D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 71 Citations 18,632 199 World Ranking 14446 National Ranking 448

Research.com Recognitions

Awards & Achievements

2004 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for her pioneering work on the molecular neurobiology of opioid-controlled behaviors the results of which have very important implications,,for the treatment of pain drug abuse and emotional disorders."

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • Receptor
  • Internal medicine

Her scientific interests lie mostly in Receptor, Opioid, Opioid receptor, Pharmacology and Neuroscience. Her Receptor research includes elements of Molecular biology and Endocrinology. The study incorporates disciplines such as Drug tolerance, Cannabinoid and Addiction in addition to Opioid.

Her Opioid receptor study combines topics from a wide range of disciplines, such as -Naloxone, Knockout mouse and Opioid peptide. Her Pharmacology research integrates issues from Neuropeptide FF receptor, Chronic pain and Nociception. Her studies deal with areas such as Nociceptor, μ-opioid receptor, δ-opioid receptor and Drug as well as Neuroscience.

Her most cited work include:

  • Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene (1396 citations)
  • The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. (901 citations)
  • Reward Processing by the Opioid System in the Brain (590 citations)

What are the main themes of her work throughout her whole career to date?

Brigitte L. Kieffer mainly focuses on Receptor, Opioid, Opioid receptor, Pharmacology and Neuroscience. Her research on Receptor frequently links to adjacent areas such as Endocrinology. Her research integrates issues of Analgesic and Addiction in her study of Opioid.

The Opioid receptor study combines topics in areas such as 5-HT5A receptor, Opioid peptide, Molecular biology, Cell biology and Endogenous opioid. Her studies deal with areas such as -Naloxone, Naltrexone and Nociception as well as Pharmacology. She interconnects Antidepressant and Dynorphin in the investigation of issues within κ-opioid receptor.

She most often published in these fields:

  • Receptor (57.64%)
  • Opioid (48.09%)
  • Opioid receptor (37.90%)

What were the highlights of her more recent work (between 2017-2021)?

  • Neuroscience (43.31%)
  • Opioid (48.09%)
  • Receptor (57.64%)

In recent papers she was focusing on the following fields of study:

Her primary scientific interests are in Neuroscience, Opioid, Receptor, μ-opioid receptor and Addiction. In her study, Home cage, Perseveration, Habituation and Somatosensory system is strongly linked to Knockout mouse, which falls under the umbrella field of Neuroscience. Her Opioid research incorporates themes from Endocrinology and Pharmacology.

Her research investigates the link between Receptor and topics such as Cell biology that cross with problems in Substantia innominata and Tyrosine hydroxylase. The various areas that Brigitte L. Kieffer examines in her μ-opioid receptor study include Morphine, Drug and Endogenous opioid. The concepts of her Addiction study are interwoven with issues in Opioid system, Vulnerability and Opiate.

Between 2017 and 2021, her most popular works were:

  • Opioid receptors: drivers to addiction? (101 citations)
  • Opioid receptors: drivers to addiction? (101 citations)
  • Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons. (37 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

Neuroscience, Receptor, μ-opioid receptor, Opioid and Ventral tegmental area are her primary areas of study. Her Neuroscience research includes themes of Glycine, Glycine receptor, Neurotransmission, Dynorphin and Neuropeptide. Her work in the fields of Receptor, such as G protein-coupled receptor, intersects with other areas such as Nonsense mutation.

Her μ-opioid receptor research integrates issues from Endogenous opioid, Morphine, Pharmacology, Drug and Drug discovery. Within one scientific family, Brigitte L. Kieffer focuses on topics pertaining to Opiate under Drug, and may sometimes address concerns connected to Functional selectivity and Opioid receptor. The Opioid system research Brigitte L. Kieffer does as part of her general Opioid study is frequently linked to other disciplines of science, such as Extramural, therefore creating a link between diverse domains of science.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes;Rafael Maldonado;Frédéric Simonin;Olga Valverde.
Nature (1996)

1821 Citations

The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization.

Brigitte L. Kieffer;Katia Befort;Claire Gaveriaux-Ruff;Christian G. Hirth.
Proceedings of the National Academy of Sciences of the United States of America (1992)

1420 Citations

Reward Processing by the Opioid System in the Brain

Julie Le Merrer;Jérôme A. J. Becker;Katia Befort;Brigitte L. Kieffer.
Physiological Reviews (2009)

815 Citations

Exploring the opioid system by gene knockout.

Brigitte L Kieffer;Claire Gavériaux-Ruff.
Progress in Neurobiology (2002)

795 Citations

Opioids: first lessons from knockout mice.

Brigitte L. Kieffer.
Trends in Pharmacological Sciences (1999)

629 Citations

Disruption of the κ-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ-agonist U-50,488H and attenuates morphine withdrawal

Frédéric Simonin;Olga Valverde;Claire Smadja;Susan Slowe.
The EMBO Journal (1998)

553 Citations

Recent advances in molecular recognition and signal transduction of active peptides: Receptors for opioid peptides

Brigitte L. Kieffer.
Cellular and Molecular Neurobiology (1995)

519 Citations

Deficit in Attachment Behavior in Mice Lacking the μ-Opioid Receptor Gene

Anna Moles;Brigitte L. Kieffer;Francesca R. D'Amato.
Science (2004)

515 Citations

Atrial G protein-activated K+ channel: expression cloning and molecular properties.

N Dascal;W Schreibmayer;N F Lim;W Wang.
Proceedings of the National Academy of Sciences of the United States of America (1993)

494 Citations

Dissociation of the opioid receptor mechanisms that control mechanical and heat pain.

Grégory Scherrer;Noritaka Imamachi;Yu-Qing Cao;Candice Contet.
Cell (2009)

477 Citations

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