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Chemistry

D-Index
44
Citations
5927
World Ranking
16995
National Ranking
2581

Overview

Tian-Miao Ou is affiliated with Sun Yat-sen University in China, focusing on research at the intersection of biochemistry, genetics, molecular biology, and medicine. Their body of work demonstrates an emphasis on molecular biology and organic chemistry, with applications relevant to cancer therapeutics and genetic mechanisms.

Their recent publications reveal a consistent engagement with topics such as DNA and nucleic acid chemistry, advanced biosensing and bioanalysis techniques, RNA interference and gene delivery, RNA and protein synthesis mechanisms, cancer therapeutics, catalytic C-H functionalization methods, and DNA repair mechanisms.

Key papers authored by Tian-Miao Ou include:

  • "Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast cancer" (2022, Nucleic Acids Research)
  • "Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors" (2020, Journal of Medicinal Chemistry)
  • "Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer" (2022, Journal of Medicinal Chemistry)
  • "Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex" (2022, Journal of Medicinal Chemistry)
  • "Therapeutic targeting RORγ with natural product N-hydroxyapiosporamide for small cell lung cancer by reprogramming neuroendocrine fate" (2022, Pharmacological Research)

The frequent co-authors who have collaborated extensively with Tian-Miao Ou are:

  • Honggen Wang
  • Jia-Heng Tan
  • Zhi-Shu Huang
  • Qingjiang Li
  • Shi-Liang Huang

Most publications appear in the following venues, reflecting a concentration in medicinal chemistry and molecular-related journals:

  • Journal of Medicinal Chemistry
  • European Journal of Medicinal Chemistry
  • Nucleic Acids Research
  • Pharmacological Research
  • Aging

Their research spans main fields including biochemistry, genetics, molecular biology, and medicine. More specifically, subfields include molecular biology, organic chemistry, epidemiology, pulmonary and respiratory medicine, and oncology. The primary research topics cover areas such as DNA and nucleic acid chemistry, advanced biosensing, RNA interference, protein synthesis mechanisms, cancer therapeutics, catalytic C-H functionalization methods, and DNA repair mechanisms.

Best Publications

  • G-Quadruplexes: Targets in Anticancer Drug Design

    Tian Miao Ou;Yu Jing Lu;Jia Heng Tan;Zhi Shu Huang

  • Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives

    Tian-Miao Ou;Yu-Jing Lu;Chi Zhang;Zhi-Shu Huang

  • Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase.

    Jin Lin Zhou;Yu Jing Lu;Tian Miao Ou;Jun Min Zhou

  • Tracking the Dynamic Folding and Unfolding of RNA G-Quadruplexes in Live Cells.

    Xiu-Cai Chen;Shuo-Bin Chen;Jing Dai;Jia-Hao Yuan

  • 5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation.

    Yu Jing Lu;Tian Miao Ou;Jia Heng Tan;Jin Qiang Hou

  • 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA

    Wan-Jin Zhang;Tian-Miao Ou;Yu-Jing Lu;Ying-Yu Huang

  • 9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc

    Yan Ma;Tian-Miao Ou;Jin-Qiang Hou;Yu-Jing Lu

  • Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid⁻Protein Interaction.

    Zhi-Yin Sun;Xiao-Na Wang;Sui-Qi Cheng;Xiao-Xuan Su

  • Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe

    Shuo-Bin Chen;Ming-Hao Hu;Guo-Cai Liu;Jin Wang

  • Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.

    Ming-Hao Hu;Shuo-Bin Chen;Bo Wang;Tian-Miao Ou

  • Inhibition of Cell Proliferation by Quindoline Derivative (SYUIQ-05) through its Preferential Interaction with c-myc Promoter G-Quadruplex

    Tian-Miao Ou;Jing Lin;Yu-Jing Lu;Jin-Qiang Hou

  • Conformation Selective Antibody Enables Genome Profiling and Leads to Discovery of Parallel G-Quadruplex in Human Telomeres

    Hui-Yun Liu;Qi Zhao;Tian-Peng Zhang;Yue Wu

  • Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex.

    Ming-Hao Hu;Ming-Hao Hu;Yu-Qing Wang;Ze-Yi Yu;Lu-Ni Hu

  • Turning off Transcription of the bcl-2 Gene by Stabilizing the bcl-2 Promoter Quadruplex with Quindoline Derivatives

    Xiao-Dong Wang;Tian-Miao Ou;Yu-Jing Lu;Zeng Li

  • Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer’s disease

    Shang-Ying Chen;Yuan Chen;Yan-Ping Li;Shu-Han Chen

  • Isaindigotone derivatives: a new class of highly selective ligands for telomeric G-quadruplex DNA.

    Jia Heng Tan;Tian Miao Ou;Jin Qiang Hou;Yu Jing Lu

  • Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation.

    Wen Luo;Yan-Ping Li;Yan He;Shi-Liang Huang

  • Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry

    De-Ying Zeng;Guo-Tao Kuang;Shi-Ke Wang;Wang Peng

  • Stabilization of G-quadruplex DNA by C-5-methyl-cytosine in bcl-2 promoter: implications for epigenetic regulation.

    Jing Lin;Jin-qiang Hou;Han-dan Xiang;Yi-yong Yan

  • Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands.

    Yan Ma;Tian-Miao Ou;Jia-Heng Tan;Jin-Qiang Hou

  • Development of a new colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids

    Jin-Wu Yan;Jin-Wu Yan;Shuo-Bin Chen;Hui-Yun Liu;Wen-Jie Ye

  • Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.

    Bin Wang;Yi-Chi Mai;Yue Li;Jin-Qiang Hou

  • Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors

    Bing-Lei Yao;Yan-Wen Mai;Shuo-Bin Chen;Hua-Ting Xie

Frequent Co-Authors

Jia-Heng Tan
Jia-Heng Tan Sun Yat-sen University
Zhi-Shu Huang
Zhi-Shu Huang Sun Yat-sen University
Kwok-Yin Wong
Kwok-Yin Wong Hong Kong Polytechnic University
Frank Glorius
Frank Glorius University of Münster
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Albert S. C. Chan
Albert S. C. Chan Sun Yat-sen University
Dik-Lung Ma
Dik-Lung Ma Hong Kong Baptist University
Jin Wang
Jin Wang Stony Brook University

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