2004 - Richard Lounsbery Award, National Academy of Sciences and the French Academy of Sciences for her pioneering work on the molecular neurobiology of opioid-controlled behaviors the results of which have very important implications,,for the treatment of pain drug abuse and emotional disorders."
Her scientific interests lie mostly in Receptor, Opioid, Opioid receptor, Pharmacology and Neuroscience. Her Receptor research includes elements of Molecular biology and Endocrinology. The study incorporates disciplines such as Drug tolerance, Cannabinoid and Addiction in addition to Opioid.
Her Opioid receptor study combines topics from a wide range of disciplines, such as -Naloxone, Knockout mouse and Opioid peptide. Her Pharmacology research integrates issues from Neuropeptide FF receptor, Chronic pain and Nociception. Her studies deal with areas such as Nociceptor, μ-opioid receptor, δ-opioid receptor and Drug as well as Neuroscience.
Brigitte L. Kieffer mainly focuses on Receptor, Opioid, Opioid receptor, Pharmacology and Neuroscience. Her research on Receptor frequently links to adjacent areas such as Endocrinology. Her research integrates issues of Analgesic and Addiction in her study of Opioid.
The Opioid receptor study combines topics in areas such as 5-HT5A receptor, Opioid peptide, Molecular biology, Cell biology and Endogenous opioid. Her studies deal with areas such as -Naloxone, Naltrexone and Nociception as well as Pharmacology. She interconnects Antidepressant and Dynorphin in the investigation of issues within κ-opioid receptor.
Her primary scientific interests are in Neuroscience, Opioid, Receptor, μ-opioid receptor and Addiction. In her study, Home cage, Perseveration, Habituation and Somatosensory system is strongly linked to Knockout mouse, which falls under the umbrella field of Neuroscience. Her Opioid research incorporates themes from Endocrinology and Pharmacology.
Her research investigates the link between Receptor and topics such as Cell biology that cross with problems in Substantia innominata and Tyrosine hydroxylase. The various areas that Brigitte L. Kieffer examines in her μ-opioid receptor study include Morphine, Drug and Endogenous opioid. The concepts of her Addiction study are interwoven with issues in Opioid system, Vulnerability and Opiate.
Neuroscience, Receptor, μ-opioid receptor, Opioid and Ventral tegmental area are her primary areas of study. Her Neuroscience research includes themes of Glycine, Glycine receptor, Neurotransmission, Dynorphin and Neuropeptide. Her work in the fields of Receptor, such as G protein-coupled receptor, intersects with other areas such as Nonsense mutation.
Her μ-opioid receptor research integrates issues from Endogenous opioid, Morphine, Pharmacology, Drug and Drug discovery. Within one scientific family, Brigitte L. Kieffer focuses on topics pertaining to Opiate under Drug, and may sometimes address concerns connected to Functional selectivity and Opioid receptor. The Opioid system research Brigitte L. Kieffer does as part of her general Opioid study is frequently linked to other disciplines of science, such as Extramural, therefore creating a link between diverse domains of science.
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Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene
Hans W. D. Matthes;Rafael Maldonado;Frédéric Simonin;Olga Valverde.
The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization.
Brigitte L. Kieffer;Katia Befort;Claire Gaveriaux-Ruff;Christian G. Hirth.
Proceedings of the National Academy of Sciences of the United States of America (1992)
Reward Processing by the Opioid System in the Brain
Julie Le Merrer;Jérôme A. J. Becker;Katia Befort;Brigitte L. Kieffer.
Physiological Reviews (2009)
Exploring the opioid system by gene knockout.
Brigitte L Kieffer;Claire Gavériaux-Ruff.
Progress in Neurobiology (2002)
Opioids: first lessons from knockout mice.
Brigitte L. Kieffer.
Trends in Pharmacological Sciences (1999)
Disruption of the κ-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ-agonist U-50,488H and attenuates morphine withdrawal
Frédéric Simonin;Olga Valverde;Claire Smadja;Susan Slowe.
The EMBO Journal (1998)
Recent advances in molecular recognition and signal transduction of active peptides: Receptors for opioid peptides
Brigitte L. Kieffer.
Cellular and Molecular Neurobiology (1995)
Deficit in Attachment Behavior in Mice Lacking the μ-Opioid Receptor Gene
Anna Moles;Brigitte L. Kieffer;Francesca R. D'Amato.
Atrial G protein-activated K+ channel: expression cloning and molecular properties.
N Dascal;W Schreibmayer;N F Lim;W Wang.
Proceedings of the National Academy of Sciences of the United States of America (1993)
Dissociation of the opioid receptor mechanisms that control mechanical and heat pain.
Grégory Scherrer;Noritaka Imamachi;Yu-Qing Cao;Candice Contet.
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