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Chemistry

D-Index
97
Citations
36696
World Ranking
1457
National Ranking
561

Biology and Biochemistry

D-Index
99
Citations
37626
World Ranking
1582
National Ranking
887

Overview

Laurence H. Hurley is affiliated with the University of Arizona in the United States. Their research primarily spans the broad field of Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology as the dominant subfield among their work. Other subfields include Cell Biology, Epidemiology, Physiology, and Biotechnology.

The scientist's work covers various specialized topics, including:

  • DNA and Nucleic Acid Chemistry
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • RNA and protein synthesis mechanisms
  • Cancer therapeutics and mechanisms
  • Heme Oxygenase-1 and Carbon Monoxide
  • Hemoglobin structure and function

Laurence H. Hurley has contributed to multiple publications in different scientific venues. Frequent publication venues include:

  • Bioorganic & Medicinal Chemistry Letters
  • Oncotarget
  • Journal of the American Chemical Society
  • Science
  • Cell Reports

Selected recent papers authored or coauthored by Laurence H. Hurley include:

  • "DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells," 2020, Journal of the American Chemical Society
  • "A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex)," 2022, Bioorganic & Medicinal Chemistry Letters
  • "Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases," 2020, Cell Reports
  • "The role of G-Quadruplex DNA in Paraspeckle formation in cancer," 2021, Biochimie
  • "A synthetic lethal approach to drug targeting of G-quadruplexes based on CX-5461," 2023, Bioorganic & Medicinal Chemistry Letters

Frequent coauthors working with Laurence H. Hurley include:

  • Vijay Gokhale
  • Cameron W. Evans
  • K. Swaminathan Iyer
  • Nicole M. Smith
  • Hong Xu

Best Publications

  • Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription.

    Adam Siddiqui-Jain;Cory L. Grand;David J. Bearss;Laurence H. Hurley

  • Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

    Shankar Balasubramanian;Laurence H. Hurley;Stephen Neidle

  • DNA and its associated processes as targets for cancer therapy

    Laurence H. Hurley

  • Inhibition of human telomerase by a G-quadruplex-interactive compound.

    Daekyu Sun;Brian Thompson;Brian E. Cathers;Miguel Salazar

  • Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.

    Mu Yong Kim;Hariprasad Vankayalapati;Kazuo Shin-Ya;Konstanty Wierzba

  • G-quadruplex DNA: a potential target for anti-cancer drug design

    Haiyong Han;Laurence H Hurley

  • Cationic Porphyrins as Telomerase Inhibitors: the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA

    Richard T. Wheelhouse;Daekyu Sun;Haiyong Han;and Frank Xiaoguang Han

  • Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions

    Yong Qin;Laurence H. Hurley

  • Making sense of G-quadruplex and i-motif functions in oncogene promoters

    Tracy A. Brooks;Samantha Kendrick;Laurence Hurley

  • Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents

    Daekyu Sun;Kexiao Guo;Jadrian J. Rusche;Laurence H. Hurley

  • Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells.

    E Izbicka;R T Wheelhouse;R T Wheelhouse;E Raymond;K K Davidson

  • The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression.

    Daekyu Sun;Laurence H. Hurley

  • NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA†

    Oleg Yu Fedoroff;Miguel Salazar;Haiyong Han;Violetta V. Chemeris

  • The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo.

    Cory L Grand;Haiyong Han;Rubén M Muñoz;Steve Weitman

  • Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition

    Frank Xiaoguang Han;Richard T. Wheelhouse;Laurence H. Hurley

  • The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4.

    Jeyaprakashnarayanan Seenisamy;Evonne M. Rezler;Tiffanie J. Powell;Denise Tye

  • Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 Promoter

    Thomas S. Dexheimer;Daekyu Sun;Laurence H. Hurley

  • Selective interactions of cationic porphyrins with G-quadruplex structures.

    Haiyong Han;David R. Langley;and Anupama Rangan;Laurence H. Hurley

  • NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region.

    Jixun Dai;Ding Chen;Roger A. C. Jones;Laurence H. Hurley

  • Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure.

    Evonne M. Rezler;Jeyaprakashnarayanan Seenisamy;Sridevi Bashyam;Mu Yong Kim

Frequent Co-Authors

Danzhou Yang
Danzhou Yang Purdue University West Lafayette
David E. Thurston
David E. Thurston King's College London
Heinz G. Floss
Heinz G. Floss University of Washington
Stephen Neidle
Stephen Neidle University College London
Daniel D. Von Hoff
Daniel D. Von Hoff Translational Genomics Research Institute
Michael E. Berens
Michael E. Berens Translational Genomics Research Institute
Nikhil C. Munshi
Nikhil C. Munshi Harvard University
Lisa M. Rimsza
Lisa M. Rimsza Mayo Clinic
Sidney M. Hecht
Sidney M. Hecht Arizona State University
Jeffrey M. Trent
Jeffrey M. Trent Translational Genomics Research Institute

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