Alan Engelman

Research.com Recognitions

• 2014 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Best Publications

• Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

  Abraham L. Brass;Derek M. Dykxhoorn;Yair Benita;Nan Yan

  1783
  Citations

• Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases.

  Fred Dyda;Alison B. Hickman;Timothy M. Jenkins;Alan Engelman

  1075
  Citations

• HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer

  Alan Engelman;Kiyoshi Mizuuchi;Robert Craigie

  887
  Citations

• Retroviral intasome assembly and inhibition of DNA strand transfer

  Stephen Hare;Saumya Shree Gupta;Saumya Shree Gupta;Eugene Valkov;Eugene Valkov;Alan N Engelman

  782
  Citations

• Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro.

  A Engelman;R Craigie

  694
  Citations

• The structural biology of HIV-1: mechanistic and therapeutic insights.

  Alan Engelman;Peter Cherepanov

  627
  Citations

• LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

  Ming-Chieh Shun;Nidhanapati K. Raghavendra;Nick Vandegraaff;Janet E. Daigle

  579
  Citations

• Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.

  A Engelman;G Englund;J M Orenstein;M A Martin

  560
  Citations

• Flexible Use of Nuclear Import Pathways by HIV-1

  KyeongEun Lee;Zandrea Ambrose;Thomas D. Martin;Ilker Oztop

  559
  Citations

• Haematopoietic stem and progenitor cells from human pluripotent stem cells

  Ryohichi Sugimura;Deepak Kumar Jha;Areum Han;Clara Soria-Valles

  534
  Citations

• Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

  Peter Cherepanov;Andre L. B. Ambrosio;Shaila Rahman;Tom Ellenberger

  494
  Citations

• Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding.

  Frederic D. Bushman;Alan Engelman;Ira Palmer;Paul Wingfield

  477
  Citations

• Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex.

  A Engelman;F D Bushman;R Craigie

  461
  Citations

• Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity

  James K. Nuñez;Amy S. Y. Lee;Alan Engelman;Jennifer A. Doudna

  405
  Citations

• Solution structure of the DNA binding domain of HIV-1 integrase.

  P.J Lodi;J.A Ernst;J Kuszewski;A.B Hickman

  403
  Citations

• A Soluble Active Mutant of HIV-1 Integrase INVOLVEMENT OF BOTH THE CORE AND CARBOXYL-TERMINAL DOMAINS IN MULTIMERIZATION

  Timothy M. Jenkins;Alan Engelman;Rodolfo Ghirlando;Robert Craigie

  378
  Citations

• The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding.

  A Engelman;A B Hickman;R Craigie

  347
  Citations

• Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration

  Jean L. Mbisa;Rebekah Barr;James A. Thomas;Nick Vandegraaff

  345
  Citations

• Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.

  Peter Cherepanov;Eric Devroe;Pamela A. Silver;Alan Engelman

  336
  Citations

• Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.

  Timothy M. Jenkins;Dominic Esposito;Alan Engelman;Robert Craigie

  326
  Citations