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D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
7616
World Ranking
18102
National Ranking
7401

Overview

James R. Fuchs is affiliated with The Ohio State University in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine.

The primary fields of study in Fuchs's work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, the main subfields covered are:

  • Molecular Biology
  • Infectious Diseases
  • Pharmacology
  • Virology
  • Ecology, Evolution, Behavior and Systematics

The scientist's research topics frequently focus on:

  • HIV/AIDS drug development and treatment
  • HIV Research and Treatment
  • Microbial Natural Products and Biosynthesis
  • Ubiquitin and proteasome pathways
  • Phytochemical compounds biological activities
  • Biochemical and Molecular Research
  • Research on Leishmaniasis Studies

Frequent coauthors in Fuchs's research collaborations include:

  • A. Douglas Kinghorn
  • Joanna E. Burdette
  • Daniel Adu-Ampratwum
  • Mamuka Kvaratskhelia
  • Arun S. Annamalai

Publications by James R. Fuchs have appeared repeatedly in prominent scientific journals, with the most frequent venues being:

  • mBio
  • ACS Medicinal Chemistry Letters
  • Journal of Natural Products
  • Natural Product Reports
  • Cancer Research

Selected recent papers include:

  • Structural and mechanistic bases for a potent HIV-1 capsid inhibitor, 2020, Science
  • Discovery of Anticancer Agents of Diverse Natural Origin, 2022, Journal of Natural Products
  • Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir, 2022, mBio
  • G2Retro as a two-step graph generative models for retrosynthesis prediction, 2023, Communications Chemistry
  • 15N Stable Isotope Labeling and Comparative Metabolomics Facilitates Genome Mining in Cultured Cyanobacteria, 2020, ACS Chemical Biology

Best Publications

  • Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

    Thomas A Mace;Zeenath Ameen;Amy Collins;Sylwia E. Wojcik

  • Curcumin is a potent DNA hypomethylation agent.

    Zhongfa Liu;Zhiliang Xie;William Jones;Ryan E. Pavlovicz

  • Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells

    Li Lin;Brian Hutzen;Mingxin Zuo;Sarah Ball

  • Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.

    Kellie A. Jurado;Hao Wang;Alison Slaughter;Lei Feng

  • Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

    Stephanie M. Bester;Guochao Wei;Haiyan Zhao;Daniel Adu-Ampratwum

  • Total synthesis of (+/-)-perophoramidine.

    James R. Fuchs;Raymond L. Funk

  • Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.

    Jacques J. Kessl;Nivedita Jena;Yasuhiro Koh;Humeyra Taskent-Sezgin

  • Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030

    Lin L;Liu Y;Li H;Li Pk

  • Structure–activity relationship studies of curcumin analogues

    James R. Fuchs;Bulbul Pandit;Deepak Bhasin;Jonathan P. Etter

  • A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

    Li Lin;Li Lin;Stephanie Deangelis;Elizabeth Foust;James Fuchs

  • Modulation of DNA Methylation by a Sesquiterpene Lactone Parthenolide

    Zhongfa Liu;Shujun Liu;Zhiliang Xie;Ryan E. Pavlovicz

  • STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH⁺/CD133⁺ stem cell-like human colon cancer cells

    Li Lin;James Fuchs;Chenglong Li;Veronica Olson

  • The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.

    Matthew A. Bill;James R. Fuchs;Chenglong Li;Jennifer Yui

  • Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species

    Li Pan;John L. Woodard;David M. Lucas;James R. Fuchs

  • HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis

    Jacques J. Kessl;Sebla B. Kutluay;Sebla B. Kutluay;Dana Townsend;Stephanie Rebensburg

  • A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase

    Amit Sharma;Alison Slaughter;Nivedita Jena;Lei Feng

  • Intramolecular diels-alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles.

    Gregory I. Elliott;James R. Fuchs;Brian S. J. Blagg;Hayato Ishikawa

  • Discovery of Anticancer Agents of Diverse Natural Origin.

    A. Douglas Kinghorn;Esperanza J. Carcache De Blanco;David M. Lucas;H. Liva Rakotondraibe

  • HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

    Hao Wang;Kellie Ann Jurado;Xiaolin Wu;Ming-Chieh Shun

  • Total synthesis of (+/-)-lennoxamine and (+/-)-aphanorphine by intramolecular electrophilic aromatic substitution reactions of 2-amidoacroleins.

    James R. Fuchs;Raymond L. Funk

Frequent Co-Authors

A. Douglas Kinghorn
A. Douglas Kinghorn The Ohio State University
Mamuka Kvaratskhelia
Mamuka Kvaratskhelia University of Colorado Denver
Abhay R. Satoskar
Abhay R. Satoskar The Ohio State University
Alan Engelman
Alan Engelman Harvard University
Dong M. Shin
Dong M. Shin Emory University
Ronald M. Levy
Ronald M. Levy Temple University
Fadlo R. Khuri
Fadlo R. Khuri American University of Beirut
Eric M. Poeschla
Eric M. Poeschla University of Colorado Anschutz Medical Campus
Jianhua Yu
Jianhua Yu City Of Hope National Medical Center

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