Kazuo Shin-ya spends much of his time researching Telomestatin, Stereochemistry, Biochemistry, G-quadruplex and Telomere. His Telomestatin research is multidisciplinary, relying on both Cancer research, Telomeric dna and Analytical chemistry. His Stereochemistry study combines topics from a wide range of disciplines, such as Carboxylic acid, Biosynthesis, Polyketide and Pseudomonas.
His Biochemistry study frequently draws connections to adjacent fields such as Streptomyces. His work deals with themes such as Selectivity, Intramolecular force, Ligand and Circular dichroism, which intersect with G-quadruplex. Kazuo Shin-ya has included themes like Telomere-binding protein, Molecular biology, Telomere Recombination and DNA damage in his Telomere study.
His scientific interests lie mostly in Stereochemistry, Biochemistry, Streptomyces, Microbiology and Telomestatin. The various areas that Kazuo Shin-ya examines in his Stereochemistry study include Derivative and Sponge. His biological study spans a wide range of topics, including Cell culture and Cytotoxicity.
Telomestatin is the topic of his studies on Telomerase, G-quadruplex and Telomere. His study in Telomere is interdisciplinary in nature, drawing from both Molecular biology and Cancer research. As a part of the same scientific family, he mostly works in the field of Biosynthesis, focusing on Gene cluster and, on occasion, Polyketide.
The scientist’s investigation covers issues in Heterologous expression, Gene cluster, Biosynthesis, Gene and Biochemistry. Kazuo Shin-ya has researched Heterologous expression in several fields, including Streptomyces avermitilis, Bacterial artificial chromosome, Polyketide synthase, Cloning and Computational biology. Many of his studies involve connections with topics such as Streptomyces and Gene cluster.
His Streptomyces research incorporates elements of Fermentation, Carbazole, Molecular chaperone GRP78, Stereochemistry and Cytotoxicity. The concepts of his Stereochemistry study are interwoven with issues in Pikromycin, Ring, Biotransformation and Carboxylic acid. The study incorporates disciplines such as Amino acid and Moiety in addition to Biosynthesis.
Kazuo Shin-ya focuses on Heterologous expression, Gene cluster, Biosynthesis, Biochemistry and Gene. The Biosynthesis study combines topics in areas such as Moiety, Stereochemistry, Nucleophilic addition and Aziridine. Many of his studies on Biochemistry apply to Triple helix as well.
His Gene research is multidisciplinary, incorporating perspectives in Streptomyces avermitilis and Streptomyces. His Streptomyces study incorporates themes from Hydrazone and Natural product. Kazuo Shin-ya combines subjects such as Telomestatin and Cell biology with his study of Peptide.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Telomestatin, a Novel Telomerase Inhibitor from Streptomyces anulatus
Kazuo Shin-ya;Konstanty Wierzba;Ken-ichi Matsuo;Toshio Ohtani.
Journal of the American Chemical Society (2001)
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.
Mu Yong Kim;Hariprasad Vankayalapati;Kazuo Shin-Ya;Konstanty Wierzba.
Journal of the American Chemical Society (2002)
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Yuliang Wu;Kazuo Shin-ya;Robert M. Brosh.
Molecular and Cellular Biology (2008)
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.
Jeyaprakashnarayanan Seenisamy;Sridevi Bashyam;Vijay Gokhale;Hariprasad Vankayalapati.
Journal of the American Chemical Society (2005)
Terpene synthases are widely distributed in bacteria
Yuuki Yamada;Tomohisa Kuzuyama;Mamoru Komatsu;Kazuo Shin-ya.
Proceedings of the National Academy of Sciences of the United States of America (2015)
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action
Anne De Cian;Gael Cristofari;Patrick Reichenbach;Elsa De Lemos.
Proceedings of the National Academy of Sciences of the United States of America (2007)
G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells.
H Tahara;K Shin-Ya;H Seimiya;H Yamada.
Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia
T Tauchi;K Shin-ya;G Sashida;M Sumi.
Effect on Tumor Cells of Blocking Survival Response to Glucose Deprivation
Hae-Ryong Park;Akihiro Tomida;Shigeo Sato;Yoshinori Tsukumo.
Journal of the National Cancer Institute (2004)
The G-quadruplex Ligand Telomestatin Inhibits POT1 Binding to Telomeric Sequences In vitro and Induces GFP-POT1 Dissociation from Telomeres in Human Cells
Dennis Gomez;Marie-Françoise O'Donohue;Thomas Wenner;Céline Douarre.
Cancer Research (2006)
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