World's Best Scientists 2026 revealed!
Tomohisa Kuzuyama

Tomohisa Kuzuyama

D-Index & Metrics

Chemistry

D-Index
60
Citations
13416
World Ranking
9663
National Ranking
691

Biology and Biochemistry

D-Index
60
Citations
13426
World Ranking
11915
National Ranking
817

Overview

Tomohisa Kuzuyama is affiliated with the University of Tokyo in Japan. Their research spans several interconnected fields within biochemistry, genetics, and molecular biology, with a significant focus on molecular biology, pharmacology, and organic chemistry subfields.

Their work covers a range of main topics, including:

  • Microbial Natural Products and Biosynthesis
  • Plant biochemistry and biosynthesis
  • Carbohydrate Chemistry and Synthesis
  • Biochemical and Molecular Research
  • Microbial Metabolic Engineering and Bioproduction
  • Genomics and Phylogenetic Studies
  • Synthetic Organic Chemistry Methods

Kuzuyama has contributed to academic literature through notable recent papers such as:

  • Reconstitution of a Highly Reducing Type II PKS System Reveals 6π-Electrocyclization Is Required for o-Dialkylbenzene Biosynthesis (2021) - Journal of the American Chemical Society
  • A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria (2020) - Nature Chemical Biology
  • Molecular Basis for Enzymatic Aziridine Formation via Sulfate Elimination (2022) - Journal of the American Chemical Society
  • Biosynthetic pathways and enzymes involved in the production of phosphonic acid natural products (2021) - Bioscience Biotechnology and Biochemistry
  • Recent Advances in the Biosynthesis of Carbazoles Produced by Actinomycetes (2020) - Biomolecules

Frequent coauthors in their research include:

  • Makoto Nishiyama
  • Taro Shiraishi
  • R. Nagata
  • Tetsuro Shinada
  • Kazuo Shin-ya

Kuzuyama's publications tend to appear in several recurring journals, which include:

  • Journal of the American Chemical Society
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Angewandte Chemie International Edition
  • The Journal of Antibiotics
  • Biochemistry

The scientist's focus integrates biochemical and molecular research to explore complex biosynthetic pathways and enzyme functions, especially emphasizing microbial natural products and plant biosynthesis. Their work addresses aspects of microbial metabolic engineering and synthetic organic chemistry methods, contributing to understanding the molecular bases of enzymatic processes and natural product formation.

Best Publications

  • Minimum Information about a Biosynthetic Gene cluster.

    Marnix H. Medema;Marnix H. Medema;Renzo Kottmann;Pelin Yilmaz;Matthew Cummings

  • A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis.

    Shunji Takahashi;Tomohisa Kuzuyama;Hiroyuki Watanabe;Haruo Seto

  • Terpene synthases are widely distributed in bacteria

    Yuuki Yamada;Tomohisa Kuzuyama;Mamoru Komatsu;Kazuo Shin-ya

  • Fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis

    Tomohisa Kuzuyama;Tomohiro Shimizu;Shunji Takahashi;Haruo Seto

  • Mevalonate and nonmevalonate pathways for the biosynthesis of isoprene units.

    Tomohisa Kuzuyama

  • Diversity of the biosynthesis of the isoprene units

    Tomohisa Kuzuyama;Haruo Seto

  • Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products

    Tomohisa Kuzuyama;Joseph P. Noel;Stéphane B. Richard

  • Contribution of the Mevalonate and Methylerythritol Phosphate Pathways to the Biosynthesis of Gibberellins inArabidopsis

    Hiroyuki Kasahara;Atsushi Hanada;Tomohisa Kuzuyama;Motoki Takagi

  • Analysis of the Expression of CLA1 , a Gene That Encodes the 1-Deoxyxylulose 5-Phosphate Synthase of the 2- C -Methyl-d-Erythritol-4-Phosphate Pathway in Arabidopsis

    Juan M. Estévez;Araceli Cantero;Cynthia Romero;Hiroshi Kawaide

  • Bioactive natural products with carbon–phosphorus bonds and their biosynthesis

    Haruo Seto;Tomohisa Kuzuyama

  • Direct formation of 2-C-methyl-d-erythritol 4-phosphate from 1-deoxy-d-xylulose 5-phosphate by 1-deoxy-d-xylulose 5-phosphate reductoisomerase, a new enzyme in the non-mevalonate pathway to isopentenyl diphosphate

    Tomohisa Kuzuyama;Shunji Takahashi;Hiroyuki Watanabe;Haruo Seto

  • An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190

    Kazuhide Kaneda;Tomohisa Kuzuyama;Motoki Takagi;Yoichi Hayakawa

  • Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis

    Tomohisa Kuzuyama;Motoki Takagi;Shunji Takahashi;Haruo Seto

  • Formation of 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol from 2-C-methyl-d-erythritol 4-phosphate by 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway

    Tomohisa Kuzuyama;Motoki Takagi;Kazuhide Kaneda;Tohru Dairi

  • The ABBA family of aromatic prenyltransferases: broadening natural product diversity.

    M. Tello;T. Kuzuyama;L. Heide;J. P. Noel

  • Characterization of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase, an Enzyme Involved in Isopentenyl Diphosphate Biosynthesis, and Identification of Its Catalytic Amino Acid Residues

    Tomohisa Kuzuyama;Shunji Takahashi;Motoki Takagi;Haruo Seto

  • Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes

    Ying Ye;Atsushi Minami;Attila Mandi;Chengwei Liu

  • Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol kinase

    Tomohisa Kuzuyama;Motoki Takagi;Kazuhide Kaneda;Hiroyuki Watanabe

  • Elicitor induced activation of the methylerythritol phosphate pathway toward phytoalexins biosynthesis in rice

    Atsushi Okada;Takafumi Shimizu;Kazunori Okada;Tomohisa Kuzuyama

  • Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities

    Takuto Kumano;Stéphane B. Richard;Joseph P. Noel;Makoto Nishiyama

Frequent Co-Authors

Makoto Nishiyama
Makoto Nishiyama University of Tokyo
Haruo Seto
Haruo Seto University of Tokyo
Kazuo Shin-ya
Kazuo Shin-ya National Institute of Advanced Industrial Science and Technology
Tohru Dairi
Tohru Dairi Hokkaido University
Shinya Fushinobu
Shinya Fushinobu University of Tokyo
Kazuo Furihata
Kazuo Furihata University of Tokyo
S.B. Richard
S.B. Richard McGill University
Haruo Ikeda
Haruo Ikeda Kitasato University
Joseph P. Noel
Joseph P. Noel Salk Institute for Biological Studies
Norihiko Misawa
Norihiko Misawa Ishikawa Prefectural University

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