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Makoto Nishiyama

Makoto Nishiyama

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
13848
World Ranking
9730
National Ranking
653

Overview

Makoto Nishiyama is affiliated with the University of Tokyo in Japan and has contributed significantly to multiple domains within biochemistry, genetics, and molecular biology. Their work spans across subfields such as molecular biology, pharmacology, surgery, plant science, and organic chemistry.

The main research topics that characterize Nishiyama's scientific contributions include:

  • Microbial Natural Products and Biosynthesis
  • Plant biochemistry and biosynthesis
  • Genomics and Phylogenetic Studies
  • Enzyme Structure and Function
  • Microbial Metabolic Engineering and Bioproduction
  • Carbohydrate Chemistry and Synthesis
  • Spinal Fractures and Fixation Techniques

Nishiyama's publication record is distributed among various prominent scientific journals. Frequent publication venues are:

  • Journal of the American Chemical Society
  • Communications Biology
  • The Journal of General and Applied Microbiology
  • Nature Chemical Biology
  • Cell

Some of their recent papers include:

  • A bacterial sulfoglycosidase highlights mucin O-glycan breakdown in the gut ecosystem, 2023, Nature Chemical Biology
  • Soy and Arabidopsis receptor-like kinases respond to polysaccharide signals from Spodoptera species and mediate herbivore resistance, 2020, Communications Biology
  • A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion, 2022, Cell
  • Reconstitution of a Highly Reducing Type II PKS System Reveals 6π-Electrocyclization Is Required for o-Dialkylbenzene Biosynthesis, 2021, Journal of the American Chemical Society
  • A Natural Dihydropyridazinone Scaffold Generated from a Unique Substrate for a Hydrazine-Forming Enzyme, 2022, Journal of the American Chemical Society

Collaborative work is an important feature of Nishiyama's research. Frequent co-authors include:

  • Saori Kosono
  • Tomohisa Kuzuyama
  • Ayako Yoshida
  • Takeo Tomita
  • Norihiro Isogai

Nishiyama's research contributions integrate knowledge across diverse scientific areas and emphasize enzyme structure and function, microbial metabolism, plant biochemical pathways, and carbohydrate synthesis. Their interdisciplinary approach aligns with developments in molecular biology and biochemistry, supporting various applications ranging from natural product biosynthesis to plant resistance mechanisms.

Best Publications

  • FK228 (Depsipeptide) as a Natural Prodrug That Inhibits Class I Histone Deacetylases

    Ryohei Furumai;Akihisa Matsuyama;Nobuyuki Kobashi;Kun-Hyung Lee

  • A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion.

    Kyonsoo Hong;Lindsay Hinck;Makoto Nishiyama;Mu-ming Poo

  • Calcium stores regulate the polarity and input specificity of synaptic modification.

    Makoto Nishiyama;Kyonsoo Hong;Kyonsoo Hong;Katsuhiko Mikoshiba;Mu-ming Poo

  • Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning.

    Makoto Nishiyama;Akemi Hoshino;Lily Tsai;John R. Henley

  • Calcium signalling in the guidance of nerve growth by netrin-1

    Kyonsoo Hong;Makoto Nishiyama;John Henley;Marc Tessier-Lavigne

  • Histone deacetylase as a new target for cancer chemotherapy.

    Minoru Yoshida;Ryohei Furumai;Makoto Nishiyama;Yasuhiko Komatsu

  • X-ray structure and site-directed mutagenesis of a nitrite reductase from Alcaligenes faecalis S-6: roles of two copper atoms in nitrite reduction.

    Mutsuko Kukimoto;Makoto Nishiyama;Michael E. P. Murphy;Stewart Turley

  • Amidase coupled with low-molecular-mass nitrile hydratase from Rhodococcus rhodochrous J1. Sequencing and expression of the gene and purification and characterization of the gene product.

    Michihiko Kobayashi;Hidenobu Komeda;Toru Nagasawa;Makoto Nishiyama

  • Primary structure of AfsR, a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2)

    Sueharu Horinouchi;Morikazu Kito;Makoto Nishiyama;Kaoru Furuya

  • Determinants of protein thermostability observed in the 1.9-A crystal structure of malate dehydrogenase from the thermophilic bacterium Thermus flavus.

    Clyde A. Kelly;Makoto Nishiyama;Yasuo Ohnishi;Teruhiko Beppu

  • Cloning and characterization of genes responsible for metabolism of nitrile compounds from Pseudomonas chlororaphis B23.

    M Nishiyama;S Horinouchi;M Kobayashi;T Nagasawa

  • Molecular cloning and characterization of a cDNA encoding ent‐cassa‐12,15‐diene synthase, a putative diterpenoid phytoalexin biosynthetic enzyme, from suspension‐cultured rice cells treated with a chitin elicitor

    Eun-Min Cho;Atsushi Okada;Hiromichi Kenmoku;Kazuko Otomo

  • Cloning, nucleotide sequence and expression in Escherichia coli of two cobalt-containing nitrile hydratase genes from Rhodococcus rhodochrous J1.

    Michihiko Kobayashi;Makoto Nishiyama;Toru Nagasawa;Sueharu Horinouchi

  • Taking control over control: use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways.

    Georg Schendzielorz;Martin Dippong;Alexander Grünberger;Dietrich Kohlheyer

  • Catalytic roles for two water bridged residues (Asp-98 and His-255) in the active site of copper-containing nitrite reductase.

    Martin J. Boulanger;Mutsuko Kukimoto;Makoto Nishiyama;Sueharu Horinouchi

  • Primary structure of nitrile hydratase deduced from the nucleotide sequence of a Rhodococcus species and its expression in Escherichia coli

    Osamu Ikehata;Makoto Nishiyama;Sueharu Horinouchi;Teruhiko Beppu

  • A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway : a key to the evolution of amino acid biosynthesis

    Hiromi Nishida;Makoto Nishiyama;Nobuyuki Kobashi;Takehide Kosuge

  • Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities

    Takuto Kumano;Stéphane B. Richard;Joseph P. Noel;Makoto Nishiyama

  • Changes in the Acetylome and Succinylome of Bacillus subtilis in Response to Carbon Source

    Saori Kosono;Masaru Tamura;Shota Suzuki;Yumi Kawamura

  • Cloning and Heterologous Expression of the Cyclooctatin Biosynthetic Gene Cluster Afford a Diterpene Cyclase and Two P450 Hydroxylases

    Seung-Young Kim;Ping Zhao;Masayuki Igarashi;Ryuichi Sawa

Frequent Co-Authors

Tomohisa Kuzuyama
Tomohisa Kuzuyama University of Tokyo
Sueharu Horinouchi
Sueharu Horinouchi University of Tokyo
Teruhiko Beppu
Teruhiko Beppu University of Tokyo
Ko Okumura
Ko Okumura Juntendo University
Hisakazu Yamane
Hisakazu Yamane Teikyo University
Hideoki Ogawa
Hideoki Ogawa Juntendo University
Kazuo Shin-ya
Kazuo Shin-ya National Institute of Advanced Industrial Science and Technology
Minoru Yoshida
Minoru Yoshida University of Tokyo
Shinya Fushinobu
Shinya Fushinobu University of Tokyo
Masaru Tanokura
Masaru Tanokura University of Tokyo

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