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Chemistry

D-Index
119
Citations
53958
World Ranking
513
National Ranking
223

Overview

Dale L. Boger is affiliated with the Scripps Research Institute in the United States. Their research contributions span multiple areas within chemistry and related fields, particularly focusing on organic synthesis and molecular biology.

The primary fields of study in which Dale L. Boger has published include:

  • Chemistry
  • Biochemistry, Genetics and Molecular Biology

The subfields of study reflect a strong emphasis on chemical synthesis and biological applications:

  • Organic Chemistry
  • Materials Chemistry
  • Molecular Biology
  • Pharmacology
  • Immunology

The main topics covered in their research consist of:

  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Click Chemistry and Applications
  • Microbial Natural Products and Biosynthesis
  • Alkaloids: synthesis and pharmacology
  • Chemical Synthesis and Analysis
  • Chemical synthesis and alkaloids

Dale L. Boger has produced research published in various esteemed venues, demonstrating a multidisciplinary approach:

  • The Cambridge Structural Database
  • Journal of the American Chemical Society
  • The Journal of Organic Chemistry
  • Accounts of Chemical Research
  • ACS Chemical Biology

Frequent collaborators in their research include:

  • Zhi-Chen Wu
  • Shreyosree Chatterjee
  • Maxwell J. Moore
  • D. Jamin Keith
  • Pengjin Qin

Notable recent papers illustrate the scope and impact of their work:

  • Next-Generation Total Synthesis of Vancomycin, 2020, Journal of the American Chemical Society
  • Maxamycins: Durable Antibiotics Derived by Rational Redesign of Vancomycin, 2020, Accounts of Chemical Research
  • The quest for supernatural products: the impact of total synthesis in complex natural products medicinal chemistry, 2020, Natural Product Reports
  • Discovery of small-molecule enzyme activators by activity-based protein profiling, 2020, Nature Chemical Biology
  • Vancomycin C-Terminus Guanidine Modifications and Further Insights into an Added Mechanism of Action Imparted by a Peripheral Structural Modification, 2020, ACS Infectious Diseases

Best Publications

  • Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

    Benjamin F. Cravatt;Dan K. Giang;Stephen P. Mayfield;Dale L. Boger

  • Hetero Diels-Alder methodology in organic synthesis

    Dale L. Boger;Steven M. Weinreb

  • Diels-Alder reactions of heterocyclic aza dienes. Scope and applications

    Dale L. Boger

  • Chemical characterization of a family of brain lipids that induce sleep.

    Benjamin F. Cravatt;Oscar Prospero-Garcia;Gary Siuzdak;Norton B. Gilula

  • Diels-Alder reactions of azadienes

    Dale L. Boger

  • A Simple, High-Resolution Method for Establishing DNA Binding Affinity and Sequence Selectivity

    Dale L. Boger;Brian E. Fink;Steven R. Brunette;Winston C. Tse

  • Total Syntheses of Ningalin A, Lamellarin O, Lukianol A, and Permethyl Storniamide A Utilizing Heterocyclic Azadiene Diels−Alder Reactions

    Dale L. Boger;Christopher W. Boyce;Marc A. Labroli;Clark A. Sehon

  • Discovering potent and selective reversible inhibitors of enzymes in complex proteomes.

    Donmienne Leung;Christophe Hardouin;Dale L Boger;Benjamin F Cravatt

  • Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo.

    Steve Silletti;Torsten Kessler;Joel Goldberg;Dale L. Boger

  • CC-1065 AND THE DUOCARMYCINS : UNDERSTANDING THEIR BIOLOGICAL FUNCTION THROUGH MECHANISTIC STUDIES

    Dale L. Boger;Douglas S. Johnson

  • Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

    Thorsten Berg;Steven B. Cohen;Joel Desharnais;Corinna Sonderegger

  • Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues.

    Hayato Ishikawa;David A. Colby;Shigeki Seto;Porino Va

  • Mechanisms of in situ activation for DNA-targeting antitumor agents.

    Scott E Wolkenberg;Dale L Boger

  • Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity

    Aron H. Lichtman;Donmienne Leung;Christopher C. Shelton;Alan Saghatelian

  • Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain

    Steven G. Kinsey;Jonathan Z. Long;Scott T. O'Neal;Rehab A. Abdullah

  • Fe(III)/NaBH4-Mediated Free Radical Hydrofluorination of Unactivated Alkenes

    Timothy J. Barker;Dale L. Boger

  • A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity.

    Winston C. Tse;Dale L. Boger

  • Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide

    Dale L. Boger;Haruhiko Sato;Aaron E. Lerner;Michael P. Hedrick

  • The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells.

    Xiaojun Guan;Benjamin F. Cravatt;George R. Ehring;James E. Hall

  • CC-1065 and the Duocarmycins: Synthetic Studies.

    Dale L. Boger;Christopher W. Boyce;Robert M. Garbaccio;Joel A. Goldberg

Frequent Co-Authors

Benjamin F. Cravatt
Benjamin F. Cravatt Scripps Research Institute
Ian A. Wilson
Ian A. Wilson Scripps Research Institute
Richard A. Lerner
Richard A. Lerner Scripps Research Institute
Hayato Ishikawa
Hayato Ishikawa Kumamoto University
Stephen J. Benkovic
Stephen J. Benkovic Pennsylvania State University
Robert S. Coleman
Robert S. Coleman The Ohio State University
James S. Panek
James S. Panek Boston University
Bruce Beutler
Bruce Beutler The University of Texas Southwestern Medical Center
David A. Cheresh
David A. Cheresh University of California, San Diego
Raymond C. Stevens
Raymond C. Stevens University of Southern California

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