World's Best Scientists 2026 revealed!
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Genetics
USA
2026
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Microbiology
USA
2026

D-Index & Metrics

Microbiology

D-Index
149
Citations
138594
World Ranking
35
National Ranking
19

Genetics

D-Index
145
Citations
119057
World Ranking
154
National Ranking
81

Research.com Recognitions

  • 2026 - Research.com Genetics in United States Leader Award
  • 2026 - Research.com Microbiology in United States Leader Award
  • 2025 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Microbiology in United States Leader Award
  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Frederic D. Bushman is affiliated with the University of Pennsylvania in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology.

The scientist's published work includes papers in venues such as Science, Nature, Nature Reviews Microbiology, Nature Medicine, and Nature Biotechnology. Notable recent publications are:

  • CRISPR-engineered T cells in patients with refractory cancer, 2020, Science
  • Decade-long leukaemia remissions with persistence of CD4+ CAR T cells, 2022, Nature
  • The human virome: assembly, composition and host interactions, 2021, Nature Reviews Microbiology
  • PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial, 2022, Nature Medicine
  • A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells, 2020, Nature Biotechnology

Frederic D. Bushman has collaborated frequently with colleagues including J.K. Everett, Ronald G. Collman, Aoife M. Roche, Kyle Bittinger, and Scott Sherrill-Mix.

The main fields of study for this researcher are Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions across several subfields:

  • Infectious Diseases
  • Molecular Biology
  • Genetics
  • Oncology
  • Epidemiology

Their work addresses a range of scientific topics, including:

  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • Gut microbiota and health
  • Viral gastroenteritis research and epidemiology
  • SARS-CoV-2 and COVID-19 Research
  • CRISPR and Genetic Engineering
  • HIV Research and Treatment

Frederic D. Bushman has published extensively in prominent scientific venues, with repeated contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Nature Medicine
  • Molecular Therapy
  • mBio

The scientist received recognition as a Fellow of the American Association for the Advancement of Science (AAAS) in 2013.

Best Publications

  • QIIME allows analysis of high-throughput community sequencing data.

    J Gregory Caporaso;Justin Kuczynski;Jesse Stombaugh;Kyle Bittinger

  • Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

    Gary D. Wu;Jun Chen;Christian Hoffmann;Christian Hoffmann;Kyle Bittinger

  • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

    Robert A Koeth;Zeneng Wang;Bruce S Levison;Jennifer A Buffa

  • PyNAST: a flexible tool for aligning sequences to a template alignment

    J. Gregory Caporaso;Kyle Bittinger;Frederic D. Bushman;Todd Z. DeSantis

  • HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots

    Astrid R.W. Schröder;Paul Shinn;Huaming Chen;Charles Berry

  • Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

    Salima Hacein-Bey-Abina;Alexandrine Garrigue;Gary P. Wang;Jean Soulier

  • Bayesian community-wide culture-independent microbial source tracking

    Dan Knights;Justin Kuczynski;Emily S. Charlson;Jesse Zaneveld

  • High-fat diet determines the composition of the murine gut microbiome independently of obesity.

    Marie A. Hildebrandt;Christian Hoffmann;Scott A. Sherrill-Mix;Sue A. Keilbaugh

  • Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

    Marina Cavazzana-Calvo;Emmanuel Payen;Olivier Negre;Gary Wang

  • CRISPR-engineered T cells in patients with refractory cancer

    Edward A. Stadtmauer;Joseph A. Fraietta;Megan M. Davis;Adam D. Cohen

  • Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences.

    Rick S Mitchell;Brett F Beitzel;Astrid R. W Schroder;Paul Shinn

  • Topographical Continuity of Bacterial Populations in the Healthy Human Respiratory Tract

    Emily S. Charlson;Kyle Bittinger;Andrew R. Haas;Ayannah S. Fitzgerald

  • Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

    Unknown

  • Global analysis of host-pathogen interactions that regulate early stage HIV-1 replication

    Renate König;Yingyao Zhou;Daniel Elleder;Tracy L. Diamond

  • Associating microbiome composition with environmental covariates using generalized UniFrac distances

    Jun Chen;Kyle Bittinger;Emily S. Charlson;Christian Hoffmann

  • Enterotypes in the landscape of gut microbial community composition

    Paul I. Costea;Falk Hildebrand;Manimozhiyan Arumugam;Fredrik Bäckhed;Fredrik Bäckhed

  • Association Between Breast Milk Bacterial Communities and Establishment and Development of the Infant Gut Microbiome

    Pia S. Pannaraj;Fan Li;Chiara Cerini;Jeffrey M. Bender;Jeffrey M. Bender

  • The human gut virome: Inter-individual variation and dynamic response to diet

    Samuel Minot;Rohini Sinha;Jun Chen;Hongzhe Li

  • Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition.

    Michael D. Miller;Chris M. Farnet;Frederic D. Bushman

  • Archaea and Fungi of the Human Gut Microbiome: Correlations With Diet and Bacterial Residents

    Christian Hoffmann;Serena Dollive;Stephanie Grunberg;Jun Chen

  • A quantitative assay for HIV DNA integration in vivo.

    Scott L. Butler;Mark S.T. Hansen;Frederic D. Bushman

Frequent Co-Authors

Kyle Bittinger
Kyle Bittinger Children's Hospital of Philadelphia
Gary D. Wu
Gary D. Wu University of Pennsylvania
James D. Lewis
James D. Lewis University of Pennsylvania
Ronald G. Collman
Ronald G. Collman University of Pennsylvania
Charles C. Berry
Charles C. Berry University of California, San Diego
Robert N. Baldassano
Robert N. Baldassano Children's Hospital of Philadelphia
Rob Knight
Rob Knight University of California, San Diego
Carl H. June
Carl H. June University of Pennsylvania
Marina Cavazzana-Calvo
Marina Cavazzana-Calvo Necker-Enfants Malades Hospital
David A. Williams
David A. Williams Boston Children's Hospital

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