Kazuo Shin-ya

Overview

Best Publications

• Telomestatin, a Novel Telomerase Inhibitor from Streptomyces anulatus

  Kazuo Shin-ya;Konstanty Wierzba;Ken-ichi Matsuo;Toshio Ohtani

  712
  Citations

• Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.

  Mu Yong Kim;Hariprasad Vankayalapati;Kazuo Shin-Ya;Konstanty Wierzba

  701
  Citations

• Terpene synthases are widely distributed in bacteria

  Yuuki Yamada;Tomohisa Kuzuyama;Mamoru Komatsu;Kazuo Shin-ya

  560
  Citations

• FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.

  Yuliang Wu;Kazuo Shin-ya;Robert M. Brosh

  460
  Citations

• Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.

  Jeyaprakashnarayanan Seenisamy;Sridevi Bashyam;Vijay Gokhale;Hariprasad Vankayalapati

  386
  Citations

• Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action

  Anne De Cian;Gael Cristofari;Patrick Reichenbach;Elsa De Lemos

  342
  Citations

• G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells.

  H Tahara;K Shin-Ya;H Seimiya;H Yamada

  324
  Citations

• Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites

  Mamoru Komatsu;Kyoko Komatsu;Hanae Koiwai;Yuuki Yamada

  285
  Citations

• Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia

  T Tauchi;K Shin-ya;G Sashida;M Sumi

  275
  Citations

• Effect on Tumor Cells of Blocking Survival Response to Glucose Deprivation

  Hae-Ryong Park;Akihiro Tomida;Shigeo Sato;Yoshinori Tsukumo

  259
  Citations

• Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways.

  Tetsuzo Tauchi;Kazuo Shin-Ya;Goro Sashida;Masahiko Sumi

  258
  Citations

• The G-quadruplex Ligand Telomestatin Inhibits POT1 Binding to Telomeric Sequences In vitro and Induces GFP-POT1 Dissociation from Telomeres in Human Cells

  Dennis Gomez;Marie-Françoise O'Donohue;Thomas Wenner;Céline Douarre

  252
  Citations

• Telomestatin-induced Telomere Uncapping Is Modulated by POT1 through G-overhang Extension in HT1080 Human Tumor Cells

  Dennis Gomez;Thomas Wenner;Bertrand Brassart;Céline Douarre

  237
  Citations

• Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters

  Haruo Ikeda;Kazuo Shin-ya;Satoshi Omura

  216
  Citations

• Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands.

  Pravin S. Shirude;Elizabeth R. Gillies;Sylvain Ladame;Frédéric Godde

  199
  Citations

• Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice

  Miki Nishio;Keishi Sugimachi;Hiroki Goto;Jia Wang

  186
  Citations

• Interaction of telomestatin with the telomeric single-strand overhang

  Dennis Gomez;Rajaa Paterski;Thibault Lemarteleur;Kazuo Shin-ya

  178
  Citations

• Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation

  Sakae Saito;Aki Furuno;Junko Sakurai;Asami Sakamoto

  175
  Citations

• Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

  Weiqiang Lin;Shilpa Sampathi;Huifang Dai;Changwei Liu;Changwei Liu

  174
  Citations

• Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp.

  Jin Woo Kim;Hisasi Adachi;Kazuo Shin-Ya;Yoichi Hayakawa

  168
  Citations