University College London

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