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Research.com Recognitions

  • 2026 - Research.com Medicine in United States Leader Award
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  • 2025 - Research.com Medicine in United States Leader Award
  • 2023 - Research.com Medicine in United States Leader Award
  • 2017 - Member of the National Academy of Medicine (NAM)
  • 2001 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

George F. Koob is affiliated with the National Institute on Drug Abuse in the United States. Their research spans the fields of Medicine and Neuroscience, with a significant focus on Cellular and Molecular Neuroscience, Physiology, Epidemiology, Cognitive Neuroscience, and Endocrine and Autonomic Systems.

The scientist's recent publications include several influential papers such as Opioid use disorder (2020, Nature Reviews Disease Primers), Alcohol-Related Deaths During the COVID-19 Pandemic (2022, JAMA), Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development (2020, Pharmacological Reviews), The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission (2023, JCI Insight), and Addiction as a Coping Response: Hyperkatifeia, Deaths of Despair, and COVID-19 (2020, American Journal of Psychiatry).

Koob's work addresses various topics related to neuroscience and addiction, including:

  • Neurotransmitter Receptor Influence on Behavior
  • Stress Responses and Cortisol
  • Substance Abuse Treatment and Outcomes
  • Neuropeptides and Animal Physiology
  • Regulation of Appetite and Obesity
  • Adipose Tissue and Metabolism
  • Alcohol Consumption and Health Effects

Frequent coauthors throughout their career include Leandro F. Vendruscolo, Nora D. Volkow, Renata C.N. Marchette, Lorenzo Leggio, and Brendan J. Tunstall.

Koob's research has appeared repeatedly in venues such as Biological Psychiatry, Alcohol, Neuropharmacology, Neuropsychopharmacology, and Molecular Psychiatry.

In addition to journal articles, they have contributed to book publications, notably with Rowman & Littlefield, including the title Escaping Addiction published in 2023.

Recognitions include membership in the National Academy of Medicine since 2017 and fellowship in the American Association for the Advancement of Science since 2001.

Best Publications

  • Neurocircuitry of Addiction

    George F Koob;Nora D Volkow

  • Drug addiction, dysregulation of reward, and allostasis.

    George F Koob;Michel Le Moal

  • Neurobiology of addiction: A neurocircuitry analysis.

    George F Koob;Nora D Volkow

  • Drug Abuse: Hedonic Homeostatic Dysregulation

    George F. Koob;Michel Le Moal;Michel Le Moal

  • Drugs of abuse: anatomy, pharmacology and function of reward pathways

    George F. Koob

  • Cellular and molecular mechanisms of drug dependence.

    George F. Koob;Floyd E. Bloom

  • Neurobiologic Advances from the Brain Disease Model of Addiction

    Nora D. Volkow;George F. Koob;A. Thomas McLellan

  • Addiction and the Brain Antireward System

    George F. Koob;Michel Le Moal

  • Neuroscience of Addiction

    George F Koob;Pietro Paolo Sanna;Floyd E Bloom

  • Transition from moderate to excessive drug intake : Change in Hedonic set point

    S. H. Ahmed;G. F. Koob

  • A Role for Brain Stress Systems in Addiction

    George F. Koob

  • Plasticity of reward neurocircuitry and the 'dark side' of drug addiction.

    George F Koob;Michel Le Moal

  • Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress.

    Tracy L. Bale;Angelo Contarino;George W. Smith;Raymond Chan

  • Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development.

    George W. Smith;Jean Michel Aubry;Francoise Dellu;Angelo Contarino

  • Stress, Dysregulation of Drug Reward Pathways, and the Transition to Drug Dependence

    George Koob;Mary Jeanne Kreek

  • Alcoholism: allostasis and beyond.

    George F. Koob

  • Neurobiological similarities in depression and drug dependence : A self-medication hypothesis

    Athina Markou;Thomas R. Kosten;George F. Koob

  • Dramatic decreases in brain reward function during nicotine withdrawal

    Mark P. Epping-Jordan;Shelly S. Watkins;George F. Koob;Athina Markou

  • Corticotropin releasing factor produces behavioural activation in rats

    Richard E. Sutton;George F. Koob;Michel Le Moal;Jean Rivier

  • The neurobiology of addiction: an overview.

    Amanda J. Roberts;George F. Koob

Frequent Co-Authors

Leandro F. Vendruscolo
Leandro F. Vendruscolo National Institutes of Health
Floyd E. Bloom
Floyd E. Bloom Scripps Research Institute
Eric P. Zorrilla
Eric P. Zorrilla Scripps Research Institute
Athina Markou
Athina Markou University of California, San Diego
Olivier George
Olivier George University of California, San Diego
Friedbert Weiss
Friedbert Weiss Scripps Research Institute
Gery Schulteis
Gery Schulteis University of California, San Diego
Neal R. Swerdlow
Neal R. Swerdlow University of California, San Diego
Serge H. Ahmed
Serge H. Ahmed University of Bordeaux
Wylie Vale
Wylie Vale Salk Institute for Biological Studies

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